Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Lactoferrin  COVID-19 treatment studies for Lactoferrin  C19 studies: Lactoferrin  Lactoferrin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro
Salaris et al., Nutrients, doi:10.3390/nu13020328 (In Vitro)
Salaris et al., Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro, Nutrients, doi:10.3390/nu13020328 (In Vitro)
Jan 2021   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Caco-2 and Vero E6 In Vitro study showing lactoferrin enhances the antiviral immune response, partially inhibits SARS-CoV-2 infection in Caco-2 intestinal epithelial cells, and modulates cytokine production.
5 In Vitro studies support the efficacy of lactoferrin [Cutone, Mirabelli, Ostrov, Piacentini, Salaris].
Salaris et al., 23 Jan 2021, peer-reviewed, 9 authors.
Contact: paola.brun.1@unipd.it (corresponding author), claudio.salaris@studenti.unipd.it, alice.bertolini@studenti.unipd.it, ignazio.castagliuolo@unipd.it, melania.scarpa@iov.veneto.it, marina.elli@aat-taa.eu, simone.guglielmetti@unimi.it, fabrizio.pregliasco@unimi.it, corrado.blandizzi@med.unipi.it.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperLactoferrinAll
Abstract: nutrients Article Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro Claudio Salaris 1,† , Melania Scarpa 2,† , Marina Elli 3 , Alice Bertolini 1 , Simone Guglielmetti 4 , Fabrizio Pregliasco 5 , Corrado Blandizzi 6 , Paola Brun 1, * and Ignazio Castagliuolo 1 1 2 3 4 5 6 * †   Citation: Salaris, C.; Scarpa, M.; Elli, M.; Bertolini, A.; Guglielmetti, S.; Pregliasco, F.; Blandizzi, C.; Brun, P.; Castagliuolo, I. Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro. Nutrients 2021, 13, 328. https://doi.org/10.3390/ Department of Molecular Medicine, University of Padua, 35121 Padua, Italy; claudio.salaris@studenti.unipd.it (C.S.); alice.bertolini@studenti.unipd.it (A.B.); ignazio.castagliuolo@unipd.it (I.C.) Laboratory of Advanced Translational Research, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy; melania.scarpa@iov.veneto.it AAT-Advanced Analytical Technologies S.r.l., Fiorenzuola d’Arda, 29122 Piacenza, Italy; marina.elli@aat-taa.eu Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, 20122 Milan, Italy; simone.guglielmetti@unimi.it IRCCS Istituto Ortopedico Galeazzi, University of Milan, 20136 Milan, Italy; fabrizio.pregliasco@unimi.it Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy; corrado.blandizzi@med.unipi.it Correspondence: paola.brun.1@unipd.it These authors contributed equally to this work. Abstract: SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response gene expression was analyzed by qRT-PCR in uninfected Caco-2 intestinal epithelial cells treated with LF. An infection assay for SARS-CoV-2 was performed in Caco-2 cells treated or not with LF. SARS-CoV-2 titer was determined by qRT-PCR, plaque assay and immunostaining. Inflammatory and anti-inflammatory cytokine production was determined by qRT-PCR. LF significantly induced the expression of IFNA1, IFNB1, TLR3, TLR7, IRF3, IRF7 and MAVS genes. Furthermore, LF partially inhibited SARS-CoV-2 infection and replication in Caco-2 intestinal epithelial cells. Our in vitro data support LF as an immune modulator of the antiviral immune response with moderate effects against SARS-CoV-2 infection. nu13020328 Keywords: lactoferrin; SARS-CoV-2; antiviral immunity; COVID-19 Received: 16 December 2020 Accepted: 21 January 2021 Published: 23 January 2021
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit