Enhanced fatty acid oxidation through Metformin and Baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney
Retrospective study showing shorter ICU stay with metformin, animal study showing that metformin minimized lung damage in an ARDS model, and
in vitro study showing increased mitochondrial function and decreased TGF-β-induced fibrosis, apoptosis, and inflammation markers in lung epithelial cells. Currently there is only an abstract available.
2 In Vitro studies support the efficacy of metformin
[Miguel, Parthasarathy].
Miguel et al., 19 May 2023, retrospective, Spain, peer-reviewed, 17 authors.
Abstract: Abstracts
Free Radical Biology and Medicine 201 (2023) 1–64
Jose Miguel Rodríguez Gonzalez-Moro 3, Santiago Lamas 1. 1 Program of
Physiological and Pathological Processes, Centro de Biología Molecular "Severo
Ochoa” (CBMSO) (CSIC-UAM), Madrid, Spain; 2 Department of Pathology.
University Hospital "Príncipe de Asturias", Alcal
a de Henares, Madrid, Spain;
3
Department of Pneumology, University Hospital “Principe de Asturias”, Alcala de
Henares, Madrid, Spain; 4 Institute for Computational Genomics, RWTH Aachen
University Hospital, Aachen, Germany; 5 Joint Research Center for Computational
Biomedicine, RWTH Aachen University Hospital, Aachen, Germany; 6 Institute of
Experimental Medicine and Systems Biology, RWTH Aachen University Hospital,
Aachen, Germany; 7 Institute for Biomedical Technologies, Department of Cell
Biology, RWTH Aachen University, Aachen, Germany; 8 Department of Nephrology
and Hypertensive Disorders, Rheumatology, and Clinical Immunology (Medical
Clinic II), University Hospital RWTH Aachen, Germany; 9 Department of
Pathology, Radboud Institute for Molecular Life Sciences, Radboud University
Medical Center, Nijmegen, The Netherlands; 10 Instituto de Química Medica (IQMCSIC), Madrid, Spain
as subfertility, congenital anomalies, and neuropsychiatric disorders in the
offspring. Studies conducted on sperm samples offer a perspective limited to the
outcome of age- and oxidative stress-related mechanisms that affect spermatogenesis, completely ignoring what happens to the precursor germ cells of spermatozoa. Germ cells reside inside the seminiferous tubules of the testicles and
experience complex differentiation processes that are sensitive to free radicals
and other ROS. Using the D-Galactose mouse model of accelerated aging, we
studied free radical production in different types of germ cells, peritubular myoid
cells, and also in Sertoli cells, the nurse cells for spermatogenesis. We think that
the single-cell reporting capacity of diamond magnetometry applied for the first
time to the complex scenario of the male germ line is attractive for the field of
Reproductive Medicine and highlights the versatility of nanodiamonds as
nanoscale biosensors.
doi: https://doi.org/10.1016/j.freeradbiomed.2023.03.184
PP IX_89
* Corresponding author
BCL-XL, A MITOCHONDRIAL PROTEIN INVOLVED IN SUCCESSFUL AGING
AND FRAILTY PREVENTION
Progressive respiratory failure is the primary cause of death in the coronavirus
disease 2019 (COVID-19) pandemic. It is the final outcome of the acute respiratory distress syndrome (ARDS), characterized by an initial exacerbated inflammatory response and ultimate tissue scarring. Energy balance may be crucial
for the recovery of clinical COVID-19. Hence, we asked if two key pathways
involved in energy generation, AMP-activated protein kinase (AMPK)/acetylCoA carboxylase (ACC) signaling and fatty acid oxidation (FAO) could be
beneficial. We tested the drugs Metformin (AMPk activator) and Baicalin (Cpt1A
activator) in different experimental models mimicking COVID-19 associated
inflammation in lung and kidney. We also studied two different cohorts of
COVID19 patients that had been previously treated with Metformin. These drugs
ameliorated lung damage in an ARDS animal model, while activation of AMPK/
ACC signaling increased mitochondrial function and decreased TGF-β-induced
fibrosis, apoptosis and inflammation markers in lung epithelial cells. Similar
results were observed with two new indole derivatives IND6 and..
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