Liver injury in non-severe COVID-19 with various pandemic phases: a real-world study

DOI record: { "DOI": "10.21203/rs.3.rs-3484296/v1", "URL": "http://dx.doi.org/10.21203/rs.3.rs-3484296/v1", "abstract": "<jats:title>Abstract</jats:title>\n <jats:p>The using of a variety of anti-COVID-19 medicines connected to the degree of liver impairment in the short term was intriguing. To evaluate the dynamic course of liver injury in patients with mild to moderate COVID-19 within 10 days of admission. This was a prospective cohort study of 300 patients who were newly proven mild to moderate COVID-19 between September 2021 and October 2022. There were 188 patients in hospitel/field hospital (n = 188) and cohort wards (n = 112). One hundred and fifteen patients (38.3%) suffered from liver injury (LI). The majority of Group LI participants (n = 104) received medication to treat the COVID-19 infection, including favipiravir (45%), remdesivir (17.4%), molnupiravir (11.3%), Andrographis paniculata (ADG) (8.7%), and favipiravir in combination with ivermectin (7.7%). When compared to no LI, molnupiravir medication was linked with the largest proportion of transaminase &lt; 2 and 2–5 times the ULN [11.3% vs. 4.9%, p = 0.038; 15.2% vs. 4.9%, p = 0.013]. After 10 days, the majority of patients exhibited a transaminase decline. A less-than-critical level of liver damage was reported in mild to moderate COVID-19 that allows clinicians to administer a variety of standard medications during short periods of hospital stay.</jats:p>", "accepted": { "date-parts": [ [ 2023, 10, 24 ] ] }, "author": [ { "affiliation": [ { "name": "Vajira Hospital, Navamindradhiraj University" } ], "family": "Winyupakorn", "given": "Jirayuth", "sequence": "first" }, { "affiliation": [ { "name": "Vajira Hospital, Navamindradhiraj University" } ], "family": "Sangketchon", "given": "Chunlanee", "sequence": "additional" }, { "affiliation": [ { "name": "Vajira Hospital, Navamindradhiraj University" } ], "family": "Ayutthaya", "given": "Watcharaporn Devakul Na", "sequence": "additional" }, { "affiliation": [ { "name": "Vajira Hospital, Navamindradhiraj University" } ], "family": "Sethasine", "given": "Supatsri", "sequence": "additional" } ], "container-title": [], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2023, 10, 31 ] ], "date-time": "2023-10-31T20:51:28Z", "timestamp": 1698785488000 }, "deposited": { "date-parts": [ [ 2023, 10, 31 ] ], "date-time": "2023-10-31T20:51:52Z", "timestamp": 1698785512000 }, "group-title": "In Review", "indexed": { "date-parts": [ [ 2023, 11, 1 ] ], "date-time": "2023-11-01T07:04:38Z", "timestamp": 1698822278273 }, "institution": [ { "name": "Research Square" } ], "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2023, 10, 31 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 10, 31 ] ], "date-time": "2023-10-31T00:00:00Z", "timestamp": 1698710400000 } } ], "link": [ { "URL": "https://www.researchsquare.com/article/rs-3484296/v1", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://www.researchsquare.com/article/rs-3484296/v1.html", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "8761", "original-title": [], "posted": { "date-parts": [ [ 2023, 10, 31 ] ] }, "prefix": "10.21203", "published": { "date-parts": [ [ 2023, 10, 31 ] ] }, "publisher": "Research Square Platform LLC", "reference": [ { "DOI": "10.1016/j.jhep.2020.09.031", "article-title": "COVID-19: Discovery, diagnostics and drug development", "author": "Asselah T", "doi-asserted-by": "crossref", "first-page": "168", "issue": "1", "journal-title": "J Hepatol", "key": "ref1", "unstructured": "Asselah T, Durantel D, Pasmant E, Lau G, Schinazi RF. 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