All Studies Meta Analysis

Effect of Moderately High-Dose Vitamin D3 Supplementation on Mortality in Patients Hospitalized for COVID-19 Infection

Sümegi et al., Nutrients, doi:10.3390/nu17030507

Jan 2025

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 125 studies, recognized in 13 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,400+ studies for 118 treatments. c19early.org

Retrospective 148 hospitalized COVID-19 patients showing significantly lower mortality (67% reduction) with moderately high-dose vitamin D3 treatment (30,000 IU for 3 days or 12,000 IU for 7 days followed by 3,000 IU daily), regardless of baseline vitamin D levels. Subgroup analysis of 30 patients showed that treatment resolved deficiencies within 4 days without exceeding normal ranges. The study compared two departments at Semmelweis University, where one department administered vitamin D3 and the other did not. The treatment group had a higher incidence of chronic kidney disease (statistically significant) and was slightly older and had higher severity at baseline (without statistical significance).

This is the 124th of 125 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 66 septillion).

30 studies are RCTs, which show efficacy with p=0.0000032.

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risk of death, 67.3% lower, RR 0.33, p < 0.001, treatment 10 of 76 (13.2%), control 29 of 72 (40.3%), NNT 3.7.

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Sümegi et al., 30 Jan 2025, retrospective, Hungary, peer-reviewed, mean age 67.5, 8 authors, study period December 2022 - April 2023, dosage 30,000IU days 1-3, 3,000IU days 4-28, 30,000IU for 3 days or 12,000IU for 7 days, followed by 3,000IU daily. Contact: takacs.istvan@semmelweis.hu.

This Paper Vitamin D All

Effect of Moderately High-Dose Vitamin D3 Supplementation on Mortality in Patients Hospitalized for COVID-19 Infection

Liza Dalma Sümegi, Marina Varga, Veronika Kadocsa, Balázs Szili, Márk Stempler, Péter András Lakatos, Zsuzsanna Németh, István Takács

Nutrients, doi:10.3390/nu17030507

Background: Despite a large number of published studies, the effect of vitamin D3 supplementation on mortality in hospitalized patients, as well as the recommended dose and duration of therapy, is unclear. In our retrospective study, we aimed to investigate the impact of vitamin D deficiency and moderately high-dose vitamin D3 supplementation on mortality and disease outcomes in patients with COVID-19 infection. Methods: We analyzed data from 148 COVID-19-infected hospitalized patients in two different departments, Internal Medicine and Oncology, at Semmelweis University. The severity of COVID-19 and the treatment used were the same except at one of the departments, where patients received circa 90,000 IU of vitamin D3. We compared in-hospital mortality rates between the groups. In a subgroup analysis, we evaluated the efficacy and safety of vitamin D3 supplementation by assessing 25(OH)D and 1,25(OH) 2 D concentrations on days 0, 4, and 8. Results: As a result of the supplementation, the deficiency was resolved in 4 days in deficient patients, and none of the 25(OH)D or 1,25(OH) 2 D concentrations exceeded the normal range. Mortality was significantly lower and decreased 67% in the group receiving vitamin D3 supplementation, regardless of baseline 25(OH)D concentrations. Conclusions: The supplemental dosage, 3 × 30,000 IU of vitamin D3, is effective and safe and may reduce mortality in COVID-19 infection.

Author Contributions: L.D.S.: idea, design, data collection and processing, visualization, and paper writing; M.V.: clinical sample processing; V.K.: data collection; B.S.: data collection; M.S.: data collection; P.A.L.: idea and design; Z.N.: idea, design, statistical analysis, visualization, and paper review; I.T.: idea, design, resources, paper writing, paper review, and final approval. All authors have read and agreed to the published version of the manuscript. Appendix A List A1. Definitions of Chronic Diseases The chronic diseases were defined based on the following variables:

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Late treatment
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