Favipiravir Effectiveness and Safety in Hospitalized Moderate-Severe COVID-19 Patients: Observational Prospective Multicenter Investigation in Saudi Arabia

DOI record: { "DOI": "10.3389/fmed.2022.826247", "ISSN": [ "2296-858X" ], "URL": "http://dx.doi.org/10.3389/fmed.2022.826247", "abstract": "<jats:sec><jats:title>Objectives</jats:title><jats:p>There are limited data on the efficacy and safety of favipiravir antiviral in coronavirus disease 2019 (COVID-19), particularly in the more progressed disease phase. This study aims to evaluate the favipiravir effect on reducing the length of hospital stay and in-hospital mortality among moderate and severe hospitalized COVID-19 patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A prospective, multicenter observational study was conducted that included moderate and severe hospitalized adult COVID-19 patients in four major regions (Riyadh (Riyadh), Eastern (Dammam), Al-Qassem (Buraydah), and Macca (Jeddah) of Saudi Arabia. For the primary outcome of all-cause mortality, a Cox proportional hazard analysis was performed. While the association between favipiravir use and length of hospital stay was determined using adjusted generalized linear model. This study was approved by the Central Institutional Review Board in The Saudi Ministry of Health (MoH) with the approval number IRB # 20-85-M.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>This study included 598 moderate and severe COVID-19 patients, of whom 156 (26%) received favipiravir. Favipiravir treatment was associated with more extended hospital stays (14 vs. 10 median days, <jats:italic>P</jats:italic> = 0.034) and higher mortality rate (aHR 3.63; 95% CI 1.06–12.45) compared to no favipiravir regimen. Despite lack of effectiveness, favipiravir use was only associated with higher diarrhea adverse effects (12 vs. 5%, <jats:italic>P</jats:italic> = 0.002), but it did not affect the renal and liver profiles of patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Favipiravir was ineffective in reducing the length of hospital stay and in-hospital mortality in patients with moderate and severe COVID-19.</jats:p></jats:sec>", "alternative-id": [ "10.3389/fmed.2022.826247" ], "author": [ { "affiliation": [], "family": "Al-Muhsen", "given": "Saleh", "sequence": "first" }, { "affiliation": [], "family": "Al-Numair", "given": "Nouf S.", "sequence": "additional" }, { "affiliation": [], "family": "Saheb Sharif-Askari", "given": "Narjes", "sequence": "additional" }, { "affiliation": [], "family": "Basamh", "given": "Roaa", "sequence": "additional" }, { "affiliation": [], "family": "Alyounes", "given": "Banan", "sequence": "additional" }, { "affiliation": [], "family": "Jabaan", "given": "Amjad", "sequence": "additional" }, { "affiliation": [], "family": "Saheb Sharif-Askari", "given": "Fatemeh", "sequence": "additional" }, { "affiliation": [], "family": "Alosaimi", "given": "Mohammed F.", "sequence": "additional" }, { "affiliation": [], "family": "Alsohime", "given": "Fahad", "sequence": "additional" }, { "affiliation": [], "family": "Halwani", "given": "Rabih", "sequence": "additional" }, { "affiliation": [], "family": "Al-Saud", "given": "Haya", "sequence": "additional" } ], "container-title": "Frontiers in Medicine", "container-title-short": "Front. Med.", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2022, 3, 4 ] ], "date-time": "2022-03-04T09:52:22Z", "timestamp": 1646387542000 }, "deposited": { "date-parts": [ [ 2022, 3, 4 ] ], "date-time": "2022-03-04T09:52:23Z", "timestamp": 1646387543000 }, "indexed": { "date-parts": [ [ 2022, 4, 3 ] ], "date-time": "2022-04-03T15:33:59Z", "timestamp": 1649000039744 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 3, 4 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 4 ] ], "date-time": "2022-03-04T00:00:00Z", "timestamp": 1646352000000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fmed.2022.826247/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2022, 3, 4 ] ] }, "published-online": { "date-parts": [ [ 2022, 3, 4 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.1073/pnas.2024302118", "article-title": "Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay", "author": "Jang", "doi-asserted-by": "publisher", "first-page": "e2024302118", "journal-title": "Proc Nat Acad Sci USA.", "key": "B1", "volume": "118", "year": "2021" }, { "DOI": "10.2183/pjab.93.027", "article-title": "Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase", "author": "Furuta", "doi-asserted-by": "publisher", "first-page": "449", "journal-title": "Proc Jpn Acad Ser B Phys Biol Sci.", "key": "B2", "volume": "93", "year": "2017" }, { "DOI": "10.1017/dmp.2014.151", "article-title": "Favipiravir: a new medication for the Ebola virus disease pandemic", "author": "Nagata", "doi-asserted-by": "publisher", "first-page": "79", "journal-title": "Disaster Med Public Health Prep.", "key": "B3", "volume": "9", "year": "2015" }, { "DOI": "10.3201/eid2409.180233", "article-title": "Use of favipiravir to treat lassa virus infection in macaques", "author": "Rosenke", "doi-asserted-by": "publisher", "first-page": "1696", "journal-title": "Emerg Infect Dis.", "key": "B4", "volume": "24", "year": "2018" }, { "DOI": "10.1002/cpt.2251", "article-title": "Japan's drug regulation during the COVID-19 pandemic: lessons from a case study of favipiravir", "author": "Ueda", "doi-asserted-by": "publisher", "first-page": "545", "journal-title": "Clin Pharmacol Ther", "key": "B5", "volume": "113", "year": "2021" }, { "DOI": "10.1186/s12879-021-06164-x", "article-title": "Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis", "author": "Manabe", "doi-asserted-by": "publisher", "first-page": "489", "journal-title": "BMC Infect Dis.", "key": "B6", "volume": "21", "year": "2021" }, { "DOI": "10.2139/ssrn.3829663", "article-title": "Favipiravir and hydroxychloroquine combination therapy in patients with moderate to severe COVID-19 (FACCT Trial): an open-label, multicenter, randomized, controlled trial", "author": "Bosaeed", "doi-asserted-by": "publisher", "first-page": "2291", "journal-title": "Infect Dis Therapy.", "key": "B7", "volume": "10", "year": "2021" }, { "DOI": "10.1371/journal.pone.0252984", "article-title": "Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: a cohort study", "author": "A. Malhani", "doi-asserted-by": "publisher", "first-page": "e0252984", "journal-title": "PLoS ONE", "key": "B8", "volume": "16", "year": "2021" }, { "DOI": "10.1007/s10096-021-04307-1", "article-title": "Effectiveness of favipiravir in COVID-19: a live systematic review", "author": "Özlüşen", "doi-asserted-by": "publisher", "first-page": "2575", "journal-title": "Eur J Clin Microbiol Infect Dis.", "key": "B9", "volume": "40", "year": "2021" }, { "DOI": "10.1080/03007995.2021.1920900", "article-title": "Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis", "author": "Alamer", "doi-asserted-by": "publisher", "first-page": "1085", "journal-title": "Curr Med Res Opin.", "key": "B10", "volume": "37", "year": "2021" }, { "DOI": "10.1038/s41598-021-90551-6", "article-title": "Martinez-de-Hoyo R. The efficacy and safety of Favipiravir in treatment of COVID-19: a systematic review and meta-analysis of clinical trials", "author": "Hassanipour", "doi-asserted-by": "publisher", "first-page": "11022", "journal-title": "Sci Rep.", "key": "B11", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.jclinepi.2008.06.022", "article-title": "Conclusion about the association between valve surgery and mortality in an infective endocarditis cohort changed after adjusting for survivor bias", "author": "Tleyjeh", "doi-asserted-by": "publisher", "first-page": "130", "journal-title": "J Clin Epidemiol.", "key": "B12", "volume": "63", "year": "2010" }, { "DOI": "10.1371/journal.pone.0258643", "article-title": "Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: a retrospective cohort study", "author": "Hussain Alsayed", "doi-asserted-by": "publisher", "first-page": "e0258643", "journal-title": "PLoS ONE.", "key": "B13", "volume": "16", "year": "2021" }, { "DOI": "10.1016/j.eng.2020.03.007", "article-title": "Experimental treatment with favipiravir for COVID-19: an open-label control study", "author": "Cai", "doi-asserted-by": "publisher", "first-page": "1192", "journal-title": "Engineering.", "key": "B14", "volume": "6", "year": "2020" }, { "DOI": "10.1016/j.ijid.2020.11.142", "article-title": "Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: a randomized, comparative, open-label, multicenter, phase 3 clinical trial", "author": "Udwadia", "doi-asserted-by": "publisher", "first-page": "62", "journal-title": "Int J Infect Dis.", "key": "B15", "volume": "103", "year": "2021" }, { "DOI": "10.1001/jama.2020.2783", "article-title": "Positive RT-PCR test results in patients recovered from COVID-19", "author": "Lan", "doi-asserted-by": "publisher", "first-page": "1502", "journal-title": "JAMA.", "key": "B16", "volume": "323", "year": "2020" }, { "DOI": "10.1038/s41467-021-21992-w", "article-title": "Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model", "author": "Driouich", "doi-asserted-by": "publisher", "first-page": "1735", "journal-title": "Nat Commun.", "key": "B17", "volume": "12", "year": "2021" }, { "DOI": "10.1111/cts.12827", "article-title": "Population pharmacokinetics of favipiravir in patients with COVID-19", "author": "Irie", "doi-asserted-by": "publisher", "first-page": "1161", "journal-title": "CPT Pharmacometrics Syst Pharmacol.", "key": "B18", "volume": "10", "year": "2021" }, { "DOI": "10.1056/NEJMoa2021436", "article-title": "Dexamethasone in hospitalized patients with Covid-19", "doi-asserted-by": "publisher", "first-page": "693", "journal-title": "N Engl J Med", "key": "B19", "volume": "384", "year": "2020" }, { "DOI": "10.1016/j.jinf.2020.09.022", "article-title": "Neutrophil-to-lymphocyte ratio on admission is an independent risk factor for the severity and mortality in patients with coronavirus disease 2019", "author": "Wang", "doi-asserted-by": "publisher", "first-page": "e16", "journal-title": "J Infect.", "key": "B20", "volume": "82", "year": "2021" }, { "DOI": "10.1002/jmv.26061", "article-title": "Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: a retrospective cross-sectional study", "author": "Yan", "doi-asserted-by": "publisher", "first-page": "2573", "journal-title": "J Med Virol.", "key": "B21", "volume": "92", "year": "2020" } ], "reference-count": 21, "references-count": 21, "relation": {}, "resource": { "primary": { "URL": "https://www.frontiersin.org/articles/10.3389/fmed.2022.826247/full" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "General Medicine" ], "subtitle": [], "title": "Favipiravir Effectiveness and Safety in Hospitalized Moderate-Severe COVID-19 Patients: Observational Prospective Multicenter Investigation in Saudi Arabia", "type": "journal-article", "update-policy": "http://dx.doi.org/10.3389/crossmark-policy", "volume": "9" }