Impact of Vitamin D Levels on Clinical Outcomes in SARS-CoV-2 Infections
Mouad Najih, Rihab Boussettine, Mohamed S El Kehel, Kawtar Nabil, Hasna Azmi, Hind Berradi, Moulay Mustapha Ennaji
Cureus, doi:10.7759/cureus.78291
Background and aim: Since its emergence in 2019, SARS-CoV-2 has caused the global COVID-19 pandemic, presenting significant challenges for healthcare systems worldwide. Extensive research has focused on diagnostics, treatments, and vaccine development to combat the virus. Given the need for effective strategies to reduce infection rates, disease progression, and severity, this study aimed to investigate the potential role of vitamin D (25OHD) in mitigating the severity of COVID-19. Methods: A cross-sectional study was conducted to evaluate the relationship between serum vitamin D levels and the severity of COVID-19 symptoms. Vitamin D levels were measured using the Roche Diagnostics Vitamin D assay in 100 SARS-CoV-2-infected patients confirmed by real-time polymerase chain reaction (PCR). Patients were categorized as symptomatic or asymptomatic, and the correlation between vitamin D levels and symptom severity was analyzed. Results: The findings demonstrated that a significant proportion of symptomatic patients had vitamin D levels below 20 ng/mL. In contrast, approximately 25% of asymptomatic patients had vitamin D levels exceeding 30 ng/mL. Statistical analysis confirmed a significant association between low vitamin D levels and increased symptom severity (p=0.007). Conclusion: This study suggests that vitamin D deficiency may contribute to the severity of COVID-19 symptoms. Vitamin D supplementation could potentially reduce the risk of severe disease. However, to confirm these findings and support these recommendations, further research, including randomized controlled trials and large-scale population studies, is necessary.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work.
Concept and design:
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