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Bovine lactoferrin suppresses the cathepsin-dependent pathway of SARS-CoV-2 entry in vitro

Kobayashi-Sakamoto et al., International Dairy Journal, doi:10.1016/j.idairyj.2023.105805
Sep 2023  
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In Vitro study showing variant dependent inhibition of SARS-CoV-2 with bovine lactoferrin (bLF). Authors found that bLF did not suppress entry of wild-type pseudoviruses into cells that express both ACE2 and TMPRSS2, but did suppress entry of Omicron pseudoviruses. bLF suppressed entry of wild-type pseudoviruses into ACE2-expressing cells but not into TMPRSS2-expressing cells.
13 preclinical studies support the efficacy of lactoferrin for COVID-19:
Kobayashi-Sakamoto et al., 21 Sep 2023, peer-reviewed, 7 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperLactoferrinAll
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