Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
Chen et al.,
Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An..,
Infection and Drug Resistance, doi:10.2147/idr.s400561
Retrospective 158 COVID+ patients in China, showing low vitamin D levels associated with slower viral clearance.
viral clearance, 40.0% improved, HR 0.60, p = 0.01, high D levels (≥41.07ng/mL) 52, low D levels (<27.5ng/mL) 53, adjusted per study, tertile 3 vs. tertile 1, multivariable, Cox proportional hazards.
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Chen et al., 28 Feb 2023, retrospective, China, peer-reviewed, 9 authors, study period 1 June, 2022 - 5 July, 2022.
Contact:
pzchen@me.com, guzhidongruijin@163.com.
Abstract: Infection and Drug Resistance
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Plasma 25(OH)D Level is Associated with the
Nucleic Acid Negative Conversion Time of
COVID-19 Patients: An Exploratory Study
Changqiang Chen 1, *, Pu Li 1, *, Jiuming Chen 1, *, Chunxiao Liu 2 , Xiaodan Wang 3 , Jialin Cai 4 ,
Enfei Xiang 4 , Zhidong Gu 1,5 , Peizhan Chen 4
1
Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;
Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department
of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;
4
Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 5Department
of Laboratory Medicine, Ruijin-Hainan Hospital, Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital), Hainan,
People’s Republic of China
2
*These authors contributed equally to this work
Correspondence: Peizhan Chen, Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201821, People’s
Republic of China, Tel +86 13918550745, Email pzchen@me.com; Zhidong Gu, Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai, 201821, People’s Republic of China, Tel +86 13801653534, Email guzhidongruijin@163.com
Purpose: Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and
severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome
for COVID-19 patients is unknown. Here, we aimed to determine the prognostic value of plasma 25(OH)D level in COVID-19
patients.
Patients and Methods: A total of 158 patients infected with novel COVID-19 Omicron variants in Shanghai were recruited in this
study and were categorized into three groups by the tertile levels of plasma 25(OH)D. Plasma 25(OH)D level was determined along
with routine blood tests related to liver and renal functions in newly diagnosed COVID-19 patients at admission. The nucleic acid
negative conversion time of throat swab samples was evaluated as the primary clinical outcome. The prognostic value of clinical
characteristics and plasma 25(OH)D level was assessed using the Kaplan–Meier plot and Cox proportional hazards regression tests.
Results: Higher level of plasma 25(OH)D level in COVID-19 patients was independently associated with shorter nucleic acid
negative conversion time from COVID-19 infection (multivariate adjusted HR: 0.54, 95%CI: 0.35–0.82, P=0.004, tertile 2 vs 1;
multivariate adjusted HR: 0.60, 95%CI: 0.39–0.90, P=0.014, tertile 3 vs 1).
Conclusion: Plasma 25(OH)D level may serve as an independent prognostic factor in COVID-19 patient. Our findings indicate the
protective roles of vitamin D supplementation in the regiment of patients with COVID-19.
Keywords: SARS-CoV-2, COVID-19, plasma 25(OH)D level, nucleic acid negative conversion time
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