Remdesivir for the treatment of COVID-19 disease: A retrospective comparative study of patients treated with and without Remdesivir
Madan et al.,
Remdesivir for the treatment of COVID-19 disease: A retrospective comparative study of patients treated with..,
medRxiv, doi:10.1101/2021.07.15.21260600 (Preprint)
Retrospective 1,262 hospitalized patients, 398 treated with remdesivir, showing unadjusted lower mortality with treatment, and a treatment delay-response relationship.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
This study is excluded in the after exclusion results of meta
analysis:
excessive unadjusted differences between groups.
risk of death, 44.4% lower, RR 0.56, p = 0.03, treatment 23 of 398 (5.8%), control 27 of 260 (10.4%), NNT 22, unadjusted.
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risk of death, 65.6% lower, RR 0.34, p = 0.04, treatment 4 of 112 (3.6%), control 27 of 260 (10.4%), NNT 15, unadjusted, <5 days from onset.
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risk of death, 61.7% lower, RR 0.38, p = 0.009, treatment 9 of 226 (4.0%), control 27 of 260 (10.4%), NNT 16, unadjusted, 5-10 days from onset.
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risk of death, 60.5% higher, RR 1.60, p = 0.18, treatment 10 of 60 (16.7%), control 27 of 260 (10.4%), unadjusted, >10 days from onset.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Madan et al., 19 Jul 2021, retrospective, India, preprint, 22 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.07.15.21260600; this version posted July 19, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Title:
Remdesivir for the treatment of COVID-19 disease: A retrospective comparative study of
patients treated with and without Remdesivir
Authors names and affiliations
Surabhi Madan
Department of Infectious Diseases
Care Institute of Medical Sciences
Ahmedabad, India
Amit Patel
Department of Pulmonary Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Kartikae Sharan
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Shayon Ghosh
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Vishnu Venugopal
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Nitesh Shah
Department of Pulmonary Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Bhagyesh Shah
Department of Critical Care Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Vipul Thakkar
Department of Critical Care Medicine
Care Institute of Medical Sciences
Ahmedabad, India
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2021.07.15.21260600; this version posted July 19, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Rashmi Chovatiya
Department of Internal Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Hardik Shah
Department of Internal Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Pradip Dabhi
Department of Pulmonary Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Minesh Patel
Department of Critical Care Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Bhowmik Meghnathi
Department of Internal Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Vineet Sankhla
Department of Cardiology
Care Institute of Medical Sciences
Ahmedabad, India
Vipul Kapoor
Department of Cardiology
Care Institute of Medical Sciences
Ahmedabad, India
Tejas Patel
Department of Internal Medicine
Care Institute of Medical Sciences
Ahmedabad, India
Maulik Soni
Department of Pulmonary Medicine
Care Institute of Medical Sciences
Ahmedabad, India
medRxiv preprint doi: https://doi.org/10.1101/2021.07.15.21260600; this version posted July 19, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Nirav Bapat
Department of Community Medicine
GMERS Medical College, Sola
Ahmedabad, India
Kaivan Shah
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Ritanshu Chandarana
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Parloop Bhatt
Department of Clinical Research
Care Institute of Medical Sciences
Ahmedabad, India
Manish Rana
Department of Community Medicine
GMERS Medical College, Sola
Ahmedabad,..
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