October 2026
Nitric oxide COVID-19 outcomes
StudyImprovementRR ยท 95% CIOutcomeTreatmentControlRelative Risk
Winchester (DB RCT)42%0.58 ยท 0.36โ0.94no improv.8/1523/25
Winchester (DB RCT)51%0.49 ยท 0.32โ0.75viral load40 (n)40 (n)
Tandon (DB RCT)68%0.32 ยท 0.09โ1.12no improv.3/6410/69
Tandon (DB RCT)67%0.33 ยท 0.11โ0.97no improv.4/6413/69
Tandon (DB RCT)42%0.58 ยท 0.33โ1.01no improv.14/6426/69
Tandon (DB RCT)22%0.78 ยท 0.32โ1.89no improv.8/10510/102
Tandon (DB RCT)18%0.82 ยท 0.39โ1.75no improv.11/10513/102
Tandon (DB RCT)9%0.91 ยท 0.60โ1.38no improv.30/10532/102
Tandon (DB RCT)20%0.80 ยท 0.75โ0.86viral load64 (n)69 (n)
Tandon (DB RCT)14%0.86 ยท 0.83โ0.90viral load105 (n)102 (n)
Tandon (DB RCT)26%0.74 ยท 0.52โ1.05viral time64 (n)69 (n)
Tandon (DB RCT)6%0.94 ยท 0.70โ1.25viral time105 (n)102 (n)
Bryan (DB RCT)โ1%1.01 ยท 0.21โ4.95progression3/2613/263
Bryan (DB RCT)11%0.89 ยท 0.71โ1.11recov. time261 (n)263 (n)
Chandelโ54%1.54 ยท 0.72โ2.78death12/6636/206
Chandelโ27%1.27 ยท 0.82โ1.73ventilation29/6679/206
Moni (RCT)90%0.10 ยท 0.01โ1.67death0/144/11ICU patients
Moni (RCT)90%0.10 ยท 0.01โ1.67ventilation0/144/11ICU patients
Moni (RCT)42%0.58 ยท 0.05โ1.00no improv.3/147/11ICU patients
Moni (RCT)64%0.36 ยท 0.17โ0.74viral load14 (n)11 (n)ICU patients
Moni (RCT)63%0.37 ยท 0.18โ0.75viral load14 (n)11 (n)ICU patients
Strickland (RCT)โ179%2.79 ยท 0.12โ63.96ventilation1/190/15
Strickland (RCT)21%0.79 ยท 0.05โ11.61hosp.1/191/15
Strickland (RCT)โ38%1.38 ยท 0.50โ3.85misc.7/194/15
Poonam14%0.86 ยท 0.72โ1.04death32/4156/62Ventilated patients OT1
Valsecchi58%0.42 ยท 0.02โ9.86death0/201/51
Valsecchi68%0.32 ยท 0.08โ1.26ventilation2/2016/51
Valsecchi39%0.61 ยท 0.27โ1.39ICU5/2021/51
Di Fenza (SB RCT)23%0.77 ยท 0.44โ1.32death94 (n)99 (n)NOSARSCOVIDVentilated patients
Di Fenza (SB RCT)26%0.74 ยท 0.39โ1.40death94 (n)99 (n)NOSARSCOVIDVentilated patients
Di Fenza (SB RCT)13%0.87 ยท 0.52โ1.43death94 (n)99 (n)NOSARSCOVIDVentilated patients
Di Fenza (SB RCT)15%0.85 ยท 0.50โ1.46death94 (n)99 (n)NOSARSCOVIDVentilated patients
Di Fenza (SB RCT)30%0.70 ยท 0.14โ3.39progression94 (n)99 (n)NOSARSCOVIDVentilated patients
Di Fenza (SB RCT)83%0.17 ยท 0.04โ0.62misc.94 (n)99 (n)NOSARSCOVIDVentilated patients
Wolak (RCT)64%0.36 ยท 0.14โ0.91oxygen16 (n)19 (n)
Wolak (RCT)81%0.19 ยท 0.03โ1.00oxygen16 (n)19 (n)
Wolak (RCT)41%0.59 ยท 0.24โ1.43hosp.16 (n)19 (n)
Friedrich (RCT)โ50%1.50 ยท 0.27โ8.28death3/272/27iNO-COVID-19
Friedrich (RCT)50%0.50 ยท 0.24โ1.04oxygen7/2714/27iNO-COVID-19
Friedrich (RCT)35%0.65 ยท 0.41โ1.02oxygen13/2720/27iNO-COVID-19
Friedrich (RCT)31%0.69 ยท 0.52โ0.91oxygen18/2726/27iNO-COVID-19
Friedrich (RCT)0%1.00 ยท 0.33โ3.06progression5/275/27iNO-COVID-19
Friedrich (RCT)36%0.64 ยท 0.49โ0.84hosp. time27 (n)27 (n)iNO-COVID-19
Kurnik (ICU)23%0.77 ยท 0.38โ1.59death3/597/125ICU patients
Berra (RCT)65%0.35 ยท 0.01โ8.21death0/291/33NoCovid
Berra (RCT)โ14%1.14 ยท 0.07โ17.39ventilation1/291/33NoCovid
Miller75%0.25 ยท 0.14โ0.43cases13/203108/422
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