All Studies Meta Analysis

Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease

De Nicolò et al., Nutrients, doi:10.3390/nu15010169

Dec 2022

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Download Image

Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Prospective study of 106 IBD patients in Italy, showing lower risk of IgG positivity with vitamin D supplementation. Vitamin D levels below 30 ng/mL were associated with a higher probability of symptomatic cases.

This is the 104th of 122 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 587 sextillion).

30 studies are RCTs, which show efficacy with p=0.0000032.

Important missing comments or errors? Let us know.

risk of IgG positive, 88.4% lower, OR 0.12, p = 0.002, treatment 43, control 63, adjusted per study, multivariable, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

De Nicolò et al., 29 Dec 2022, prospective, Italy, peer-reviewed, 11 authors, study period January 2021 - April 2021, dosage not specified. Contact: amedeo.denicolo@unito.it (corresponding author).

This Paper Vitamin D All

Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease

Amedeo De Nicolò, Jessica Cusato, Cristina Bezzio, Simone Saibeni, Marta Vernero, Michela Disabato, Gian Paolo Caviglia, Alice Ianniello, Alessandra Manca, Antonio D’avolio, Davide Giuseppe Ribaldone

Nutrients, doi:10.3390/nu15010169

The coronavirus disease (COVID-19) pandemic represents a global health challenge, particularly considering concomitant diseases. Patients with inflammatory bowel diseases (IBD) can be considered a population at risk. On the other hand, the risk of developing IBD and COVID-19 have both been described as modulated by vitamin D (VD) levels. In this work, a cohort of 106 adult patients affected by IBD was prospectively enrolled, during the second wave of the pandemic in Italy. In these patients, VD plasma levels, demographic, and clinical characteristics were tested for a correlation/an association with the risk of infection with SARS-CoV-2 in the study period (antispike IgG positivity) and the severity of COVID-19 symptoms. By multivariate logistic regression analysis, VD supplementation (Odds Ratio; OR 0.116, p = 0.002), therapy with monoclonal antibodies (OR 0.227, p = 0.007), and the use of mesalazine (OR 2.968, p = 0.046) were found to be independent predictors of SARS-CoV-2 positivity. Moreover, hypertension was associated with severe disease (p = 0.019), while a VD level higher than 30 ng/mL (p = 0.031, OR 0.078) was associated with asymptomatic infection. No interplay between IBD activity and COVID-19 risk of infection or symptoms was observed. These results confirm the importance of VD levels in defining the risk of COVID-19 and give encouraging data about the safety of maintaining immunomodulatory treatments for IBD during the COVID-19 pandemic.

Conflicts of Interest: The authors declare no conflict of interest.

References

Anbarcioglu, Kirtiloglu, Ozturk, Kolbakir, Acikgoz et al., Vitamin D deficiency in patients with aggressive periodontitis, Oral Dis, doi:10.1111/odi.12968

Arboleda, Urcuqui-Inchima, Vitamin, Supplementation: A Potential Approach for Coronavirus/COVID-19 Therapeutics? Front, Immunol, doi:10.3389/fimmu.2020.01523

Arora, Patel, Nicol, Field, Restori et al., Vitamin D and the Ability to Produce 1,25(OH)(2)D Are Critical for Protection from Viral Infection of the Lungs, Nutrients, doi:10.3390/nu14153061

Azrielant, Shoenfeld, Vitamin D and the Immune System, Isr. Med. Assoc. J

Balestrieri, Ribolsi, Guarino, Emerenziani, Altomare et al., Nutritional Aspects in Inflammatory Bowel Diseases, Nutrients, doi:10.3390/nu12020372

Benskin, A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency, Front. Public Health, doi:10.3389/fpubh.2020.00513

Bezzio, Armuzzi, Furfaro, Ardizzone, Milla et al., Therapies for inflammatory bowel disease do not pose additional risks for adverse outcomes of SARS-CoV-2 infection: An IG-IBD study, Aliment. Pharmacol. Ther, doi:10.1111/apt.16663

Bezzio, Saibeni, Variola, Allocca, Massari et al., Outcomes of COVID-19 in 79 patients with IBD in Italy: An IG-IBD study, Gut, doi:10.1136/gutjnl-2020-321411

Boglione, Cusato, De Nicolo, Cariti, Di Perri et al., Role of CYP27B1+2838 promoter polymorphism in the treatment of chronic hepatitis B HBeAg negative with PEG-interferon, J. Viral Hepat, doi:10.1111/jvh.12288

Calcagno, Ghisetti, Emanuele, Trunfio, Faraoni et al., Risk for SARS-CoV-2 Infection in Healthcare Workers, Emerg. Infect. Dis, doi:10.3201/eid2701.203027

Cascella, Rajnik, Aleem, Dulebohn, Di Napoli et al., Evaluation, and Treatment of Coronavirus (COVID-19

Castillo, Entrenas Costa, Vaquero Barrios, Alcala Diaz, Lopez Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751

Chauss, Freiwald, Mcgregor, Yan, Wang et al., Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells, Nat. Immunol, doi:10.1038/s41590-021-01080-3

Coperchini, Ricci, Croce, Denegri, Ruggiero et al., Modulation of ACE-2 mRNA by inflammatory cytokines in human thyroid cells: A pilot study, Endocrine, doi:10.1007/s12020-021-02807-w

Courbebaisse, Cavalier, Vitamin, in 2020: An Old Pro-Hormone with Potential Effects beyond Mineral Metabolism, Nutrients, doi:10.3390/nu12113378

Cusato, Allegra, Boglione, De Nicolo, Baietto et al., Vitamin D pathway gene variants and HCV-2/3 therapy outcomes, Antivir. Ther, doi:10.3851/IMP2853

D'avolio, Avataneo, Manca, Cusato, De Nicolo et al., 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2, Nutrients, doi:10.3390/nu12051359

De Nicolò, Avataneo, Cusato, Palermiti, Mula et al., Analytical Validation and Clinical Application of Rapid Serological Tests for SARS-CoV-2 Suitable for Large-Scale Screening, Diagnostics, doi:10.3390/diagnostics11050869

Dickie, Church, Coulthard, Mathews, Emery et al., Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes, Rheumatology, doi:10.1093/rheumatology/keq124

Dipasquale, Lo Presti, Milani, Corsello, Agostoni et al., Vitamin D in Prevention of Autoimmune Diseases, Front. Biosci. Landmark, doi:10.31083/j.fbl2710288

Dragasevic, Stankovic, Kotur, Milutinovic, Milovanovic et al., Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease, Life, doi:10.3390/life12101623

Ecco, Update on COVID-19 and IBD

Gallelli, Mannino, Luciani, De Sire, Mancuso et al., Vitamin D Serum Levels in Subjects Tested for SARS-CoV-2: What Are the Differences among Acute, Healed, and Negative COVID-19 Patients? A Multicenter Real-Practice Study, Nutrients, doi:10.3390/nu13113932

Gibbons, Norton, Mccullough, Meltzer, Lavigne et al., Association between vitamin D supplementation and COVID-19 infection and mortality, Sci. Rep, doi:10.1038/s41598-022-24053-4

Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline, J. Clin. Endocrinol. Metab, doi:10.1210/jc.2011-0385

Holick, The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention, Rev. Endocr. Metab. Disord, doi:10.1007/s11154-017-9424-1

Huang, Lian, Song, Ma, Lian et al., Clinical features of severe patients infected with 2019 novel coronavirus: A systematic review and meta-analysis, Ann. Transl. Med, doi:10.21037/atm-20-2124

Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci. Rep, doi:10.1038/s41598-020-77093-z

Jin, Lian, Hu, Gao, Zheng et al., Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms, Gut, doi:10.1136/gutjnl-2020-320926

Katz, Yue, Xue, Increased risk for COVID-19 in patients with vitamin D deficiency, Nutrition, doi:10.1016/j.nut.2020.111106

Kolls, Garry, Role of the T cell vitamin D receptor in severe COVID-19, Nat. Immunol, doi:10.1038/s41590-021-01098-7

Lu, Clinical presentations of inflammatory bowel disease: East meets West, J. Chin. Med. Assoc, doi:10.1016/j.jcma.2016.09.005

Maaser, Sturm, Vavricka, Kucharzik, Fiorino et al., ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications, J. Crohns Colitis, doi:10.1093/ecco-jcc/jjy113

Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE, doi:10.1371/journal.pone.0239799

Martineau, Cantorna, Vitamin D for COVID-19: Where are we now?, Nat. Rev. Immunol, doi:10.1038/s41577-022-00765-6

Martineau, Vitamin D in the prevention or treatment of COVID-19, Proc. Nutr. Soc, doi:10.1017/S0029665122002798

Matheu, Back, Mondoc, Issazadeh-Navikas, Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: Enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease, J. Allergy Clin. Immunol, doi:10.1016/s0091-6749

Mehta, Gracias, Croft, TNF activity and T cells, Cytokine, doi:10.1016/j.cyto.2016.08.003

Meltzer, Best, Zhang, Vokes, Arora et al., Association of Vitamin D Status and Other Clinical Characteristics with COVID-19 Test Results, JAMA Netw. Open, doi:10.1001/jamanetworkopen.2020.19722

Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J. Med. Virol, doi:10.1002/jmv.26360

Murai, Fernandes, Antonangelo, Gualano, Pereira, Effect of a Single High-Dose Vitamin D3 on the Length of Hospital Stay of Severely 25-Hydroxyvitamin D-Deficient Patients with COVID-19, Clinics, doi:10.6061/clinics/2021/e3549

Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA, doi:10.1001/jama.2020.26848

Neurath, COVID-19 and immunomodulation in IBD, Gut, doi:10.1136/gutjnl-2020-321269

Sanson, De Nicolo, Zerbato, Segat, Koncan et al., A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients, Ir. J. Med. Sci, doi:10.1007/s11845-022-02952-9

Sekine, Perez-Potti, Rivera-Ballesteros, Stralin, Gorin et al., Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19, Cell, doi:10.1016/j.cell.2020.08.017

Siew, Hilmi, Blake, Bhayat, Adsul et al., Low Frequency of Opportunistic Infections in Patients Receiving Vedolizumab in Clinical Trials and Post-Marketing Setting, Inflamm. Bowel Dis, doi:10.1093/ibd/izy153

Vatn, Sandvik, Inflammatory bowel disease, Scand. J. Gastroenterol, doi:10.3109/00365521.2015.1033000

Villasis-Keever, Lopez-Alarcon, Miranda-Novales, Zurita-Cruz, Barrada-Vazquez et al., Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial, Arch. Med. Res, doi:10.1016/j.arcmed.2022.04.003

Wang, Wang, Li, Chen, Han et al., Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone, ACS Infect. Dis, doi:10.1021/acsinfecdis.1c00096

Wong, Lui, Sung, Covid-19 and the digestive system, J. Gastroenterol. Hepatol, doi:10.1111/jgh.15047

Wu, Chen, Cai, Xia, Zhou et al., Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China, JAMA Intern. Med, doi:10.1001/jamainternmed.2020.0994

Wu, Liu, Deng, The Role of Vitamin D in Immune System and Inflammatory Bowel Disease, J. Inflamm. Res, doi:10.2147/JIR.S363840

Zhang, Leung, Richers, Liu, Remigio et al., Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1, J. Immunol, doi:10.4049/jimmunol.1102412

Zhang, Wu, Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis, Neurosci. Bull, doi:10.1007/s12264-010-0731-8

Zhao, Zhang, Wu, Li, Liu et al., Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice, BMC Gastroenterol, doi:10.1186/1471-230X-12-57

Zurita-Cruz, Fonseca-Tenorio, Villasis-Keever, Lopez-Alarcon, Parra-Ortega et al., Efficacy and safety of vitamin D supplementation in hospitalized COVID-19 pediatric patients: A randomized controlled trial, Front. Pediatr, doi:10.3389/fped.2022.943529

{ 'indexed': { 'date-parts': [[2022, 12, 31]], 'date-time': '2022-12-31T06:10:30Z', 'timestamp': 1672467030516}, 'reference-count': 0, 'publisher': 'MDPI AG', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 12, 29]], 'date-time': '2022-12-29T00:00:00Z', 'timestamp': 1672272000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': 'The coronavirus disease (COVID-19) pandemic represents a global health challenge, ' 'particularly considering concomitant diseases. Patients with inflammatory bowel diseases ' '(IBD) can be considered a population at risk. On the other hand, the risk of developing IBD ' 'and COVID-19 have both been described as modulated by vitamin D (VD) levels. In this work, a ' 'cohort of 106 adult patients affected by IBD was prospectively enrolled, during the second ' 'wave of the pandemic in Italy. In these patients, VD plasma levels, demographic, and clinical ' 'characteristics were tested for a correlation/an association with the risk of infection with ' 'SARS-CoV-2 in the study period (anti-spike IgG positivity) and the severity of COVID-19 ' 'symptoms. By multivariate logistic regression analysis, VD supplementation (Odds Ratio; OR ' '0.116, p = 0.002), therapy with monoclonal antibodies (OR 0.227, p = 0.007), and the use of ' 'mesalazine (OR 2.968, p = 0.046) were found to be independent predictors of SARS-CoV-2 ' 'positivity. Moreover, hypertension was associated with severe disease (p = 0.019), while a VD ' 'level higher than 30 ng/mL (p = 0.031, OR 0.078) was associated with asymptomatic infection. ' 'No interplay between IBD activity and COVID-19 risk of infection or symptoms was observed. ' 'These results confirm the importance of VD levels in defining the risk of COVID-19 and give ' 'encouraging data about the safety of maintaining immunomodulatory treatments for IBD during ' 'the COVID-19 pandemic.', 'DOI': '10.3390/nu15010169', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 12, 30]], 'date-time': '2022-12-30T08:18:18Z', 'timestamp': 1672388298000}, 'page': '169', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and ' 'COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease', 'prefix': '10.3390', 'volume': '15', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-5973-9948', 'authenticated-orcid': False, 'given': 'Amedeo De', 'family': 'De Nicolò', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1977-9694', 'authenticated-orcid': False, 'given': 'Jessica', 'family': 'Cusato', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cristina', 'family': 'Bezzio', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simone', 'family': 'Saibeni', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-6904-7638', 'authenticated-orcid': False, 'given': 'Marta', 'family': 'Vernero', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michela', 'family': 'Disabato', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gian Paolo', 'family': 'Caviglia', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Ianniello', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8540-6709', 'authenticated-orcid': False, 'given': 'Alessandra', 'family': 'Manca', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1321-4126', 'authenticated-orcid': False, 'given': 'Antonio', 'family': 'D’Avolio', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-9421-3087', 'authenticated-orcid': False, 'given': 'Davide Giuseppe', 'family': 'Ribaldone', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2022, 12, 29]]}, 'container-title': 'Nutrients', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/2072-6643/15/1/169/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 30]], 'date-time': '2022-12-30T08:55:24Z', 'timestamp': 1672390524000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2072-6643/15/1/169'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 12, 29]]}, 'references-count': 0, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 1]]}}, 'alternative-id': ['nu15010169'], 'URL': 'http://dx.doi.org/10.3390/nu15010169', 'relation': {}, 'ISSN': ['2072-6643'], 'subject': ['Food Science', 'Nutrition and Dietetics'], 'container-title-short': 'Nutrients', 'published': {'date-parts': [[2022, 12, 29]]}}

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0