Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence
Campione et al.,
Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence,
International Journal of Environmental Research and Public Health, doi:10.3390/ijerph182010985
Small prospective study in Italy with 32 lactoferrin patients, 32 SOC, and 28 patients with no treatment, showing significantly faster viral clearance and improved recovery with treatment. Oral and intranasal lactoferrin.
time to viral-, 47.5% lower, relative time 0.53, p < 0.001, treatment 32, control 32, vs. SOC.
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time to viral-, 56.3% lower, relative time 0.44, p < 0.001, treatment 32, control 28, vs. untreated.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Campione et al., 19 Oct 2021, prospective, Italy, peer-reviewed, 32 authors.
Abstract: International Journal of
Environmental Research
and Public Health
Article
Lactoferrin as Antiviral Treatment in COVID-19 Management:
Preliminary Evidence
Elena Campione 1, *, Caterina Lanna 1 , Terenzio Cosio 1 , Luigi Rosa 2 , Maria Pia Conte 2 , Federico Iacovelli 3 ,
Alice Romeo 3 , Mattia Falconi 3 , Claudia Del Vecchio 4 , Elisa Franchin 4 , Maria Stella Lia 5 , Marilena Minieri 5 ,
Carlo Chiaramonte 6 , Marco Ciotti 7 , Marzia Nuccetelli 8 , Alessandro Terrinoni 5 , Ilaria Iannuzzi 9 ,
Luca Coppeta 9 , Andrea Magrini 9 , Sergio Bernardini 8 , Stefano Sabatini 10 , Felice Rosapepe 11 ,
Pier Luigi Bartoletti 12 , Nicola Moricca 10 , Andrea Di Lorenzo 13 , Massimo Andreoni 13 , Loredana Sarmati 13 ,
Alessandro Miani 14 , Prisco Piscitelli 15 , Ettore Squillaci 16 , Piera Valenti 2,† and Luca Bianchi 1,†
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Citation: Campione, E.; Lanna, C.;
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Cosio, T.; Rosa, L.; Conte, M.P.;
Iacovelli, F.; Romeo, A.; Falconi, M.;
Del Vecchio, C.; Franchin, E.; et al.
Lactoferrin as Antiviral Treatment in
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COVID-19 Management: Preliminary
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Evidence. Int. J. Environ. Res. Public
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Health 2021, 18, 10985. https://
doi.org/10.3390/ijerph182010985
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Academic Editor: Paul B. Tchounwou
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Received: 4 August 2021
Accepted: 13 October 2021
Published: 19 October 2021
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Dermatology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy;
caterinalanna.cl@gmail.com (C.L.); terenziocosio@gmail.com (T.C.); luca.bianchi@uniroma2.it (L.B.)
Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185 Rome, Italy;
luigi.rosa@uniroma1.it (L.R.); mariapia.conte@uniroma1.it (M.P.C.); piera.valenti@uniroma1.it (P.V.)
Structural Bioinformatics Group, Department of Biology, University of Rome “Tor Vergata”,
00133 Rome, Italy; federico.iacovelli@uniroma2.it (F.I.); alice.romeo@uniroma2.it (A.R.);
falconi@uniroma2.it (M.F.)
Department of Molecular Medicine, University of Padova, 35122 Padova, Italy;
claudia.delvecchio@unipd.it (C.D.V.); elisa.franchin@unipd.it (E.F.)
Department of Experimental Medicine, Tor Vergata University Hospital, 00133 Rome, Italy;
lia.mariastella@gmail.com (M.S.L.); minieri@med.uniroma2.it (M.M.); alessandro.terrinoni@uniroma2.it (A.T.)
Department of Statistics, University of Rome Tor Vergata, 00133 Rome, Italy; chiaramonte.carlo43@gmail.com
Virology Unit, Tor Vergata University Hospital, 00133 Rome, Italy; marco.ciotti@ptvonline.it
Laboratory Medicine, Department of Experimental Medicine and Surgery, Tor Vergata University Hospital,
00133 Rome, Italy; marzianuccetelli@yahoo.com (M.N.); bernardini@med.uniroma2.it (S.B.)
Occupational Medicine Department, University of Rome “Tor Vergata”, 00133 Rome, Italy;
ilariaiannuzzi@gmail.com (I.I.); luca.coppeta@gmail.com (L.C.); andrea.magrini@uniroma2.it (A.M.)
Villa dei Pini Hospital, 00042 Anzio, Italy; stefanosabatini@gmail.com (S.S.); nicolamoricca@gmail.com (N.M.)
Pineta Grande Hospital, 81030 Caserta, Italy; frosapepe@gmail.com
Fimmg Provincial, 00144 Rome, Italy; pl.bartoletti@gmail.com
Infectious Disease Unit, Tor Vergata University Hospital, 00133 Rome, Italy;
andrea.dilorenzo@alumni.uniroma2.eu (A.D.L.); andreoni@uniroma2.it (M.A.);
sarmati@med.uniroma2.it (L.S.)
Department of Environmental Sciences and Policy, University of Milan, 20133 Milan, Italy;
alessandro.miani@unimi.it
UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico..
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