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0 0.5 1 1.5 2+ Viral clearance 40% Improvement Relative Risk c19early.org/d Chen et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 105 patients in China (June - July 2022) Improved viral clearance with higher vitamin D levels (p=0.014) Chen et al., Infection and Drug Resistance, doi:10.2147/idr.s400561 Favors vitamin D Favors control
Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
Chen et al., Infection and Drug Resistance, doi:10.2147/idr.s400561
Chen et al., Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An.., Infection and Drug Resistance, doi:10.2147/idr.s400561
Feb 2023   Source   PDF  
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Retrospective 158 COVID+ patients in China, showing low vitamin D levels associated with slower viral clearance.
viral clearance, 40.0% improved, HR 0.60, p = 0.01, high D levels (≥41.07ng/mL) 52, low D levels (<27.5ng/mL) 53, adjusted per study, tertile 3 vs. tertile 1, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 28 Feb 2023, retrospective, China, peer-reviewed, 9 authors, study period 1 June, 2022 - 5 July, 2022.
Contact: pzchen@me.com, guzhidongruijin@163.com.
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Abstract: Infection and Drug Resistance Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Infection and Drug Resistance For personal use only. Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study Changqiang Chen 1, *, Pu Li 1, *, Jiuming Chen 1, *, Chunxiao Liu 2 , Xiaodan Wang 3 , Jialin Cai 4 , Enfei Xiang 4 , Zhidong Gu 1,5 , Peizhan Chen 4 1 Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4 Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 5Department of Laboratory Medicine, Ruijin-Hainan Hospital, Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital), Hainan, People’s Republic of China 2 *These authors contributed equally to this work Correspondence: Peizhan Chen, Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201821, People’s Republic of China, Tel +86 13918550745, Email pzchen@me.com; Zhidong Gu, Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201821, People’s Republic of China, Tel +86 13801653534, Email guzhidongruijin@163.com Purpose: Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome for COVID-19 patients is unknown. Here, we aimed to determine the prognostic value of plasma 25(OH)D level in COVID-19 patients. Patients and Methods: A total of 158 patients infected with novel COVID-19 Omicron variants in Shanghai were recruited in this study and were categorized into three groups by the tertile levels of plasma 25(OH)D. Plasma 25(OH)D level was determined along with routine blood tests related to liver and renal functions in newly diagnosed COVID-19 patients at admission. The nucleic acid negative conversion time of throat swab samples was evaluated as the primary clinical outcome. The prognostic value of clinical characteristics and plasma 25(OH)D level was assessed using the Kaplan–Meier plot and Cox proportional hazards regression tests. Results: Higher level of plasma 25(OH)D level in COVID-19 patients was independently associated with shorter nucleic acid negative conversion time from COVID-19 infection (multivariate adjusted HR: 0.54, 95%CI: 0.35–0.82, P=0.004, tertile 2 vs 1; multivariate adjusted HR: 0.60, 95%CI: 0.39–0.90, P=0.014, tertile 3 vs 1). Conclusion: Plasma 25(OH)D level may serve as an independent prognostic factor in COVID-19 patient. Our findings indicate the protective roles of vitamin D supplementation in the regiment of patients with COVID-19. Keywords: SARS-CoV-2, COVID-19, plasma 25(OH)D level, nucleic acid negative conversion time
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