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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Severe case -20% Improvement Relative Risk c19early.org/v Kneidinger et al. Sotrovimab for COVID-19 EARLY Favors sotrovimab Favors control
Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study
Kneidinger et al., Infection, doi:10.1007/s15010-022-01914-8
9 Sep 2022    Source   PDF   Share   Tweet
Retrospective 218 COVID+ lung transplant patients in Germany, showing no significant difference in severe cases with early sotrovimab use.
Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.1 [Liu, Sheward, VanBlargan] and a lack of efficacy for BA.2 [Zhou]. US EUA has been revoked.
risk of severe case, 20.2% higher, RR 1.20, p = 0.79, treatment 21 of 125 (16.8%), control 13 of 93 (14.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kneidinger et al., 9 Sep 2022, retrospective, Germany, peer-reviewed, 11 authors, study period 1 January, 2022 - 20 March, 2022, lung transplant patients.
Contact: nikolaus.kneidinger@med.uni-muenchen.de.
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