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Home   COVID-19 treatment studies for Vitamin D  COVID-19 treatment studies for Vitamin D  C19 studies: Vitamin D  Vitamin D   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 40% Improvement Relative Risk Ventilation 60% ICU admission 40% ICU time 36% Hospitalization time 17% c19early.org/d Maghbooli et al. Vitamin D for COVID-19 RCT LATE Favors vitamin D Favors control
Treatment with 25-hydroxyvitamin D3 (calcifediol) is associated with a reduction in the blood neutrophil-to-lymphocyte ratio marker of disease severity in patients hospitalized with COVID-19: a pilot, multicenter, randomized, placebo-controlled double blind clinical trial
Maghbooli et al., Endocrine Practice, doi:10.1016/j.eprac.2021.09.016
13 Oct 2021    Source   PDF   Share   Tweet
RCT 106 hospitalized patients with vitamin D levels <30ng/ml in Iran, 53 treated with calcifediol, showing that treatment was able to correct vitamin D deficiency/insufficiency, resulting in improved immune system function. Hospitalization, ICU duration, ventilation, and mortality was lower with treatment, without reaching statistical significance with the small sample size. The dosage used in this trial was much lower than other trials.
Although the 40% lower mortality is not statistically significant, it is consistent with the significant 37% lower mortality [28‑44%] from meta analysis of the 59 mortality results to date.
risk of death, 40.0% lower, RR 0.60, p = 0.72, treatment 3 of 53 (5.7%), control 5 of 53 (9.4%), NNT 26.
risk of mechanical ventilation, 60.0% lower, RR 0.40, p = 0.44, treatment 2 of 53 (3.8%), control 5 of 53 (9.4%), NNT 18.
risk of ICU admission, 40.0% lower, RR 0.60, p = 0.42, treatment 6 of 53 (11.3%), control 10 of 53 (18.9%), NNT 13.
ICU time, 36.4% lower, relative time 0.64, p = 0.20, treatment 53, control 53.
hospitalization time, 16.7% lower, relative time 0.83, p = 0.10, treatment 53, control 53.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Maghbooli et al., 13 Oct 2021, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 12 authors, dosage calcifediol 25μg daily, mean daily dose.
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This PaperVitamin DAll
Late treatment
is less effective
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