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0 0.5 1 1.5 2+ Severe case 97% Improvement Relative Risk c19early.org/r Kneidinger et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study
Kneidinger et al., Infection, doi:10.1007/s15010-022-01914-8
9 Sep 2022    Source   PDF   Share   Tweet
Retrospective 218 COVID+ lung transplant patients in Germany, showing no significant difference in severe cases with early casirivimab/imdevimab use.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of severe case, 97.2% lower, RR 0.03, p = 0.45, treatment 0 of 3 (0.0%), control 34 of 215 (15.8%), NNT 6.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kneidinger et al., 9 Sep 2022, retrospective, Germany, peer-reviewed, 11 authors, study period 1 January, 2022 - 20 March, 2022, lung transplant patients.
Contact: nikolaus.kneidinger@med.uni-muenchen.de.
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