Treatment with 25-hydroxyvitamin D3 (calcifediol) is associated with a reduction in the blood neutrophil-to-lymphocyte ratio marker of disease severity in patients hospitalized with COVID-19: a pilot, multicenter, randomized, placebo-controlled double blind clinical trial

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"Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis", "author": "Lippi", "doi-asserted-by": "crossref", "first-page": "190", "journal-title": "Clin Chim Acta", "key": "10.1016/j.eprac.2021.09.016_bib2", "volume": "505", "year": "2020" }, { "DOI": "10.1183/13993003.00547-2020", "article-title": "Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis", "author": "Guan", "doi-asserted-by": "crossref", "first-page": "2000547", "issue": "5", "journal-title": "Eur Respir", "key": "10.1016/j.eprac.2021.09.016_bib3", "volume": "55", "year": "2020" }, { "DOI": "10.1136/bmj.i6583", "article-title": "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data", "author": "Martineau", "doi-asserted-by": "crossref", "first-page": "i6583", "journal-title": "BMJ", "key": "10.1016/j.eprac.2021.09.016_bib4", "volume": "356", "year": "2017" }, { "DOI": "10.1371/journal.pone.0239799", "article-title": "Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection", "author": "Maghbooli", "doi-asserted-by": "crossref", "issue": "9", "journal-title": "PloS One", "key": "10.1016/j.eprac.2021.09.016_bib5", "volume": "15", "year": "2020" }, { "DOI": "10.1371/journal.pone.0239252", "article-title": "SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels", "author": "Kaufman", "doi-asserted-by": "crossref", "issue": "9", "journal-title": "PloS One", "key": "10.1016/j.eprac.2021.09.016_bib6", "volume": "15", "year": "2020" }, { "article-title": "Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis", "author": "Pereira", "first-page": "1", "journal-title": "Crit Rev Food Sci Nutr", "key": "10.1016/j.eprac.2021.09.016_bib7", "year": "2020" }, { "DOI": "10.1001/jama.2020.26848", "article-title": 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"10.1016/j.eprac.2021.09.016_bib15", "volume": "98", "year": "2013" }, { "DOI": "10.1002/jbmr.551", "article-title": "Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity", "author": "Bischoff-Ferrari", "doi-asserted-by": "crossref", "first-page": "160", "issue": "1", "journal-title": "J Bone Miner Res", "key": "10.1016/j.eprac.2021.09.016_bib16", "volume": "27", "year": "2012" }, { "DOI": "10.3390/nu11051016", "article-title": "Hypovitaminosis D: is it time to consider the use of calcifediol?", "author": "Cesareo", "doi-asserted-by": "crossref", "first-page": "1016", "issue": "5", "journal-title": "Nutrients", "key": "10.1016/j.eprac.2021.09.016_bib17", "volume": "11", "year": "2019" }, { "DOI": "10.1210/er.2018-00126", "article-title": "Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions", "author": "Bouillon", "doi-asserted-by": "crossref", "first-page": "1109", "issue": "4", "journal-title": "Endocr Rev", "key": "10.1016/j.eprac.2021.09.016_bib18", "volume": "40", "year": "2019" }, { "DOI": "10.1016/j.mayocp.2013.05.011", "article-title": "Vitamin D for health: a global perspective", "author": "Hossein-Nezhad", "doi-asserted-by": "crossref", "first-page": "720", "issue": "7", "journal-title": "Mayo Clin Proc", "key": "10.1016/j.eprac.2021.09.016_bib19", "volume": "88", "year": "2013" }, { "DOI": "10.1186/s12883-021-02200-0", "article-title": "Reduction in circulating vitamin D binding protein in patients with multiple sclerosis", "author": "Maghbooli", "doi-asserted-by": "crossref", "first-page": "168", "issue": "1", "journal-title": "BMC Neurol", "key": "10.1016/j.eprac.2021.09.016_bib20", "volume": "21", "year": "2021" }, { "DOI": "10.3390/nu12072097", "article-title": "Immunologic effects of vitamin D on human health and disease", "author": "Charoenngam", "doi-asserted-by": "crossref", "first-page": "2097", "issue": "7", "journal-title": "Nutrients", "key": "10.1016/j.eprac.2021.09.016_bib21", "volume": "12", "year": "2020" }, { "DOI": "10.3390/nu12061617", "article-title": "Cholecalciferol or calcifediol in the management of vitamin D deficiency", "author": "Sosa Henríquez", "doi-asserted-by": "crossref", "first-page": "1617", "issue": "6", "journal-title": "Nutrients", "key": "10.1016/j.eprac.2021.09.016_bib22", "volume": "12", "year": "2020" }, { "DOI": "10.1016/j.jsbmb.2016.01.014", "article-title": "Vitamin D3 and calcidiol are not equipotent", "author": "Navarro-Valverde", "doi-asserted-by": "crossref", "first-page": "205", "journal-title": "J Steroid Biochem Mol Biol", "key": "10.1016/j.eprac.2021.09.016_bib23", "volume": "164", "year": "2016" }, { "DOI": "10.1007/s001980050058", "article-title": "Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men", "author": "Barger-Lux", "doi-asserted-by": "crossref", "first-page": "222", "issue": "3", "journal-title": "Osteoporos Int", "key": "10.1016/j.eprac.2021.09.016_bib24", "volume": "8", "year": "1998" }, { "DOI": "10.1093/ajcn/nqab123", "article-title": "A pilot-randomized, double-blind crossover trial to evaluate the pharmacokinetics of orally administered 25-hydroxyvitamin D3 and vitamin D3 in healthy adults with differing BMI and in adults with intestinal malabsorption", "author": "Charoenngam", "doi-asserted-by": "crossref", "first-page": "1189", "issue": "3", "journal-title": "Am J Clin Nutr", "key": "10.1016/j.eprac.2021.09.016_bib25", "volume": "114", "year": "2021" }, { "DOI": "10.1016/j.ecl.2010.02.010", "article-title": "Vitamin D and the immune system: new perspectives on an old theme", "author": "Hewison", "doi-asserted-by": "crossref", "first-page": "365", "issue": "2", "journal-title": "Endocrinol Metab Clin North Am", "key": "10.1016/j.eprac.2021.09.016_bib26", "volume": "39", "year": "2010" }, { "DOI": "10.1136/jcp.s3-13.1.39", "article-title": "Lymphocyte function and virus infections", "author": "Denman", "doi-asserted-by": "crossref", "first-page": "39", "journal-title": "J Clin Pathol Suppl (R Coll Pathol)", "key": "10.1016/j.eprac.2021.09.016_bib27", "volume": "13", "year": "1979" }, { "DOI": "10.1002/cyto.a.24172", "article-title": "Lymphocyte subset counts in COVID-19 patients: a meta-analysis", "author": "Huang", "doi-asserted-by": "crossref", "first-page": "772", "issue": "8", "journal-title": "Cytometry A", "key": "10.1016/j.eprac.2021.09.016_bib28", "volume": "97", "year": "2020" }, { "DOI": "10.1155/2020/8829674", "article-title": "COVID-19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps", "author": "Borges", "doi-asserted-by": "crossref", "first-page": "8829674", "journal-title": "Mediators Inflamm", "key": "10.1016/j.eprac.2021.09.016_bib29", "volume": "2020", "year": "2020" }, { "DOI": "10.1002/jmv.25819", "article-title": "Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis", "author": "Lagunas-Rangel", "doi-asserted-by": "crossref", "first-page": "1733", "issue": "10", "journal-title": "J Med Virol", "key": "10.1016/j.eprac.2021.09.016_bib30", "volume": "92", "year": "2020" }, { "DOI": "10.3390/nu13061760", "article-title": "Calcifediol treatment and hospital mortality due to COVID-19: a cohort study", "author": "Alcala-Diaz", "doi-asserted-by": "crossref", "first-page": "1760", "issue": "6", "journal-title": "Nutrients", "key": "10.1016/j.eprac.2021.09.016_bib31", "volume": "13", "year": "2021" }, { "DOI": "10.1210/clinem/dgab405", "article-title": "Calcifediol treatment and COVID-19-related outcomes", "author": "Nogues", "doi-asserted-by": "crossref", "first-page": "e4017", "issue": "10", "journal-title": "J Clin Endocrinol Metab", "key": "10.1016/j.eprac.2021.09.016_bib32", "volume": "106", "year": "2021" }, { "DOI": "10.1016/j.jsbmb.2020.105771", "article-title": "Vitamin D and survival in COVID-19 patients: a quasi-experimental study", "author": "Annweiler", "doi-asserted-by": "crossref", "first-page": "105771", "journal-title": "J Steroid Biochem Mol Biol", "key": "10.1016/j.eprac.2021.09.016_bib33", "volume": "204", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30211-7", "article-title": "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study", "author": "Chen", "doi-asserted-by": "crossref", "first-page": "507", "issue": "10223", "journal-title": "Lancet", "key": "10.1016/j.eprac.2021.09.016_bib34", "volume": "395", "year": "2020" }, { "DOI": "10.1001/jama.2020.2648", "article-title": "Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention", "author": "Wu", "doi-asserted-by": "crossref", "first-page": "1239", "issue": "13", "journal-title": "JAMA", "key": "10.1016/j.eprac.2021.09.016_bib35", "volume": "323", "year": "2020" }, { "DOI": "10.1016/S2213-2600(20)30076-X", "article-title": "Pathological findings of COVID-19 associated with acute respiratory distress syndrome", "author": "Xu", "doi-asserted-by": "crossref", "first-page": "420", "issue": "4", "journal-title": "Lancet Respir Med", "key": "10.1016/j.eprac.2021.09.016_bib36", "volume": "8", "year": "2020" }, { "DOI": "10.1016/j.jsbmb.2018.12.010", "article-title": "Daily oral dosing of vitamin D3 using 5000 to 50,000 international units a day in long-term hospitalized patients: insights from a seven year experience", "author": "McCullough", "doi-asserted-by": "crossref", "first-page": "228", "journal-title": "J Steroid Biochem Mol Biol", "key": "10.1016/j.eprac.2021.09.016_bib37", "volume": "189", "year": "2019" } ], "reference-count": 36, "references-count": 36, "relation": {}, 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