Abstract: Journal Pre-proof Efficacy of remdesivir in hospitalized nonsevere COVID-19 patients in Japan: A large observational study using the COVID-19 Registry Japan Shinya Tsuzuki , Kayoko Hayakawa , Yukari Uemura , Tomohiro Shinozaki , Nobuaki Matsunaga , Mari Terada , Setsuko Suzuki , Yusuke Asai , Koji Kitajima , Sho Saito , Gen Yamada , Taro Shibata , Masashi Kondo , Kazuo Izumi , Masayuki Hojo , Tetsuya Mizoue , Kazuhisa Yokota , Fukumi Nakamura-Uchiyama , Fumitake Saito , Wataru Sugiura , Norio Ohmagari PII: DOI: Reference: S1201-9712(22)00118-7 https://doi.org/10.1016/j.ijid.2022.02.039 IJID 6030 To appear in: International Journal of Infectious Diseases Received date: Revised date: Accepted date: 17 January 2022 15 February 2022 17 February 2022 Please cite this article as: Shinya Tsuzuki , Kayoko Hayakawa , Yukari Uemura , Tomohiro Shinozaki , Nobuaki Matsunaga , Mari Terada , Setsuko Suzuki , Yusuke Asai , Koji Kitajima , Sho Saito , Gen Yamada , Taro Shibata , Masashi Kondo , Kazuo Izumi , Masayuki Hojo , Tetsuya Mizoue , Kazuhisa Yokota , Fukumi Nakamura-Uchiyama , Fumitake Saito , Wataru Sugiura , Norio Ohmagari , Efficacy of remdesivir in hospitalized nonsevere COVID-19 patients in Japan: A large observational study using the COVID-19 Registry Japan, International Journal of Infectious Diseases (2022), doi: https://doi.org/10.1016/j.ijid.2022.02.039 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Efficacy of remdesivir in hospitalized nonsevere COVID-19 patients in Japan: A large observational study using the COVID-19 Registry Japan Shinya Tsuzukia,b,*, Kayoko Hayakawaa,c, Yukari Uemurad, Tomohiro Shinozakie, Nobuaki Matsunagaa, Mari Teradac,d, Setsuko Suzukic, Yusuke Asaia, Koji Kitajimad, Sho Saitoc, Gen Yamadac, Taro Shibataf, Masashi Kondog, Kazuo Izumid, Masayuki Hojoh, Tetsuya Mizouei, Kazuhisa Yokotaj, Fukumi Nakamura-Uchiyamak, Fumitake Saitol, Wataru Sugiurad, Norio Ohmagaria,c a AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan b c Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan d Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan e Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan f Biostatistics Division, Center for Research Administration and Support, National Cancer Center, Tokyo, Japan 1 g Center for Clinical Trial and Research Support, Fujita Health University, Aichi, Japan h Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan i Department of..