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Liposomal Lactoferrin Exerts Antiviral Activity against HCoV-229E and SARS-CoV-2 Pseudoviruses In Vitro

Andreu et al., Viruses, doi:10.3390/v15040972
Apr 2023  
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In Vitro study showing more potent antiviral activity for SARS-CoV-2 and HCoV229E with liposomal lactoferrin compared with free lactoferrin. Authors note that liposomal encapsulation has been shown to increase permeability, bioavailability, and time release.
Andreu et al., 15 Apr 2023, Spain, peer-reviewed, 4 authors. Contact: (corresponding author),,,
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperLactoferrinAll
AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for lactoferrin.

Liposomal lactoferrin was more effective than free lactoferrin at inhibiting HCoV-229E and SARS-CoV-2 pseudoviruses.

This article discusses the potential use of liposomal lactoferrin (Lf) as an antiviral treatment for COVID-19. Lf is a protein that is naturally found in human milk, saliva, and tears. It has a variety of beneficial properties, including anti-inflammatory, antioxidant, and immune-modulating effects. In vitro studies have shown that Lf can inhibit the growth of a variety of viruses, including SARS-CoV-2.

In the present study, the authors investigated the antiviral activity of liposomal Lf against HCoV-229E and SARS-CoV-2 pseudoviruses. They found that liposomal Lf was more effective than free Lf at inhibiting the growth of both viruses.

The authors conclude that liposomal Lf is a promising candidate for the development of an antiviral treatment for COVID-19. Further studies are needed to determine the efficacy and safety of liposomal Lf in humans.

Here are some additional details from the article:

  • Lf is a multifunctional protein that has been shown to have antiviral, anti-inflammatory, and immunomodulatory effects.
  • In vitro studies have shown that Lf can inhibit the growth of a variety of viruses, including SARS-CoV-2.
  • The authors of the present study found that liposomal Lf was more effective than free Lf at inhibiting the growth of HCoV-229E and SARS-CoV-2 pseudoviruses.
  • The authors conclude that liposomal Lf is a promising candidate for the development of an antiviral treatment for COVID-19.
Liposomal Lactoferrin Exerts Antiviral Activity against HCoV-229E and SARS-CoV-2 Pseudoviruses In Vitro
Sabina Andreu, Inés Ripa, Raquel Bello-Morales, José Antonio López-Guerrero
Viruses, doi:10.3390/v15040972
A limited number of effective therapies are currently available to treat human coronavirus SARS-CoV-2 and other human coronaviruses, which are responsible for nearly a third of global cases of the common cold. The possibility of new emerging coronaviruses demands powerful new antiviral strategies. Lactoferrin is a well-known protein that possesses anti-inflammatory and immunomodulatory activities, and it has previously shown antiviral activity against several viruses, including SARS-CoV-2. To increase this antiviral activity, here we present bovine liposomal lactoferrin. Liposomal encapsulation of the compound was proven to increase permeability, bioavailability, and time release. In the present work, we compare the antiviral activity of free and liposomal bovine lactoferrin against HCoV229E and SARS-CoV-2 in vitro and in human primary bronchial epithelial cells, and we demonstrated that the liposomal form exerts a more potent antiviral activity than its free form at non-cytotoxic doses.
Informed Consent Statement: Written informed consent was obtained from the patient(s) to publish this paper. Conflicts of Interest: The authors declare no conflict of interest.
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