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0 0.5 1 1.5 2+ Mortality 51% Improvement Relative Risk Mortality, continuous values 3% Vitamin D  Cetin Ozbek et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 168 patients in Turkey (August - October 2021) Lower mortality with higher vitamin D levels (not stat. sig., p=0.068) Cetin Ozbek et al., Clinical Science o.., Mar 2023 Favors vitamin D Favors control

Does the Level of Vitamin D in COVID-19 Patients Affect the Survival and Duration of Hospital Stay?

Cetin Ozbek et al., Clinical Science of Nutrition, doi:10.5152/ClinSciNutr.2023.22059
Mar 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 168 hospitalized COVID-19 patients, showing no significant association between vitamin D levels and mortality. Adjusted results are only provided for vitamin D as a continuous variable.
This is the 169th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 50.9% lower, RR 0.49, p = 0.07, high D levels (≥20ng/mL) 7 of 61 (11.5%), low D levels (<20ng/mL) 25 of 107 (23.4%), NNT 8.4.
risk of death, 3.0% lower, OR 0.97, p = 0.32, adjusted per study, continuous values, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cetin Ozbek et al., 24 Mar 2023, retrospective, Turkey, peer-reviewed, mean age 63.4, 6 authors, study period 1 August, 2021 - 31 October, 2021. Contact:
This PaperVitamin DAll
Does the Level of Vitamin D in COVID-19 Patients Affect the Survival and Duration of Hospital Stay?
Sevan Cetin Ozbek, Selen Ozsoy, Levent Ozturk
Clinical Science of Nutrition, doi:10.5152/clinscinutr.2023.22059
Objective: This study aimed to evaluate the effect of categorized and normal vitamin D levels on hospital stay and mortality in adult patients with COVID-19. Methods: One hundred sixty-eight hospitalized patients due to coronavirus disease 2019 were retrospectively evaluated. The study data were collected from medical records (age, gender, comorbidity, vitamin D level, duration of hospital stay, mortality/ survival status). Serum 25(OH) vitamin D level ≥ 30 ng/mL is defined as normal, 20-29 ng/mL is an insufficiency level, and less than 20 ng/mL is defined as a deficiency level. Results: The mean vitamin D level of 168 patients was 18.72 ± 11.18 ng/mL, and 79.4% of patients with vitamin D deficiency had comorbidity. When vitamin D levels were categorized, there was no difference between the groups regarding hospital stay and survival (P > .05). However, when the mean vitamin D levels between the deceased and surviving patients were assessed, vitamin D levels were significantly higher in the survivors (P = .019). Vitamin D significantly affected survival compared to the univariate model (P = .044), while there was no significant effect on the multivariate model (P > .05). Even when the factors affecting the vitamin D level were adjusted, no significant results were found. Conclusion: Among hospitalized COVID-19 patients, vitamin D levels did not support an association between the duration of hospital stay and mortality.
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Crf, chronic renal failure; CVD, cardiovascular diseases; DM, diabetes mellitus
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