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0 0.5 1 1.5 2+ Mortality -7% Improvement Relative Risk ICU admission 79% ARDS 28% Cervero et al. Vitamin D for COVID-19 RCT LATE TREATMENT Is late treatment with vitamin D beneficial for COVID-19? RCT 85 patients in Spain (June 2020 - March 2021) Lower ICU admission with vitamin D (not stat. sig., p=0.2) Cervero et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.863587 Favors high dose Favors low dose
Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial
Cervero et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.863587
Cervero et al., Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With.., Frontiers in Pharmacology, doi:10.3389/fphar.2022.863587
Jul 2022   Source   PDF  
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RCT 85 hospitalized patients in Spain, comparing 10,000IU/day vs. 2,000IU/day cholecalciferol, showing beneficial effects of the larger dose.
risk of death, 7.3% higher, RR 1.07, p = 1.00, treatment 1 of 41 (2.4%), control 1 of 44 (2.3%).
risk of ICU admission, 78.5% lower, RR 0.21, p = 0.20, treatment 1 of 41 (2.4%), control 5 of 44 (11.4%), NNT 11.
risk of ARDS, 28.5% lower, RR 0.72, p = 0.74, treatment 4 of 41 (9.8%), control 6 of 44 (13.6%), NNT 26.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cervero et al., 4 Jul 2022, Single Blind Randomized Controlled Trial, placebo-controlled, Spain, peer-reviewed, median age 65.0, 10 authors, study period June 2020 - March 2021, average treatment delay 7.0 days, dosage 10,000IU days 1-14.
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This PaperVitamin DAll
Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial
Miguel Cervero, Daniel López-Wolf, Guiomar Casado, Maria Novella-Mena, Pablo Ryan-Murua, María Luisa Taboada-Martínez, Sara Rodríguez-Mora, Lorena Vigón, Mayte Coiras, Montserrat Torres
Frontiers in Pharmacology, doi:10.3389/fphar.2022.863587
There is now sufficient evidence to support that vitamin D deficiency may predispose to SARS-CoV-2 infection and increase COVID-19 severity and mortality. It has been suggested that vitamin D 3 supplementation may be used prophylactically as an affordable and safe strategy that could be added to the existing COVID-19 standard treatment. This multicenter, single-blinded, prospective randomized pilot clinical trial aimed to evaluate the safety, tolerability, and effectiveness of 10,000 IU/day in comparison with 2000 IU/day of cholecalciferol supplementation for 14 days to reduce the duration and severity of COVID-19 in 85 hospitalized individuals. The median age of the participants was 65 years (Interquartile range (IQR): 53-74), most of them (71%) were men and the mean baseline of 25-hydroxyvitamin D (25(OH)D) in serum was 15 ng/ml (standard deviation (SD):6). After 14 days of supplementation, serum 25(OH)D levels were significantly increased in the group who received 10,000IU/day (p < 0.0001) (n = 44) in comparison with the 2,000IU/day group (n = 41), especially in overweight and obese participants, and the higher dose was well tolerated. A fraction of the individuals in our cohort (10/85) developed acute respiratory distress syndrome (ARDS). The median length of hospital stay in these patients with ARDS was significantly different in the participants assigned to the 10,000IU/day group (n = 4; 7 days; IQR: 4-13) and the 2,000IU/day group (n = 6; 27 days; IQR: 12-45) (p = 0.04). Moreover, the inspired oxygen fraction was reduced 7.6-fold in the high dose group (p = 0.049). In terms of blood parameters, we did not identify overall significant improvements, although the platelet count showed a modest but significant difference in those patients who were supplemented with the higher dose (p = 0.0492). In conclusion, the administration of 10,000IU/day of vitamin D 3 for 14 days in
Adverse Events Treatment Group 2000 UI/day (n = 44) 10,000 UI/day (n = 41) Cytolysis-no. (%) 1 (2%) Diarrhea-no. (%) 1 (2%) Pulmonary embolism-no. (%) 2 (5%) 1 (2%) Neuropathy-no. (%) 1 (2%) Urinary (tract) infection-no. (%) 2 (5%) ETHICS STATEMENT SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: full#supplementary-material Conflict of Interest: Drug Cholecalciferol (vitamin D) used in this study was donated by Italfarmaco Group (Cholecalciferol 25,000IU/2.5 ml oral solution). Italfarmaco Group had no role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or the preparation, review, or approval of the manuscript. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Iqr, Sd, No, There were no differences between treatment groups
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Late treatment
is less effective
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