Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry Japan
Shinya Tsuzuki, Kayoko Hayakawa, Yukari Uemura, Tomohiro Shinozaki, Nobuaki Matsunaga, Mari Terada, Setsuko Suzuki, Yusuke Asai, Koji Kitajima, Sho Saito, Gen Yamada, Taro Shibata, Masashi Kondo, Kazuo Izumi, Masayuki Hojo, Tetsuya Mizoue, Kazuhisa Yokota, Fukumi Nakamura-Uchiyama, Fumitake Saito, Wataru Sugiura, Norio Ohmagari
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.02.039
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Ethics This study was approved by the NCGM ethics review (NCGM-G-003494-0). Information regarding opting out of our study is available on the registry website.
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:
References
Cevik, Kuppalli, Kindrachuk, Peiris, Virology, transmission, and pathogenesis of SARS-CoV-2, BMJ,
doi:10.1136/bmj.m3862
Commissioner, The, Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment
Core, R: A language and environment for statistical computing
Cunningham, Vaduganathan, Claggett, Jering, Bhatt et al., Clinical outcomes in young US adults hospitalized with COVID-19, JAMA Intern Med,
doi:10.1001/jamainternmed.2020.5313
Hernán, How to estimate the effect of treatment duration on survival outcomes using observational data, BMJ,
doi:10.1136/bmj.k182
Hernán, Sauer, Hernández-Díaz, Platt, Shrier, Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses,
doi:10.1016/j.jclinepi.2016.04.014
Lighter, Phillips, Hochman, Sterling, Johnson et al., Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission, Clin Infect Dis,
doi:10.1093/cid/ciaa415
Matsunaga, Hayakawa, Terada, Ohtsu, Asai et al., Clinical epidemiology of hospitalized patients with COVID-19 in Japan: report of the COVID-19 REGISTRY JAPAN, Clin Infect Dis,
doi:10.1093/cid/ciaa1470.MinistryofHealth
Pan, Peto, Henao-Restrepo, Preziosi, Sathiyamoorthy, Repurposed antiviral drugs for COVID-19 -Interim WHO solidarity trial results, N Engl J Med,
doi:10.1056/NEJMoa2023184
Robins Finkelstein, Correcting for noncompliance and dependent censoring in an AIDS clinical trial with inverse probability of censoring weighted (IPCW) log-rank tests, Biometrics,
doi:10.1111/j.0006-341X.2000.00779.x
Rosenbaum, Db, The central role of the propensity score in observational studies for causal effects, Biometrika
Saito, Hayakawa, Mikami, Izumi, Funazaki et al., Investigator initiated clinical trial of remdesivir for the treatment of COVID-19 in Japan, GHM,
doi:10.35772/ghm.2020.01106
Spinner, Gottlieb, Criner, López, Cattelan et al., Effect of remdesivir vs standard care on clinical status at 11 days in patients with moderate COVID-19: a randomized clinical trial, JAMA,
doi:10.1001/jama.2020.16349
Suissa, Dell'aniello, Time-related biases in pharmacoepidemiology, Pharmacoepidemiol Drug Saf,
doi:10.1002/pds.5083
Tartof, Qian, Hong, Wei, Nadjafi et al., Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization, Ann Intern Med,
doi:10.7326/M20-3742
Williamson, Walker, Bhaskaran, Bacon, Bates et al., Factors associated with COVID-19-related death using OpenSAFELY, Nature,
doi:10.1038/s41586-020-2521-4
Yeming, Zhang, Du, Du, Zhao et al., Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, Lancet,
doi:10.1016/S0140-6736(20)31022-9
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