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All Studies   Meta Analysis    Recent:   

Hospital Outcomes in Patients Hospitalized for COVID-19 Pneumonia: The Effect of SARS-CoV-2 Vaccination and Vitamin D Status

Sanecka et al., Nutrients, doi:10.3390/nu15132976
Jun 2023  
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Mortality 95% Improvement Relative Risk ICU admission 81% Vitamin D for COVID-19  Sanecka et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 171 patients in Ireland (Jun - Dec 2021) Lower mortality (p=0.029) and ICU admission (p=0.05) c19early.org Sanecka et al., Nutrients, June 2023 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Prospective study of 171 hospitalized COVID-19 patients in Ireland, showing significantly lower mortality and ICU admission with sufficient vitamin D levels among unvaccinated patients. There were no significant differences for vaccinated patients. Authors note that high vitamin D levels or recent vaccination were associated with lower mortality. Adjusted results are only reported for unvaccinated patients and mortality/ICU admission, where results were significant. More vaccinated patients had sufficient vitamin D levels despite the group being older (mean age 69 vs. 46). There may be a link based on health conscientiousness between vaccination, vitamin D supplementation, and other measures and lifestyle factors that reduce risk.
risk of death, 94.9% lower, RR 0.05, p = 0.03, high D levels (≥50nmol/L) 1 of 39 (2.6%), low D levels (<30nmol/L) 4 of 18 (22.2%), NNT 5.1, adjusted per study, inverted to make RR<1 favor high D levels (≥50nmol/L), odds ratio converted to relative risk, unvaccinated patients, multivariable.
risk of ICU admission, 80.9% lower, RR 0.19, p = 0.05, high D levels (≥50nmol/L) 3 of 39 (7.7%), low D levels (<30nmol/L) 5 of 18 (27.8%), NNT 5.0, adjusted per study, inverted to make RR<1 favor high D levels (≥50nmol/L), odds ratio converted to relative risk, unvaccinated patients, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sanecka et al., 30 Jun 2023, prospective, Ireland, peer-reviewed, 16 authors, study period June 2021 - December 2021. Contact: johnfaul@rsci.ie (corresponding author), martynasanecka@gmail.com, daniel.mccartney@tudublin.ie.
This PaperVitamin DAll
Hospital Outcomes in Patients Hospitalized for COVID-19 Pneumonia: The Effect of SARS-CoV-2 Vaccination and Vitamin D Status
Martyna Sanecka, Modar Youssef, Mohammad Abdulsalam, Syed F Raza, Abdul Qadeer, Julia Ioana, Alya Aldoresi, Syed I Shah, Abdul Al Lawati, Joseph Feely, William P Tormey, Eoghan O’neill, Liam J Cormican, Eoin P Judge, Daniel M A Mccartney, John L Faul
Nutrients, doi:10.3390/nu15132976
SARS-CoV-2 vaccination promises to improve outcomes for patients with COVID-19 pneumonia (most notably those with advanced age and at high risk for severe disease). Here, we examine serum 25-Hydroxyvitamin D (25(OH)D) status and outcomes in both old (>70 years) and young vaccinated (n = 80) and unvaccinated (n = 91) subjects, who were hospitalized due to COVID-19 pneumonia in a single center (Connolly Hospital Dublin). Outcomes included ICU admission and mortality. Serum 25(OH)D levels were categorized as D30 (<30 nmol/L), D40 (30-49.99 nmol/L) and D50 (≥50 nmol/L). In multivariate analyses, D30 was independently associated with ICU admission (OR: 6.87 (95% CI: 1.13-41.85) (p = 0.036)) and mortality (OR: 24.81 (95% CI: 1.57-392.1) (p = 0.023)) in unvaccinated patients, even after adjustment for major confounders including age, sex, obesity and pre-existing diabetes mellitus. While mortality was consistently higher in all categories of patients over 70 years of age, the highest observed mortality rate of 50%, seen in patients over 70 years with a low vitamin D state (D30), appeared to be almost completely corrected by either vaccination, or having a higher vitamin D state, i.e., mortality was 14% for vaccinated patients over 70 years with D30 and 16% for unvaccinated patients over 70 years with a 25(OH)D level greater than 30 nmol/L. We observe that high mortality from COVID-19 pneumonia occurs in older patients, especially those who are unvaccinated or have a low vitamin D state. Recent vaccination or having a high vitamin D status are both associated with reduced mortality, although these effects do not fully mitigate the mortality risk associated with advanced age.
Author Contributions: M.S., data processing, data analysis, data interpretation, manuscript drafts; J.L.F. and D.M.A.M., study design, data interpretation, manuscript drafts, data analysis; M.Y., M.A., S.F.R., A.Q., J.I., A.A., S.I.S., J.F., W.P.T., E.O., L.J.C., E.P.J. and A.A.L. data collection, processing, analysis and interpretation; J.L.F., study design, data collection, processing, analysis and interpretation, manuscript drafts. All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Connolly Hospital Dublin. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflict of interest.
References
Andrews, Stowe, Kirsebom, Toffa, Rickeard et al., COVID-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant, N. Engl. J. Med, doi:10.1056/NEJMoa2119451
Angelidi, Belanger, Lorinsky, Karamanis, Chamorro-Pareja et al., Vitamin D Status Is Associated with In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients, Mayo Clin. Proc, doi:10.1016/j.mayocp.2021.01.001
Aranow, Vitamin D and the immune system, J. Investig. Med, doi:10.2310/JIM.0b013e31821b8755
Argano, Mallaci Bocchio, Natoli, Scibetta, Lo Monaco et al., Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis, Pharmaceuticals, doi:10.3390/ph16010130
Barrett, Youssef, Shah, Ioana, Lawati et al., Vitamin D Status and Mortality from SARS CoV-2: A Prospective Study of Unvaccinated Caucasian Adults, Nutrients, doi:10.3390/nu14163252
Bilezikian, Bikle, Hewison, Lazaretti-Castro, Formenti et al., Mechanisms In Endocrinology: Vitamin D and COVID-19, doi:10.1530/EJE-20-0665
Borsche, Glauner, Von Mendel, COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu13103596
Cashman, Dowling, Škrabáková, Gonzalez-Gross, Valtueña et al., Vitamin D deficiency in Europe: Pandemic?, Am. J. Clin. Nutr, doi:10.3945/ajcn.115.120873
Chauss, Freiwald, Mcgregor, Yan, Wang et al., Autocrine vitamin D signaling switches off pro-inflammatory programs of T H 1 cells, Nat. Immunol, doi:10.1038/s41590-021-01080-3
Chen, Mei, Xie, Yuan, Ma et al., Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: A meta-analysis and GRADE assessment of cohort studies and RCTs, Nutr. J, doi:10.1186/s12937-021-00744-y
Chiodini, Gatti, Soranna, Merlotti, Mingiano et al., Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes, Front. Public Health, doi:10.3389/fpubh.2021.736665
Chiu, Tsai, Wu, Zheng, Yang et al., Putative Role of Vitamin D for COVID-19 Vaccination, Int. J. Mol. Sci, doi:10.3390/ijms22168988
D'ecclesiis, Gavioli, Martinoli, Raimondi, Chiocca et al., Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis, PLoS ONE, doi:10.1371/journal.pone.0268396
Dror, Morozov, Daoud, Namir, Yakir et al., Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness, PLoS ONE, doi:10.1371/journal.pone.0263069
Griffin, Haddix, Danza, Fisher, Koo et al., SARS-CoV-2 Infections and Hospitalizations among Persons Aged ≥16 Years, by Vaccination Status, Morb. Mortal. Wkly. Rep, doi:10.15585/mmwr.mm7034e5
Hall, Foulkes, Insalata, Kirwan, Saei et al., Protection against SARS-CoV-2 after COVID-19 Vaccination and Previous Infection, N. Engl. J. Med, doi:10.1056/NEJMoa2118691
Hanna, Dalvi, Sălăgean, Pop, Bordea et al., Understanding COVID-19 Pandemic: Molecular Mechanisms and Potential Therapeutic Strategies. An Evidence-Based Review, J. Inflamm. Res, doi:10.2147/JIR.S282213
Hariyanto, Intan, Hananto, Harapan, Kurniawan, Vitamin D supplementation and COVID-19 outcomes: A systematic review, meta-analysis and meta-regression, Rev. Med. Virol, doi:10.1002/rmv.2269
Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci. Rep, doi:10.1038/s41598-020-77093-z
Jeong, Vacanti, Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, Nutr. Metab, doi:10.1186/s12986-020-00491-7
Jolliffe, Vivaldi, Chambers, Cai, Li et al., Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial, Nutrients, doi:10.3390/nu14183821
Lamacchia, Mazzoni, Spinicci, Vanni, Salvati et al., Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization, J. Clin. Immunol. 2022, doi:10.1007/s10875-022-01325-2
Lustig, Sapir, Regev-Yochay, Cohen, Fluss et al., COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers, Lancet Respir. Med, doi:10.1016/S2213-2600(21)00220-4
Mccartney, O'shea, Healy, Walsh, Griffin et al., The Causal Role of Vitamin D Deficiency in Worse COVID-19 Outcomes: Implications for Policy and Practice Development, Ir. Med. J
Pal, Banerjee, Bhadada, Shetty, Singh et al., Vitamin D supplementation and clinical outcomes in COVID-19: A systematic review and meta-analysis, J. Endocrinol. Investig, doi:10.1007/s40618-021-01614-4
Piec, Cook, Dervisevic, Fraser, Ruetten et al., Age and vitamin D affect the magnitude of the antibody response to the first dose of the SARS-CoV-2 BNT162b2 vaccine, Curr. Res. Transl. Med, doi:10.1016/j.retram.2022.103344
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger et al., Vitamin D Deficiency and Outcome of COVID-19 Patients, Nutrients, doi:10.3390/nu12092757
Shah, Varna, Sharma, Mavalankar, Does vitamin D supplementation reduce COVID-19 severity? a systematic review, QJM, doi:10.1093/qjmed/hcac040
Walsh, Mccartney, Laird, Mccarroll, Byrne et al., Understanding a Low Vitamin D State in the Context of COVID-19, Front. Pharmacol, doi:10.3389/fphar.2022.835480
Wolff, Nee, Hickey, Marschollek, Risk factors for COVID-19 severity and fatality: A structured literature review, Infection, doi:10.1007/s15010-020-01509-1
Zdrenghea, Makrinioti, Bagacean, Bush, Johnston et al., Vitamin D modulation of innate immune responses to respiratory viral infections, Rev. Med. Virol, doi:10.1002/rmv.1909
Zelini, Angelo, Cereda, Klersy, Sabrina et al., Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2, Biomedicines, doi:10.3390/biomedicines10081993
Zhou, Zhu, Chu, Role of COVID-19 Vaccines in SARS-CoV-2 Variants, Front. Immunol, doi:10.3389/fimmu.2022.898192
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Engl. J. Med.'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '1532', 'DOI': '10.1056/NEJMoa2119451', 'article-title': 'COVID-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant', 'volume': '386', 'author': 'Andrews', 'year': '2022', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'first-page': '898192', 'DOI': '10.3389/fimmu.2022.898192', 'article-title': 'Role of COVID-19 Vaccines in SARS-CoV-2 Variants', 'volume': '13', 'author': 'Zhou', 'year': '2022', 'journal-title': 'Front. Immunol.'}, { 'key': 'ref_4', 'doi-asserted-by': 'crossref', 'unstructured': 'Chiu, S.K., Tsai, K.W., Wu, C.C., Zheng, C.M., Yang, C.H., Hu, W.C., ' 'Hou, Y.C., Lu, K.C., and Chao, Y.C. (2021). Putative Role of Vitamin D ' 'for COVID-19 Vaccination. Int. J. Mol. Sci., 22.', 'DOI': '10.3390/ijms22168988'}, { 'key': 'ref_5', 'doi-asserted-by': 'crossref', 'unstructured': 'Jolliffe, D.A., Vivaldi, G., Chambers, E.S., Cai, W., Li, W., Faustini, ' 'S.E., Gibbons, J.M., Pade, C., Coussens, A.K., and Richter, A.G. (2022). ' 'Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy ' 'or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised ' 'Controlled Trial. Nutrients, 14.', 'DOI': '10.3390/nu14183821'}, { 'key': 'ref_6', 'doi-asserted-by': 'crossref', 'unstructured': 'Zelini, P., d’Angelo, P., Cereda, E., Klersy, C., Sabrina, P., ' 'Albertini, R., Grugnetti, G., Grugnetti, A.M., Marena, C., and Cutti, S. ' '(2022). Association between Vitamin D Serum Levels and Immune Response ' 'to the BNT162b2 Vaccine for SARS-CoV-2. Biomedicines, 10.', 'DOI': '10.3390/biomedicines10081993'}, { 'key': 'ref_7', 'doi-asserted-by': 'crossref', 'first-page': '103344', 'DOI': '10.1016/j.retram.2022.103344', 'article-title': 'Age and vitamin D affect the magnitude of the antibody response to the ' 'first dose of the SARS-CoV-2 BNT162b2 vaccine', 'volume': '70', 'author': 'Piec', 'year': '2022', 'journal-title': 'Curr. Res. Transl. Med.'}, { 'key': 'ref_8', 'doi-asserted-by': 'crossref', 'first-page': '999', 'DOI': '10.1016/S2213-2600(21)00220-4', 'article-title': 'BNT162b2 COVID-19 vaccine and correlates of humoral immune responses ' 'and dynamics: A prospective, single-centre, longitudinal cohort study ' 'in health-care workers', 'volume': '9', 'author': 'Lustig', 'year': '2021', 'journal-title': 'Lancet Respir. Med.'}, { 'key': 'ref_9', 'doi-asserted-by': 'crossref', 'unstructured': 'Radujkovic, A., Hippchen, T., Tiwari-Heckler, S., Dreher, S., Boxberger, ' 'M., and Merle, U. (2020). Vitamin D Deficiency and Outcome of COVID-19 ' 'Patients. Nutrients, 12.', 'DOI': '10.3390/nu12092757'}, { 'key': 'ref_10', 'doi-asserted-by': 'crossref', 'first-page': '1379', 'DOI': '10.1007/s10875-022-01325-2', 'article-title': 'Clinical and Immunological Features of SARS-CoV-2 Breakthrough ' 'Infections in Vaccinated Individuals Requiring Hospitalization', 'volume': '42', 'author': 'Lamacchia', 'year': '2022', 'journal-title': 'J. Clin. Immunol.'}, { 'key': 'ref_11', 'doi-asserted-by': 'crossref', 'first-page': '1170', 'DOI': '10.15585/mmwr.mm7034e5', 'article-title': 'SARS-CoV-2 Infections and Hospitalizations among Persons Aged ≥16 ' 'Years, by Vaccination Status—Los Angeles County, California, May 1–July ' '25, 2021', 'volume': '70', 'author': 'Griffin', 'year': '2021', 'journal-title': 'Morb. Mortal. Wkly. Rep.'}, { 'key': 'ref_12', 'doi-asserted-by': 'crossref', 'first-page': '875', 'DOI': '10.1016/j.mayocp.2021.01.001', 'article-title': 'Vitamin D Status Is Associated with In-Hospital Mortality and ' 'Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients', 'volume': '96', 'author': 'Angelidi', 'year': '2021', 'journal-title': 'Mayo Clin. Proc.'}, { 'key': 'ref_13', 'doi-asserted-by': 'crossref', 'unstructured': 'Dror, A.A., Morozov, N., Daoud, A., Namir, Y., Yakir, O., Shachar, Y., ' 'Lifshitz, M., Segal, E., Fisher, L., and Mizrachi, M. (2022). ' 'Pre-infection 25-hydroxyvitamin D3 levels and association with severity ' 'of COVID-19 illness. PLoS ONE, 17.', 'DOI': '10.1371/journal.pone.0263069'}, { 'key': 'ref_14', 'doi-asserted-by': 'crossref', 'unstructured': 'Barrett, R., Youssef, M., Shah, I., Ioana, J., Lawati, A.A., Bukhari, ' 'A., Hegarty, S., Cormican, L.J., Judge, E., and Burke, C.M. (2022). ' 'Vitamin D Status and Mortality from SARS CoV-2: A Prospective Study of ' 'Unvaccinated Caucasian Adults. Nutrients, 14.', 'DOI': '10.3390/nu14163252'}, { 'key': 'ref_15', 'doi-asserted-by': 'crossref', 'unstructured': 'Borsche, L., Glauner, B., and von Mendel, J. (2021). COVID-19 Mortality ' 'Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate ' 'Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: ' 'Results of a Systematic Review and Meta-Analysis. Nutrients, 13.', 'DOI': '10.1101/2021.09.22.21263977'}, { 'key': 'ref_16', 'doi-asserted-by': 'crossref', 'first-page': '665', 'DOI': '10.1093/qjmed/hcac040', 'article-title': 'Does vitamin D supplementation reduce COVID-19 severity? a systematic ' 'review', 'volume': '115', 'author': 'Shah', 'year': '2022', 'journal-title': 'QJM'}, { 'key': 'ref_17', 'first-page': 'e2269', 'article-title': 'Vitamin D supplementation and COVID-19 outcomes: A systematic review, ' 'meta-analysis and meta-regression', 'volume': '32', 'author': 'Hariyanto', 'year': '2022', 'journal-title': 'Rev. Med. Virol.'}, { 'key': 'ref_18', 'doi-asserted-by': 'crossref', 'first-page': '89', 'DOI': '10.1186/s12937-021-00744-y', 'article-title': 'Low vitamin D levels do not aggravate COVID-19 risk or death, and ' 'vitamin D supplementation does not improve outcomes in hospitalized ' 'patients with COVID-19: A meta-analysis and GRADE assessment of cohort ' 'studies and RCTs', 'volume': '20', 'author': 'Chen', 'year': '2021', 'journal-title': 'Nutr. J.'}, { 'key': 'ref_19', 'doi-asserted-by': 'crossref', 'first-page': 'R133', 'DOI': '10.1530/EJE-20-0665', 'article-title': 'Mechanisms In Endocrinology: Vitamin D and COVID-19', 'volume': '183', 'author': 'Bilezikian', 'year': '2020', 'journal-title': 'Eur. J. Endocrinol.'}, { 'key': 'ref_20', 'doi-asserted-by': 'crossref', 'unstructured': 'D’Ecclesiis, O., Gavioli, C., Martinoli, C., Raimondi, S., Chiocca, S., ' 'Miccolo, C., Bossi, P., Cortinovis, D., Chiaradonna, F., and Palorini, ' 'R. (2022). Vitamin D and SARS-CoV2 infection, severity and mortality: A ' 'systematic review and meta-analysis. PLoS ONE, 17.', 'DOI': '10.1371/journal.pone.0268396'}, { 'key': 'ref_21', 'doi-asserted-by': 'crossref', 'first-page': '736665', 'DOI': '10.3389/fpubh.2021.736665', 'article-title': 'Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical ' 'Outcomes', 'volume': '9', 'author': 'Chiodini', 'year': '2021', 'journal-title': 'Front. Public Health'}, { 'key': 'ref_22', 'doi-asserted-by': 'crossref', 'unstructured': 'Argano, C., Mallaci Bocchio, R., Natoli, G., Scibetta, S., Lo Monaco, ' 'M., and Corrao, S. (2023). Protective Effect of Vitamin D ' 'Supplementation on COVID-19-Related Intensive Care Hospitalization and ' 'Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential ' 'Analysis. Pharmaceuticals, 16.', 'DOI': '10.3390/ph16010130'}, { 'key': 'ref_23', 'doi-asserted-by': 'crossref', 'first-page': '53', 'DOI': '10.1007/s40618-021-01614-4', 'article-title': 'Vitamin D supplementation and clinical outcomes in COVID-19: A ' 'systematic review and meta-analysis', 'volume': '45', 'author': 'Pal', 'year': '2022', 'journal-title': 'J. Endocrinol. Investig.'}, { 'key': 'ref_24', 'doi-asserted-by': 'crossref', 'first-page': '1033', 'DOI': '10.3945/ajcn.115.120873', 'article-title': 'Vitamin D deficiency in Europe: Pandemic?', 'volume': '103', 'author': 'Cashman', 'year': '2016', 'journal-title': 'Am. J. Clin. Nutr.'}, { 'key': 'ref_25', 'doi-asserted-by': 'crossref', 'first-page': 'e1909', 'DOI': '10.1002/rmv.1909', 'article-title': 'Vitamin D modulation of innate immune responses to respiratory viral ' 'infections', 'volume': '27', 'author': 'Zdrenghea', 'year': '2017', 'journal-title': 'Rev. Med. Virol.'}, { 'key': 'ref_26', 'doi-asserted-by': 'crossref', 'first-page': '13', 'DOI': '10.2147/JIR.S282213', 'article-title': 'Understanding COVID-19 Pandemic: Molecular Mechanisms and Potential ' 'Therapeutic Strategies. An Evidence-Based Review', 'volume': '14', 'author': 'Hanna', 'year': '2021', 'journal-title': 'J. Inflamm. Res.'}, { 'key': 'ref_27', 'doi-asserted-by': 'crossref', 'first-page': '62', 'DOI': '10.1038/s41590-021-01080-3', 'article-title': 'Autocrine vitamin D signaling switches off pro-inflammatory programs of ' 'TH1 cells', 'volume': '23', 'author': 'Chauss', 'year': '2022', 'journal-title': 'Nat. Immunol.'}, { 'key': 'ref_28', 'doi-asserted-by': 'crossref', 'first-page': '15', 'DOI': '10.1007/s15010-020-01509-1', 'article-title': 'Risk factors for COVID-19 severity and fatality: A structured ' 'literature review', 'volume': '49', 'author': 'Wolff', 'year': '2021', 'journal-title': 'Infection'}, { 'key': 'ref_29', 'doi-asserted-by': 'crossref', 'first-page': '881', 'DOI': '10.2310/JIM.0b013e31821b8755', 'article-title': 'Vitamin D and the immune system', 'volume': '59', 'author': 'Aranow', 'year': '2011', 'journal-title': 'J. Investig. Med.'}, { 'key': 'ref_30', 'doi-asserted-by': 'crossref', 'first-page': '20191', 'DOI': '10.1038/s41598-020-77093-z', 'article-title': 'Analysis of vitamin D level among asymptomatic and critically ill ' 'COVID-19 patients and its correlation with inflammatory markers', 'volume': '10', 'author': 'Jain', 'year': '2020', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_31', 'doi-asserted-by': 'crossref', 'first-page': '835480', 'DOI': '10.3389/fphar.2022.835480', 'article-title': 'Understanding a Low Vitamin D State in the Context of COVID-19', 'volume': '13', 'author': 'Walsh', 'year': '2022', 'journal-title': 'Front. Pharmacol.'}, { 'key': 'ref_32', 'first-page': 'P733', 'article-title': 'The Causal Role of Vitamin D Deficiency in Worse COVID-19 Outcomes: ' 'Implications for Policy and Practice Development', 'volume': '116', 'author': 'McCartney', 'year': '2023', 'journal-title': 'Ir. Med. J.'}, { 'key': 'ref_33', 'doi-asserted-by': 'crossref', 'first-page': '73', 'DOI': '10.1186/s12986-020-00491-7', 'article-title': 'Systemic vitamin intake impacting tissue proteomes', 'volume': '17', 'author': 'Jeong', 'year': '2020', 'journal-title': 'Nutr. Metab.'}], 'container-title': 'Nutrients', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/2072-6643/15/13/2976/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 7, 3]], 'date-time': '2023-07-03T04:50:49Z', 'timestamp': 1688359849000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2072-6643/15/13/2976'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 6, 30]]}, 'references-count': 33, 'journal-issue': {'issue': '13', 'published-online': {'date-parts': [[2023, 7]]}}, 'alternative-id': ['nu15132976'], 'URL': 'http://dx.doi.org/10.3390/nu15132976', 'relation': {}, 'ISSN': ['2072-6643'], 'subject': ['Food Science', 'Nutrition and Dietetics'], 'container-title-short': 'Nutrients', 'published': {'date-parts': [[2023, 6, 30]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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