Does the Level of Vitamin D in COVID-19 Patients Affect the Survival and Duration of Hospital Stay?
Sevan Cetin Ozbek, Selen Ozsoy, Levent Ozturk
Clinical Science of Nutrition, doi:10.5152/clinscinutr.2023.22059
Objective: This study aimed to evaluate the effect of categorized and normal vitamin D levels on hospital stay and mortality in adult patients with COVID-19. Methods: One hundred sixty-eight hospitalized patients due to coronavirus disease 2019 were retrospectively evaluated. The study data were collected from medical records (age, gender, comorbidity, vitamin D level, duration of hospital stay, mortality/ survival status). Serum 25(OH) vitamin D level ≥ 30 ng/mL is defined as normal, 20-29 ng/mL is an insufficiency level, and less than 20 ng/mL is defined as a deficiency level.
Results: The mean vitamin D level of 168 patients was 18.72 ± 11.18 ng/mL, and 79.4% of patients with vitamin D deficiency had comorbidity. When vitamin D levels were categorized, there was no difference between the groups regarding hospital stay and survival (P > .05). However, when the mean vitamin D levels between the deceased and surviving patients were assessed, vitamin D levels were significantly higher in the survivors (P = .019). Vitamin D significantly affected survival compared to the univariate model (P = .044), while there was no significant effect on the multivariate model (P > .05). Even when the factors affecting the vitamin D level were adjusted, no significant results were found. Conclusion: Among hospitalized COVID-19 patients, vitamin D levels did not support an association between the duration of hospital stay and mortality.
References
Alkhafaji, Argan, Albaker, The impact of vitamin D level on the severity and outcome of hospitalized patients with COVID-19 disease, Int J Gen Med,
doi:10.2147/IJGM.S346169Alpdemir, Alpdemir, Vitamin D deficiency status in Turkey: a meta-analysis, Int J Biochem
Antos, Kwong, Balmorez, Villanueva, Murakami, Unusually high risks of COVID-19 mortality with age-related comorbidities: an adjusted meta-analysis method to improve the risk assessment of mortality using the comorbid mortality data, Infect Dis Rep,
doi:10.3390/idr13030065Brenner, Vitamin D supplementation to prevent COVID-19 infections and deaths-accumulating evidence from epidemiological and intervention studies calls for immediate action, Nutrients,
doi:10.3390/nu13020411Campi, Gennari, Merlotti, Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy, BMC Infect Dis,
doi:10.1186/s12879-021-06281-7Chen, Mei, Xie, Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs, Nutr J,
doi:10.1186/s12937-021-00744-yCrf, chronic renal failure; CVD, cardiovascular diseases; DM, diabetes mellitus
Demir, Demir, Aygun, Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease, J Med Virol,
doi:10.1002/jmv.26832Grant, Holick, Benefits and requirements of vitamin D for optimal health: a review, Altern Med Rev
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients,
doi:10.3390/nu12040988Holick, The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention, Rev Endocr Metab Disord,
doi:10.1007/s11154-017-9424-1Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID 19 patients and its correlation with inflammatory markers, Sci Rep,
doi:10.1038/s41598-020-77093-zKarahan, Katkat, Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey, J Nutr Health Aging,
doi:10.1007/s12603-020-1479-0Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS One
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Netw Open,
doi:10.1001/jamanetworkopen.2020.19722Mitchell, Vitamin-D and COVID-19: do deficient risk a poorer outcome?, Lancet Diabetes Endocrinol
Muscogiuri, Vitamin D: past, present and future perspectives in the prevention of chronic diseases, Eur J Clin Nutr,
doi:10.1038/s41430-018-0261-4Pal, Banerjee, Bhadada, Shetty, Singh et al., Vitamin D supplementation and clinical outcomes in COVID 19: a systematic review and meta-analysis, J Endocrinol Invest,
doi:10.1007/s40618-021-01614-4Pecina, Merry, Park, Td, Vitamin D status and severe COVID-19 disease outcomes in hospitalized patients, J Prim Care Community Health,
doi:10.1177/21501327211041206Pilz, Zittermann, Trummer, Vitamin D testing and treatment: a narrative review of current evidence, Endocr Connect,
doi:10.1530/EC-18-0432Rashedi, Poor, Asgharzadeh, Risk factors for COVID-19, Infez Med
Reis, Fernandes, Sales, Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study, Am J Clin Nutr,
doi:10.1093/ajcn/nqab151Serdar, Can, Kilercik, Analysis of changes in parathyroid hormone and 25 (OH) vitamin D levels with respect to age, gender and season: a data mining study, J Med Biochem,
doi:10.1515/jomb-2017-0002Siddiqui, Manansala, Abdulrahman, Immune modulatory effects of vitamin D on viral infections, Nutrients,
doi:10.3390/nu12092879Taha, Abureesh, Alghamdi, The relationship between vitamin D and infections including COVID-19: any hopes?, Int J Gen Med,
doi:10.2147/IJGM.S317421Teshome, Adane, Girma, Mekonnen, The impact of vitamin D level on COVID-19 infection: systematic review and meta-analysis, Front Public Health
Teymoori-Rad, Marashi, Vitamin D and Covid-19: from potential therapeutic effects to unanswered questions, Rev Med Virol,
doi:10.1002/rmv.2159Yeşiltepe-Mutlu, Aksu, Bereket, Hatun, Vitamin D status across age groups in Turkey: results of 108,742 samples from a single laboratory, J Clin Res Pediatr Endocrinol,
doi:10.4274/jcrpe.galenos.2019.2019.0097
