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All Studies   Meta Analysis    Recent:   

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

Chen et al., Pharmaceutical Biology, doi:10.1080/13880209.2022.2063341
May 2022  
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In Silico and In Vitro study identifying folic acid as a potential inhibitor of the SARS-CoV-2 nucleocapsid protein.
13 preclinical studies support the efficacy of vitamin B9 for COVID-19:
Vitamin B9 has been identified by the European Food Safety Authority (EFSA) as having sufficient evidence for a causal relationship between intake and optimal immune system function EFSA, Galmés, Galmés (B). Vitamin B9 inhibits SARS-CoV-2 In Silico Chen, Eskandari, Hosseini, Kumar, Moatasim, Pandya, Serseg, Ugurel, Zhang, reduces spike protein binding ability Zhang, binds with the spike protein receptor binding domain for alpha and omicron variants Pennisi, inhibits the SARS-CoV-2 nucleocapsid protein Chen, inhibits 3CLpro and PLpro in enzymatic assays Pennisi, significantly reduces infection for alpha and omicron SARS-CoV-2 pseudoviruses Pennisi, and inhibits ACE2 expression and SARS-CoV-2 infection in a mouse model Zhang.
Chen et al., 20 May 2022, peer-reviewed, 7 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperVitamin B9All
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein
Yu-Meng Chen, Jin-Lai Wei, Rui-Si Qin, Jin-Ping Hou, Guang-Chao Zang, Guang-Yuan Zhang, Ting-Ting Chen
Pharmaceutical Biology, doi:10.1080/13880209.2022.2063341
Context: Coronavirus disease 2019 is a global pandemic. Studies suggest that folic acid has antiviral effects. Molecular docking shown that folic acid can act on SARS-CoV-2 Nucleocapsid Phosphoprotein (SARS-CoV-2 N). Objective: To identify novel molecular therapeutic targets for SARS-CoV-2. Materials and methods: Traditional Chinese medicine targets and virus-related genes were identified with network pharmacology and big data analysis. Folic acid was singled out by molecular docking, and its potential target SARS-CoV-2 N was identified. Inhibition of SARS-CoV-2 N of folic acid was verified at the cellular level. Results: In total, 8355 drug targets were potentially involved in the inhibition of SARS-CoV-2. 113 hub genes were screened by further association analysis between targets and virus-related genes. The hub genes related compounds were analysed and folic acid was screened as a potential new drug. Moreover, molecular docking showed folic acid could target on SARS-CoV-2 N which inhibits host RNA interference (RNAi). Therefore, this study was based on RNAi to verify whether folic acid antagonises SARS-CoV-2 N. Cell-based experiments shown that RNAi decreased mCherry expression by 81.7% (p < 0.001). This effect was decreased by 8.0% in the presence of SARS-CoV-2 N, indicating that SARS-CoV-2 N inhibits RNAi. With increasing of folic acid concentration, mCherry expression decreased, indicating that folic acid antagonises the regulatory effect of SARS-CoV-2 N on host RNAi. Discussion and conclusions: Folic acid may be an antagonist of SARS-CoV-2 N, but its effect on viruses unclear. In future, the mechanisms of action of folic acid against SARS-CoV-2 N should be studied.
Disclosure statement The authors declare no conflicts of interest. Author contributions J.P.H. and R.S.Q. performed the bioinformatic analysis. Y.M.C. and J.L.W. wrote the paper; and T.T.C. contributed to the final version of the manuscript, as well as read and approved it; the rest of the authors contributed to the modification of the manuscript. All authors read and approved the manuscript.
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