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Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach

Pandya et al., Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.100951
Apr 2022  
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In Silico study showing significant interaction with SARS-CoV-2 targets for multiple vitamins.
14 preclinical studies support the efficacy of vitamin B9 for COVID-19:
Vitamin B9 has been identified by the European Food Safety Authority (EFSA) as having sufficient evidence for a causal relationship between intake and optimal immune system function12-14. Vitamin B9 inhibits SARS-CoV-2 In Silico3-11, reduces spike protein binding ability11, binds with the spike protein receptor binding domain for alpha and omicron variants2, inhibits the SARS-CoV-2 nucleocapsid protein3, inhibits 3CLpro and PLpro in enzymatic assays2, significantly reduces infection for alpha and omicron SARS-CoV-2 pseudoviruses2, and inhibits ACE2 expression and SARS-CoV-2 infection in a mouse model11.
Study covers vitamin D, vitamin C, vitamin A, vitamin B9, and vitamin B12.
Pandya et al., 20 Apr 2022, peer-reviewed, 9 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperVitamin B9All
Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach
Medha Pandya, Sejal Shah, Tanzil Juneja, Amisha Patel, Ayushman Gadnayak, Sushma Dave, Kajari Das, Jayashankar Das
Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.100951
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Ethical statement The study does not involve the animals. Declaration of competing interest The authors declare no competing interests.
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