Abstract: International Journal of Environmental Research and Public Health Article Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence Elena Campione 1, *, Caterina Lanna 1 , Terenzio Cosio 1 , Luigi Rosa 2 , Maria Pia Conte 2 , Federico Iacovelli 3 , Alice Romeo 3 , Mattia Falconi 3 , Claudia Del Vecchio 4 , Elisa Franchin 4 , Maria Stella Lia 5 , Marilena Minieri 5 , Carlo Chiaramonte 6 , Marco Ciotti 7 , Marzia Nuccetelli 8 , Alessandro Terrinoni 5 , Ilaria Iannuzzi 9 , Luca Coppeta 9 , Andrea Magrini 9 , Sergio Bernardini 8 , Stefano Sabatini 10 , Felice Rosapepe 11 , Pier Luigi Bartoletti 12 , Nicola Moricca 10 , Andrea Di Lorenzo 13 , Massimo Andreoni 13 , Loredana Sarmati 13 , Alessandro Miani 14 , Prisco Piscitelli 15 , Ettore Squillaci 16 , Piera Valenti 2,† and Luca Bianchi 1,† 1 2 3 4 5



 Citation: Campione, E.; Lanna, C.; 6 7 8 Cosio, T.; Rosa, L.; Conte, M.P.; Iacovelli, F.; Romeo, A.; Falconi, M.; Del Vecchio, C.; Franchin, E.; et al. Lactoferrin as Antiviral Treatment in 9 10 11 COVID-19 Management: Preliminary 12 Evidence. Int. J. Environ. Res. Public 13 Health 2021, 18, 10985. https:// doi.org/10.3390/ijerph182010985 14 Academic Editor: Paul B. Tchounwou 15 Received: 4 August 2021 Accepted: 13 October 2021 Published: 19 October 2021 16 * † Dermatology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy; caterinalanna.cl@gmail.com (C.L.); terenziocosio@gmail.com (T.C.); luca.bianchi@uniroma2.it (L.B.) Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185 Rome, Italy; luigi.rosa@uniroma1.it (L.R.); mariapia.conte@uniroma1.it (M.P.C.); piera.valenti@uniroma1.it (P.V.) Structural Bioinformatics Group, Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy; federico.iacovelli@uniroma2.it (F.I.); alice.romeo@uniroma2.it (A.R.); falconi@uniroma2.it (M.F.) Department of Molecular Medicine, University of Padova, 35122 Padova, Italy; claudia.delvecchio@unipd.it (C.D.V.); elisa.franchin@unipd.it (E.F.) Department of Experimental Medicine, Tor Vergata University Hospital, 00133 Rome, Italy; lia.mariastella@gmail.com (M.S.L.); minieri@med.uniroma2.it (M.M.); alessandro.terrinoni@uniroma2.it (A.T.) Department of Statistics, University of Rome Tor Vergata, 00133 Rome, Italy; chiaramonte.carlo43@gmail.com Virology Unit, Tor Vergata University Hospital, 00133 Rome, Italy; marco.ciotti@ptvonline.it Laboratory Medicine, Department of Experimental Medicine and Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; marzianuccetelli@yahoo.com (M.N.); bernardini@med.uniroma2.it (S.B.) Occupational Medicine Department, University of Rome “Tor Vergata”, 00133 Rome, Italy; ilariaiannuzzi@gmail.com (I.I.); luca.coppeta@gmail.com (L.C.); andrea.magrini@uniroma2.it (A.M.) Villa dei Pini Hospital, 00042 Anzio, Italy; stefanosabatini@gmail.com (S.S.); nicolamoricca@gmail.com (N.M.) Pineta Grande Hospital, 81030 Caserta, Italy; frosapepe@gmail.com Fimmg Provincial, 00144 Rome, Italy; pl.bartoletti@gmail.com Infectious Disease Unit, Tor Vergata University Hospital, 00133 Rome, Italy; andrea.dilorenzo@alumni.uniroma2.eu (A.D.L.); andreoni@uniroma2.it (M.A.); sarmati@med.uniroma2.it (L.S.) Department of Environmental Sciences and Policy, University of Milan, 20133 Milan, Italy; alessandro.miani@unimi.it UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico..