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0 0.5 1 1.5 2+ Viral clearance 40% Improvement Relative Risk Vitamin D for COVID-19  Chen et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 105 patients in China (June - July 2022) Improved viral clearance with higher vitamin D levels (p=0.014) Chen et al., Infection and Drug Resist.., Feb 2023 Favors vitamin D Favors control

Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study

Chen et al., Infection and Drug Resistance, doi:10.2147/idr.s400561
Feb 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 158 COVID+ patients in China, showing low vitamin D levels associated with slower viral clearance.
This is the 159th of 192 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 611 vigintillion).
viral clearance, 40.0% improved, HR 0.60, p = 0.01, high D levels (≥41.07ng/mL) 52, low D levels (<27.5ng/mL) 53, adjusted per study, tertile 3 vs. tertile 1, multivariable, Cox proportional hazards.
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Chen et al., 28 Feb 2023, retrospective, China, peer-reviewed, 9 authors, study period 1 June, 2022 - 5 July, 2022. Contact:,
This PaperVitamin DAll
Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
Changqiang Chen, Pu Li, Jiuming Chen, Chunxiao Liu, Xiaodan Wang, Jialin Cai, Enfei Xiang, Zhidong Gu, Peizhan Chen
Infection and Drug Resistance, doi:10.2147/idr.s400561
Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome for COVID-19 patients is unknown. Here, we aimed to determine the prognostic value of plasma 25(OH)D level in COVID-19 patients. Patients and Methods: A total of 158 patients infected with novel COVID-19 Omicron variants in Shanghai were recruited in this study and were categorized into three groups by the tertile levels of plasma 25(OH)D. Plasma 25(OH)D level was determined along with routine blood tests related to liver and renal functions in newly diagnosed COVID-19 patients at admission. The nucleic acid negative conversion time of throat swab samples was evaluated as the primary clinical outcome. The prognostic value of clinical characteristics and plasma 25(OH)D level was assessed using the Kaplan-Meier plot and Cox proportional hazards regression tests. Results: Higher level of plasma 25(OH)D level in COVID-19 patients was independently associated with shorter nucleic acid negative conversion time from COVID-19 infection (multivariate adjusted HR: 0.54, 95%CI: 0.35-0.82, P=0.004, tertile 2 vs 1; multivariate adjusted HR: 0.60, 95%CI: 0.39-0.90, P=0.014, tertile 3 vs 1). Conclusion: Plasma 25(OH)D level may serve as an independent prognostic factor in COVID-19 patient. Our findings indicate the protective roles of vitamin D supplementation in the regiment of patients with COVID-19.
Abbreviations vitD, plasma 25(OH)D level; WBC#, white blood cell count; RDW, red blood cell distribution width; RBC#, red blood cell count; PLT#, platelet count; NEUT%, neutrophil percentage; MPV, mean platelet volume; NEUT#, neutrophil count; MONO%, monocyte percentage; MONO#, monocyte count; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; LYMPH%, lymphocyte percentage; MCH, mean corpuscular hemoglobin; HGB, hemoglobin; LYMPH#, lymphocyte count; HCT, hematocrit; EO#, eosinophil count; EO%, eosinophil percentage; BASO%, basophil percentage; BASO#, basophil count; A/G, albumin-globulin ratio; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; UREA, urea; CREA, creatinine; DBIL, direct bilirubin; GGT, γ-glutamyl transpeptidase; TBIL, total bilirubin; TP, total protein; TBA, total biliary acid; UA, uric acid; PA, prealbumin; ADA, adenosine deaminase; eGFR, estimated glomerular filtration rate; CG, cholyglycine. Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Disclosure The authors..
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