Vitamin D levels associate with blood glucose and BMI in COVID-19 patients predicting disease severity
et al, The Journal of Clinical Endocrinology & Metabolism, doi:10.1210/clinem/dgab599
, Vitamin D levels associate with blood glucose and BMI in COVID-19 patients predicting disease severity, et al, The Journal of Clinical Endocrinology & Metabolism, doi:10.1210/clinem/dgab599
Retrospective 88 patients in Italy, showing vitamin D deficiency associated with severe cases, blood glucose, and BMI.This is the 88th of 177 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 26 vigintillion).
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risk of death, 10.7% lower, RR 0.89, p = 1.00, high D levels 5 of 28 (17.9%), low D levels 12 of 60 (20.0%), NNT 47, >20ng/mL.
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risk of ICU admission, 41.6% lower, RR 0.58, p = 0.22, high D levels 6 of 28 (21.4%), low D levels 22 of 60 (36.7%), NNT 6.6, >20ng/mL.
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risk of severe case, 39.6% lower, RR 0.60, p = 0.04, high D levels 11 of 28 (39.3%), low D levels 39 of 60 (65.0%), NNT 3.9, >20ng/mL.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
di Filippo et al., 12 Aug 2021, retrospective, Italy, peer-reviewed, 8 authors.
Vitamin D levels associate with blood glucose and BMI in COVID-19 patients predicting disease severity
doi:10.1210/clinem/dgab599/6349205
Context: High prevalence of Vitamin-D (VD) deficiency in COVID-19 patients was reported and hypothesized to increase COVID-19 severity likely due to its negative impact on immune and inflammatory responses. Furthermore, clear associations between hypovitaminosis-D and fat body-mass excess and diabetes, factors associated with COVID-19 severity, have been widely recognized. Objective: The aim of this study was to evaluate in COVID-19 patients the relationship between VD levels and inflammatory response, BMI, blood glucose and disease severity. Design: Patients admitted to San Raffaele-Hospital for COVID-19 were enrolled in this study, excluding those with comorbidities and therapies influencing VD-metabolism. 25(OH)VD levels, plasma glucose levels, BMI and inflammatory parameters were evaluated at admission.
Results: A total of 88 patients were included. Median VD level was 16.3 ng/mL and VDdeficiency was found in 68.2% of patients. VD-deficiency was found more frequently in male patients and in those affected by severe COVID-19. Regression analyses showed a positive correlation between VD and PaO2/FiO2 ratio, and negative correlations between VD and plasma glucose, BMI, Neutrophil/Lymphocyte ratio, CRP and IL-6.
References
Afzal, Bojesen, Nordestgaard, Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis, Clin Chem, doi:10.1373/clinchem.2012.193003
Akbar, Wibowo, Pranata, Setiabudiawan, Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis, Front Nutr, doi:10.3389/fnut.2021.660420
Bassatne, Basbous, Chakhtoura, Zein, Rahme et al., The link between COVID-19 and VItamin D (VIVID): a systematic review and meta-analysis
Biesalski, Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome, Curr Opin Clin Nutr Metab Care, doi:10.1097/MCO.0000000000000700
Bilezikian, Bikle, Hewison, MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19, Eur J Endocrinol, doi:10.1530/EJE-20-0665
Bischoff-Ferrari, Dietrich, Orav, Hughes, Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults, Am J Med, doi:10.1016/j.amjmed.2003.12.029
Bouillon, Marcocci, Carmeliet, Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions, Endocr Rev, doi:10.1210/er.2018-00126
Brandi, Giustina, Filippo, Frara, Giustina, Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality, doi:10.1016/j.tem.2020.09.00310
Burton, Fort, Seoane, Hospitalization and Mortality among Black Patients and White Patients with Covid-19, N Engl J Med, doi:10.1056/NEJMsa2011686
Carpagnano, Lecce, Quaranta, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
Cereda, Bogliolo, Klersy, Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital
Chen, Chu, Doebis, Baehr, Hocher, Sex Dependent Association of Vitamin D with Insulin Resistance
Ciceri, Castagna, Rovere-Querini, Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy, Clin Immunol, doi:10.1016/j.clim.2020.108509
Coppelli, Giannarelli, Aragona, Hyperglycemia at Hospital Admission Is Associated With Severity of the Prognosis in Patients Hospitalized for COVID-19: The Pisa COVID-19 Study, Diabetes Care, doi:10.2337/dc20-1380
D'avolio, Avataneo, Manca, 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2, Nutrients, doi:10.3390/nu12051359
Di Filippo, Doga, Frara, Giustina, Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications
Di Filippo, Formenti, Doga, Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients, Endocrine, doi:10.1007/s12020-020-02541-9
Di Filippo, Formenti, Doga, Pedone, Rovere-Querini et al., Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes, J Clin Endocrinol Metab, doi:10.1210/clinem/dgaa738
Di Filippo, Formenti, Giustina, Hypocalcemia: the quest for the cause of a major biochemical feature of COVID-19, Endocrine, doi:10.1007/s12020-020-02525-9
Diabetes, Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020, Diabetes Care, doi:10.2337/dc20-S002
Ding, Gao, Wilding, Trayhurn, Bing, Vitamin D signalling in adipose tissue, Br J Nutr, doi:10.1017/S0007114512003285
Dossari, Ahmad, Aljowair, Association of vitamin d with glycemic control in Saudi patients with type 2 diabetes: a retrospective chart review study in an emerging university hospital, J. Clin. Lab. Anal, doi:10.1002/jcla.23048
Favre, Legueult, Pradier, Raffaelli, Ichai et al., Visceral fat is associated to the severity of COVID-19, Metabolism, doi:10.1016/j.metabol.2020.154440
Ferrari, Locatelli, Briguglio, Lombardi, Is there a link between vitamin D status, SARS-CoV-2 infection risk and COVID-19 severity?, Cell Biochem Funct, doi:10.1002/cbf.3597
Filippo, Formenti, Rovere-Querini, Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19, Endocrine, doi:10.1007/s12020-020-02383-5
Filippo, Lorenzo, Cinel, Weight trajectories and abdominal adiposity in COVID-19 survivors with overweight/obesity
Formenti, Tecilazich, Frara, Giubbini, Luca et al., Body mass index predicts resistance to active vitamin D in patients with hypoparathyroidism, Endocrine, doi:10.1007/s12020-019-02105-6
Formenti, Volta, Di Filippo, Berruti, Giustina, Effects of Medical Treatment of Prostate Cancer on Bone Health, Trends Endocrinol Metab, doi:10.1016/j.tem.2020.12.004
Gerstein, Miller, Action to Control Cardiovascular Risk in Diabetes Study Group, N Engl J Med, doi:10.1056/NEJMoa0802743
Giustina, Adler, Binkley, Consensus statement from 2nd International Conference on Controversies in Vitamin D, Rev Endocr Metab Disord, doi:10.1007/s11154-019-09532-w
Giustina, Bouillon, Binkley, Controversies in Vitamin D: A Statement From the Third International Conference, JBMR Plus, doi:10.1002/jbm4.10417
Giustina, Formenti, Preventing a covid-19 pandemic Can high prevalence of severe hypovitaminosis D play a role in the high impact of Covid infection in Italy?, BMJ
Giustina, Hypovitaminosis D and the endocrine phenotype of COVID-19
Gupta, Madhavan, Sehgal, Extrapulmonary manifestations of COVID
Hernández, Nan, Fernandez-Ayala, Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection
Hough, Sonn, Birge, Avioli, Vitamin D metabolism in the chronic streptozotocin-induced diabetic rats, Endocrinology, doi:10.1210/endo-113-2-790
Hu, Chen, Sun, Wang, Wang, Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients: A meta-analysis of interventional studies, Medicine, doi:10.1097/MD.0000000000014970
Hussain, Mahawar, Xia, Yang, El-Hasani, Obesity and mortality of COVID-19. Meta analysis [published correction appears, Obes Res Clin Pract
Hutchings, Babalyan, Baghdasaryan, Patients hospitalized with COVID-19 have low levels of 25-hydroxyvitamin D, Endocrine, doi:10.1007/s12020-020-02597-7
Isaia, Giorgino, Adami, High prevalence of hypovitaminosis D in female type 2 diabetic population, Diabetes Care, doi:10.2337/diacare.24.8.1496
Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci Rep, doi:10.1038/s41598-020-77093-z
Jolliffe, Camargo, Jr, Sluyter, Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Kazemi, Mohammadi, Aghababaee, Golzarand, Clark et al., Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis
Krul-Poel, Wee, Lips, Simsek, Management et al., DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis, Eur J Endocrinol, doi:10.1530/EJE-16-0391
Li, Guan, Wu, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia, N Engl J Med, doi:10.1056/NEJMoa2001316
Li, Liu, Mao, Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis
Lima-Martínez, Boada, Madera-Silva, Marín, Contreras, COVID-19 and diabetes: A bidirectional relationship, Clin Investig Arterioscler, doi:10.1016/j.arteri.2020.10.001
Maddaloni, Cavallari, Napoli, Conte, Vitamin D and Diabetes Mellitus, Front Horm Res, doi:10.1159/000486083
Mancini, Mazziotti, Doga, Vertebral fractures in males with type 2 diabetes treated with rosiglitazone, Bone, doi:10.1016/j.bone.2009.06.006
Manson, A Cluster-Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Vitamin D3 Supplementation to Reduce Disease Severity in Persons With Newly Diagnosed COVID-19
Marazuela, Giustina, Puig-Domingo, Endocrine and metabolic aspects of the COVID-19 pandemic [published correction appears, Rev Endocr Metab Disord
Mariani, Tajer, Antonietti, Inserra, Ferder et al., High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL), Trials, doi:10.1186/s13063-021-05073-3
Martins, Boavida, Raposo, Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients, BMJ Open Diabetes Res Care, doi:10.1136/bmjdrc-2015-000181
Mazziotti, Bilezikian, Canalis, Cocchi, Giustina, New understanding and treatments for osteoporosis, Endocrine, doi:10.1007/s12020-011-9570-2
Mehta, Mcauley, Brown, COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet, doi:10.1016/S0140-6736(20)30628-0
Migliaccio, Nisio, Mele, Obesity and hypovitaminosis D: causality or casualty?, Int J Obes Suppl, doi:10.1038/s41367-019-0010-8
Monteverdi, Pedersini, Gallo, The Interaction of Lean Body Mass With Fat Body Mass Is Associated With Vertebral Fracture Prevalence in Women With Early Breast Cancer Undergoing Aromatase Inhibitor Therapy, JBMR Plus
Pereira-Santos, Costa, Assis, Santos, Santos, Obesity and vitamin D deficiency: a systematic review and meta-analysis, Obes Rev, doi:10.1111/obr.12239
Pietschmann, Schernthaner, Woloszczuk, Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications, Diabetologia, doi:10.1007/BF00265373
Pittas, Hughes, Sheehan, Vitamin D Supplementation and Prevention of Type 2 Diabetes, N Engl J Med, doi:10.1056/NEJMoa1900906
Pizzini, Aichner, Sahanic, Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry, Nutrients, doi:10.3390/nu12092775
Ponti, Maccaferri, Ruini, Tomasi, Ozben, Biomarkers associated with COVID-19 disease progression, Crit Rev Clin Lab Sci, doi:10.1080/10408363.2020.1770685
Pramono, Jocken, Essers, Goossens, Blaak, Vitamin D and Tissue-Specific Insulin Sensitivity in Humans With Overweight/Obesity, J Clin Endocrinol Metab, doi:10.1210/jc.2018-00995
Puig-Domingo, Marazuela, Giustina, COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology, Endocrine, doi:10.1007/s12020-020-02294-5
Richardson, Hirsch, Narasimhan, Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area [published correction appears, JAMA
Rousseau, Vitamin D Supplementation and Covid-19: a Randomised, Double-Blind, Controlled Study
Rovere-Querini, Tresoldi, Conte, Biobanking for COVID-19 research
Sempos, Heijboer, Bikle, Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D, Br J Clin Pharmacol, doi:10.1111/bcp.13652
Smet, Smet, Herroelen, Gryspeerdt, Martens, Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality, Am J Clin Pathol, doi:10.1093/ajcp/aqaa252
Tecilazich, Formenti, Giustina, Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects
Tsuprykov, Buse, Skoblo, Haq, Hocher, Reference intervals for measured and calculated free 25-hydroxyvitamin D in normal pregnancy, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2018.03.005
Tsur, Feldman, Feldhammer, Hoshen, Leibowitz et al., Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes, Diabetes Care, doi:10.2337/dc12-1050
Wang, Hu, Hu, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published correction appears, JAMA
Zeng, Chu, Doebis, Baehr, Hocher, Reference values for free 25-hydroxy-vitamin D based on established total 25-hydroxy-vitamin D reference values, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2021.105877
Zhou, Chi, Lv, Wang, Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19), Diabetes Metab Res Rev, doi:10.1002/dmrr.3377
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