A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients
Sanson et al.
, A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in..
, Irish Journal of Medical Science (1971 -), doi:10.1007/s11845-022-02952-9
Prospective study of 69 hospitalized COVID-19 pneumonia patients, showing higher risk of combined NIV/IMV/60-day death with low vitamin D levels.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
NIV/IMV/death, 64.0% lower, RR 0.36, p = 0.03, high D levels (≥30ng/mL) 2 of 9 (22.2%), low D levels (<30ng/mL) 37 of 60 (61.7%), NNT 2.5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sanson et al., 19 Feb 2022, prospective, Italy, peer-reviewed, 13 authors, study period March 2020 - September 2020.
Abstract: Irish Journal of Medical Science (1971 -)
A combined role for low vitamin D and low albumin circulating levels
as strong predictors of worse outcome in COVID‑19 patients
Gianfranco Sanson1 · Amedeo De Nicolò2 · Verena Zerbato3 · Ludovica Segat4 · Raffaella Koncan4
Stefano Di Bella1,3,8 · Jessica Cusato2 · Alessandra di Masi5 · Andrea Palermo6 · Pietro Caironi7 ·
Pierlanfranco D’Agaro4 · Roberto Luzzati1,3 · Antonio D’Avolio2
Received: 28 August 2021 / Accepted: 8 February 2022
© The Author(s) 2022
Purpose We aimed to assess the combined role of vitamin D and albumin serum levels as predictors of COVID-19 disease
Methods We conducted a prospective observational study on adult patients hospitalized for SARS-CoV-2 pneumonia
(March–September 2020). Vitamin D and albumin serum levels were measured on admission. These variables were categorized in albumin < 3.5 or ≥ 3.5 g/dL and vitamin D < 30 ng/mL or ≥ 30 ng/mL. We excluded patients with known bone
diseases, renal failure, hypercalcemia and/or treated with antiepileptic drugs and steroids, and patients who received previous
vitamin D supplementation. A composite outcome including any ventilatory support, P
aO2/FiO2 ratio, and 60-day mortality
Results Sixty-nine patients were enrolled, of whom 50% received non-invasive (NIV) or invasive mechanical ventilation
(IMV), 10% died, whereas 89% and 66% presented low albumin and low vitamin D serum levels, respectively. No correlation between vitamin D and albumin levels was found. In multivariable logistic regression analyses adjusted for sex and
age-corrected comorbidities, patients having albumin < 3.5 g/dL and vitamin D < 30 ng/mL showed a significant increased
risk for all study outcomes, namely NIV/IMV (OR 3.815; 95% CI 1.122–12.966; p = 0.032), NIV/IMV or death (OR 3.173;
95% CI 1.002–10.043; p = 0.049) and PaO2/FIO2 ≤ 100 (OR 3.410; 95% CI 1.138–10.219; p = 0.029).
Conclusion The measurement of both vitamin D and serum albumin levels on COVID-19 patients’ admission, and their
combined evaluation, provides a simple prognostic tool that could be employed to guide prompt clinical decisions.
Keywords COVID-19 · Human serum albumin · SARS-CoV-2 · Vitamin D
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