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A single-center retrospective cohort study of Covid-19 medications: Remdesivir, Favipiravir, Methylprednisolone, Dexamethasone, and Interferon β1a and their combinations

Fateh et al., medRxiv, doi:10.1101/2021.03.05.21251351
Mar 2021  
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Retrospective 324 hospitalized patients in Iran reporting on the use remdesivir, favipiravir, methylprednisolone, dexamethasone, and interferon β1a and their combinations. There is no control group in this study, however authors suggest that interferon β1a, corticosteroids, and remdesivir may not have a significant effect on mortality of hospitalization time.
Gérard, Wu, Zhou show significantly increased risk of acute kidney injury with remdesivir.
Study covers favipiravir and remdesivir.
Fateh et al., 8 Mar 2021, retrospective, Iran, preprint, 7 authors.
This PaperRemdesivirAll
A single-center retrospective cohort study of Covid-19 medications: Remdesivir, Favipiravir, Methylprednisolone, Dexamethasone, and Interferon β1a and their combinations
Sahand Tehrani Fateh, Sepand Tehrani Fateh, Esmaeil Salehi, Nima Rezai, Nazanin Haririan, Abdollah Asgari, Amir Salehi-Najafabadi
Many drugs have been suggested to be used for Covid-19. A suitable and efficient choice of drug would make the course of Covid-19 easier. we have investigated the efficacy of different treatment regimen in reducing hospitalization period (HP) and mortality of 324 confirmed Covid-19 patients. Received drugs included single therapy or combinations of Methylprednisolone, Remdesivir, Favipiravir, Interferon β1a, and Dexamethasone. HP and mortality were compared between different treatment groups to evaluate efficacy of each drug. HP and mortality were also calculated for patients in each treatment group based on their underlying diseases and age. we suggest that using IFN-β1a, RDV and corticosteroids might not have a significant effect on the HP or mortality of the Covid-19 patients as it was thought before.
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Late treatment
is less effective
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