Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study

{ 'indexed': {'date-parts': [[2022, 9, 9]], 'date-time': '2022-09-09T13:14:24Z', 'timestamp': 1662729264827}, 'reference-count': 29, 'publisher': 'Springer Science and Business Media LLC', 'license': [ { 'start': { 'date-parts': [[2022, 9, 9]], 'date-time': '2022-09-09T00:00:00Z', 'timestamp': 1662681600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 9, 9]], 'date-time': '2022-09-09T00:00:00Z', 'timestamp': 1662681600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [{'name': 'Universitätsklinik München'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Purpose</jats:title>\n' ' <jats:p>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory ' 'syndrome coronavirus type 2 (SARS-CoV-2) is currently the major threat for immunocompromised ' 'individuals. The course of COVID-19 in lung transplant recipients in the Omicron era remains ' 'unknown. The aim of the study was to assess outcome and associated factors in lung transplant ' 'recipients in a German-wide multicenter approach.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>All affected individuals from January 1st to March 20th, 2022 from 8 ' 'German centers during the Omicron wave were collected. Baseline characteristics and antiviral ' 'measures were associated with outcome.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Of 218 patients with PCR-proven SARS-CoV-2 infection 166 patients (76%) ' 'received any early (&lt;\u20097\xa0days) antiviral therapy median 2 (interquartile range 1–4) ' 'days after symptom onset. Most patients received sotrovimab (57%), followed by remdesivir ' '(21%) and molnupiravir (21%). An early combination therapy was applied in 45 patients (21%). ' 'Thirty-four patients (16%) developed a severe or critical disease severity according to the ' 'WHO scale. In total, 14 patients (6.4%) died subsequently associated with COVID-19. Neither ' 'vaccination and antibody status, nor applied treatments were associated with outcome. Only ' 'age and glomerular filtration rate\u2009&lt;\u200930\xa0ml/min/1.73m<jats:sup>2</jats:sup> ' 'were independent risk factors for a severe or critical COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>COVID-19 due to Omicron remains an important threat for lung transplant ' 'recipients. In particular, elderly patients and patients with impaired kidney function are at ' 'risk for worse outcome. Prophylaxis and therapy in highly immunocompromised individuals need ' 'further improvement.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1007/s15010-022-01914-8', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 9]], 'date-time': '2022-09-09T12:37:36Z', 'timestamp': 1662727056000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide ' 'German study', 'prefix': '10.1007', 'author': [ {'given': 'Nikolaus', 'family': 'Kneidinger', 'sequence': 'first', 'affiliation': []}, {'given': 'Matthias', 'family': 'Hecker', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vasiliki', 'family': 'Bessa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ina', 'family': 'Hettich', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandra', 'family': 'Wald', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sabine', 'family': 'Wege', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna-Barbara', 'family': 'Nolde', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maike', 'family': 'Oldigs', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zulfiya', 'family': 'Syunyaeva', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heinrike', 'family': 'Wilkens', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jens', 'family': 'Gottlieb', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 9, 9]]}, 'reference': [ { 'key': '1914_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1825', 'DOI': '10.1111/ajt.16369', 'volume': '21', 'author': 'E Coll', 'year': '2021', 'unstructured': 'Coll E, Fernández-Ruiz M, Sánchez-Álvarez JE, et al. 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