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Merck and Ridgeback Biotherapeutics Provide Update on Progress of Clinical Development Program for Molnupiravir, an Investigational Oral Therapeutic for the Treatment of Mild-to-Moderate COVID-19
Merck, News Release (Preprint), NCT04575584 (history)
Merck, Merck and Ridgeback Biotherapeutics Provide Update on Progress of Clinical Development Program for.., , News Release (Preprint), NCT04575584
Apr 2021   Source   PDF  
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News release reporting that the trial of molnupiravir with hospitalized patients (NCT04575584 (history)) has been discontinued because data indicates it is unlikely to demonstrate a clinical benefit in hospitalized patients. Results are not available yet. Interim results for the trial with outpatients show positive dose-dependent results for viral clearance.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom]. See [Fountain-Jones, Sanderson, twitter.com] for analysis of variants potentially created by molnupiravir.
Merck et al., 15 Apr 2021, preprint, 1 author, trial NCT04575584 (history).
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Late treatment
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