Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial

{ 'indexed': {'date-parts': [[2022, 7, 4]], 'date-time': '2022-07-04T06:12:57Z', 'timestamp': 1656915177430}, 'reference-count': 60, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2022, 7, 4]], 'date-time': '2022-07-04T00:00:00Z', 'timestamp': 1656892800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'abstract': '<jats:p>There is now sufficient evidence to support that vitamin D deficiency may predispose ' 'to SARS-CoV-2 infection and increase COVID-19 severity and mortality. It has been suggested ' 'that vitamin D<jats:sub>3</jats:sub> supplementation may be used prophylactically as an ' 'affordable and safe strategy that could be added to the existing COVID-19 standard treatment. ' 'This multicenter, single-blinded, prospective randomized pilot clinical trial aimed to ' 'evaluate the safety, tolerability, and effectiveness of 10,000 IU/day in comparison with 2000 ' 'IU/day of cholecalciferol supplementation for 14\xa0days to reduce the duration and severity ' 'of COVID-19 in 85 hospitalized individuals. The median age of the participants was 65\xa0' 'years (Interquartile range (IQR): 53–74), most of them (71%) were men and the mean baseline ' 'of 25-hydroxyvitamin D (25(OH)D) in serum was 15\xa0ng/ml (standard deviation (SD):6). After ' '14\xa0days of supplementation, serum 25(OH)D levels were significantly increased in the group ' 'who received 10,000IU/day (<jats:italic>p</jats:italic> &amp;lt; 0.0001) ' '(<jats:italic>n</jats:italic> = 44) in comparison with the 2,000IU/day group ' '(<jats:italic>n</jats:italic> = 41), especially in overweight and obese participants, and the ' 'higher dose was well tolerated. A fraction of the individuals in our cohort (10/85) developed ' 'acute respiratory distress syndrome (ARDS). The median length of hospital stay in these ' 'patients with ARDS was significantly different in the participants assigned to the ' '10,000IU/day group (<jats:italic>n</jats:italic> = 4; 7 days; IQR: 4–13) and the 2,000IU/day ' 'group (<jats:italic>n</jats:italic> = 6; 27 days; IQR: 12–45) (<jats:italic>p</jats:italic> = ' '0.04). Moreover, the inspired oxygen fraction was reduced 7.6-fold in the high dose group ' '(<jats:italic>p</jats:italic> = 0.049). In terms of blood parameters, we did not identify ' 'overall significant improvements, although the platelet count showed a modest but significant ' 'difference in those patients who were supplemented with the higher dose ' '(<jats:italic>p</jats:italic> = 0.0492). In conclusion, the administration of 10,000IU/day of ' 'vitamin D<jats:sub>3</jats:sub> for 14\xa0days in association with the standard clinical care ' 'during hospitalization for COVID-19 was safe, tolerable, and beneficial, thereby helping to ' 'improve the prognosis during the recovery process.</jats:p>', 'DOI': '10.3389/fphar.2022.863587', 'type': 'journal-article', 'created': {'date-parts': [[2022, 7, 4]], 'date-time': '2022-07-04T05:57:15Z', 'timestamp': 1656914235000}, 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized ' 'Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical ' 'Trial', 'prefix': '10.3389', 'volume': '13', 'author': [ {'given': 'Miguel', 'family': 'Cervero', 'sequence': 'first', 'affiliation': []}, {'given': 'Daniel', 'family': 'López-Wolf', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guiomar', 'family': 'Casado', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria', 'family': 'Novella-Mena', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pablo', 'family': 'Ryan-Murua', 'sequence': 'additional', 'affiliation': []}, { 'given': 'María Luisa', 'family': 'Taboada-Martínez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara', 'family': 'Rodríguez-Mora', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorena', 'family': 'Vigón', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mayte', 'family': 'Coiras', 'sequence': 'additional', 'affiliation': []}, {'given': 'Montserrat', 'family': 'Torres', 'sequence': 'additional', 'affiliation': []}], 'member': '1965', 'published-online': {'date-parts': [[2022, 7, 4]]}, 'reference': [ { 'key': 'B1', 'doi-asserted-by': 'publisher', 'first-page': '333', 'DOI': '10.1016/j.amjms.2021.06.005', 'article-title': 'Low Serum Levels of 25-Hydroxyvitamin D Accompany Severe COVID-19 ' 'Because it Is a Negative Acute Phase Reactant', 'volume': '362', 'author': 'Antonelli', 'year': '2021', 'journal-title': 'Am. 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