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All Studies   Meta Analysis    Recent:   

Vitamin D supplementation is beneficial in improving the prognosis of patients with acute respiratory failure in the intensive care unit: a retrospective study based on the MIMIC-IV database

Hu et al., Frontiers in Medicine, doi:10.3389/fmed.2023.1271060
Nov 2023  
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Mortality, in hospital 40% Improvement Relative Risk Mortality, ICU 46% Vitamin D for ARF  Hu et al.  ICU PATIENTS Is very late treatment with vitamin D beneficial for ARF? PSM retrospective 7,994 patients in the USA Lower mortality with vitamin D (p<0.000001) c19early.org Hu et al., Frontiers in Medicine, November 2023 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 7,994 ICU patients with acute respiratory failure (not COVID-19 specific) in the USA showing significantly lower mortality with vitamin D supplementation.
risk of death, 40.1% lower, HR 0.60, p < 0.001, treatment 1,053, control 1,053, adjusted per study, inverted to make HR<1 favor treatment, in hospital, propensity score matching, multivariable, Cox proportional hazards, model 3.
risk of death, 45.9% lower, HR 0.54, p < 0.001, treatment 1,053, control 1,053, adjusted per study, inverted to make HR<1 favor treatment, ICU, propensity score matching, multivariable, Cox proportional hazards, model 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hu et al., 23 Nov 2023, retrospective, USA, peer-reviewed, 6 authors. Contact: zeyou06@163.com.
This PaperVitamin DAll
Vitamin D supplementation is beneficial in improving the prognosis of patients with acute respiratory failure in the intensive care unit: a retrospective study based on the MIMIC-IV database
Song Hu, Qian He, Jun Xie, Hui Liu, Rong Zhou, Chong Li
Frontiers in Medicine, doi:10.3389/fmed.2023.1271060
Background: Vitamin D plays a critical role in the regulation of multiple physiological pathways. Vitamin D deficiency may be a risk factor for lifethreatening clinical conditions. Several studies have found that vitamin D supplementation in critically ill patients improves prognosis. The purpose of this study was to determine the association between vitamin D and the prognosis of patients with acute respiratory failure (ARF). Methods: In this retrospective cohort study, we collected clinical information of ARF patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.0 database. The outcome of this study was in-hospital mortality, intensive care unit (ICU) mortality. Patients were divided into the no-vitamin D and vitamin D groups according to whether they received supplementation or not. The correlation between vitamin D and outcome was examined using Kaplan-Meier (KM) survival curves, Cox proportional risk regression models and subgroup analyses. Propensity-score matching (PSM) was used to ensure the robustness of our findings. Results: The study finally included 7,994 patients with ARF, comprising 6,926 and 1,068 in the no-vitamin D and vitamin D groups, respectively. The Kaplan-Meier survival curve indicated a significant difference in survival probability between the two groups. After adjustment for a series of confounders, the multivariate Cox proportional hazards models showed that the hazard ratio (95% confidence interval) values for in-hospital and ICU mortality in the no-vitamin D group were 1.67 (1.45, 1.93) and 1.64 (1.36, 1.98), respectively. The results of propensity score-matched (PSM) analysis were consistent with the original population. In the subgroup analysis, Vitamin D supplementation was associated with lower in-hospital mortality in patients with higher clinical scores (SOFA score ≥ 8, OASIS ≥ 38). Conclusion: Our study concluded that Vitamin D supplementation may reduce in-hospital and ICU mortality in patients with ARF in the ICU. There may be a beneficial effect on in-hospital mortality in patients with higher clinical scores. Additional randomized controlled trials are needed to follow up to confirm the relationship between vitamin D supplementation and ARF.
Ethics statement The studies involving humans were approved by Institutional Review Board of the Massachusetts Institute of Technology and Beth Israel Deaconess Medical Center. Written informed consent for participation was not required for this study in accordance with the National Legislation and the Institutional requirements. Author contributions Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2023.1271060/ full#supplementary-material
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The purpose of this study was ' 'to determine the association between vitamin D and the prognosis of patients with acute ' 'respiratory failure ' '(ARF).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this ' 'retrospective cohort study, we collected clinical information of ARF patients from the ' 'Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.0 database. The outcome ' 'of this study was in-hospital mortality, intensive care unit (ICU) mortality. Patients were ' 'divided into the no-vitamin D and vitamin D groups according to whether they received ' 'supplementation or not. The correlation between vitamin D and outcome was examined using ' 'Kaplan–Meier (KM) survival curves, Cox proportional risk regression models and subgroup ' 'analyses. Propensity-score matching (PSM) was used to ensure the robustness of our ' 'findings.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The study ' 'finally included 7,994 patients with ARF, comprising 6,926 and 1,068 in the no-vitamin D and ' 'vitamin D groups, respectively. The Kaplan–Meier survival curve indicated a significant ' 'difference in survival probability between the two groups. After adjustment for a series of ' 'confounders, the multivariate Cox proportional hazards models showed that the hazard ratio ' '(95% confidence interval) values for in-hospital and ICU mortality in the no-vitamin D group ' 'were 1.67 (1.45, 1.93) and 1.64 (1.36, 1.98), respectively. The results of propensity ' 'score-matched (PSM) analysis were consistent with the original population. 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'Covit-trial study group. High-dose versus standard-dose Vitamin D ' 'supplementation in older adults with Covid-19 (Covit-trial): a ' 'multicenter, open-label, randomized controlled superiority trial', 'volume': '19', 'author': 'Annweiler', 'year': '2022', 'journal-title': 'PLoS Med'}, { 'key': 'ref33', 'doi-asserted-by': 'publisher', 'first-page': '1234', 'DOI': '10.3390/Nu15051234', 'article-title': 'Vitamin D supplementation and clinical outcomes in severe Covid-19 ' 'patients-randomized controlled trial', 'volume': '15', 'author': 'Domazet Bugarin', 'year': '2023', 'journal-title': 'Nutrients'}, { 'key': 'ref34', 'doi-asserted-by': 'publisher', 'first-page': '765', 'DOI': '10.1007/S40618-020-01370-X', 'article-title': 'Vitamin D deficiency as a predictor of poor prognosis in patients with ' 'acute respiratory failure due to Covid-19', 'volume': '44', 'author': 'GE', 'year': '2021', 'journal-title': 'J Endocrinol Investig'}, { 'key': 'ref35', 'doi-asserted-by': 'publisher', 'first-page': '1754', 'DOI': '10.1001/Jama.286.14.1754', 'article-title': 'Serial evaluation of the SOFA score to predict outcome in critically ' 'ill patients', 'volume': '286', 'author': 'Ferreira', 'year': '2001', 'journal-title': 'JAMA'}, { 'key': 'ref36', 'doi-asserted-by': 'publisher', 'first-page': 'E7083', 'DOI': '10.7717/Peerj.7083', 'article-title': 'Prognosis predictive value of the Oxford acute severity of illness ' 'score for Sepsis: a retrospective cohort study', 'volume': '7', 'author': 'Chen', 'year': '2019', 'journal-title': 'Peerj'}, { 'key': 'ref37', 'doi-asserted-by': 'publisher', 'first-page': '76', 'DOI': '10.1186/S12931-021-01666-3', 'article-title': 'Circulating Vitamin D levels status and clinical prognostic indices in ' 'Covid-19 patients', 'volume': '22', 'author': 'Ricci', 'year': '2021', 'journal-title': 'Respir Res'}], 'container-title': 'Frontiers in Medicine', 'original-title': [], 'link': [ { 'URL': 'https://www.frontiersin.org/articles/10.3389/fmed.2023.1271060/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 11, 23]], 'date-time': '2023-11-23T11:52:41Z', 'timestamp': 1700740361000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.frontiersin.org/articles/10.3389/fmed.2023.1271060/full'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 11, 23]]}, 'references-count': 37, 'alternative-id': ['10.3389/fmed.2023.1271060'], 'URL': 'http://dx.doi.org/10.3389/fmed.2023.1271060', 'relation': {}, 'ISSN': ['2296-858X'], 'subject': ['General Medicine'], 'container-title-short': 'Front. Med.', 'published': {'date-parts': [[2023, 11, 23]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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