Antiviral effectiveness and survival correlation of azvudine and nirmatrelvir/ritonavir in elderly severe patients with COVID-19: a retrospective real-world study

{ 'indexed': {'date-parts': [[2024, 4, 1]], 'date-time': '2024-04-01T17:19:39Z', 'timestamp': 1711991979120}, 'reference-count': 24, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2024, 3, 1]], 'date-time': '2024-03-01T00:00:00Z', 'timestamp': 1709251200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2024, 1, 19]], 'date-time': '2024-01-19T00:00:00Z', 'timestamp': 1705622400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100012165', 'name': 'Key Technologies Research and Development Program', 'doi-asserted-by': 'publisher', 'award': ['2020YFC2008900']}, { 'DOI': '10.13039/501100012166', 'name': 'National Key Research and Development Program of China', 'doi-asserted-by': 'publisher'}, { 'DOI': '10.13039/501100017548', 'name': 'National Defense Science and Technology Innovation Fund of the Chinese Academy of ' 'Sciences', 'doi-asserted-by': 'publisher', 'award': ['223-CXCY-N101-07-18-01']}], 'content-domain': { 'domain': ['thelancet.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 3]]}, 'DOI': '10.1016/j.eclinm.2024.102468', 'type': 'journal-article', 'created': {'date-parts': [[2024, 2, 9]], 'date-time': '2024-02-09T07:18:25Z', 'timestamp': 1707463105000}, 'page': '102468', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Antiviral effectiveness and survival correlation of azvudine and nirmatrelvir/ritonavir in ' 'elderly severe patients with COVID-19: a retrospective real-world study', 'prefix': '10.1016', 'volume': '69', 'author': [ {'given': 'Shuxia', 'family': 'Wang', 'sequence': 'first', 'affiliation': []}, {'given': 'Jin', 'family': 'Sun', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xin', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Man', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bangguo', 'family': 'Qin', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-7975-6702', 'authenticated-orcid': False, 'given': 'Miao', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nan', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shengshu', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tingyu', 'family': 'Zhou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wei', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cong', 'family': 'Ma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xinli', 'family': 'Deng', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yongyi', 'family': 'Bai', 'sequence': 'additional', 'affiliation': []}, {'given': 'Geping', 'family': 'Qu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lin', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hui', 'family': 'Shi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bo', 'family': 'Zhou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ke', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bo', 'family': 'Yang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Suxia', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fan', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jinling', 'family': 'Ma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lu', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yajuan', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Li', 'family': 'An', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wenhui', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qing', 'family': 'Chang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ru', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xi', 'family': 'Yin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yang', 'family': 'Yang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qiangguo', 'family': 'Ao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qiang', 'family': 'Ma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shuangtong', 'family': 'Yan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Haili', 'family': 'Huang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Peng', 'family': 'Song', 'sequence': 'additional', 'affiliation': []}, {'given': 'Linggen', 'family': 'Gao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wenning', 'family': 'Lu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lining', 'family': 'Xu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Li', 'family': 'Lei', 'sequence': 'additional', 'affiliation': []}, {'given': 'Keyu', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qi', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qing', 'family': 'Song', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zhijian', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xiangqun', 'family': 'Fang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yao', 'family': 'He', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tianzhi', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0009-0007-4161-1640', 'authenticated-orcid': False, 'given': 'Ping', 'family': 'Zhu', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.eclinm.2024.102468_bib1', 'series-title': 'China grants conditional approval for Pfizer’s oral COVID-19 drug', 'year': '2022'}, { 'key': '10.1016/j.eclinm.2024.102468_bib2', 'series-title': 'Domestically developed drug joins virus battle', 'year': '2022'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2024.102468_bib3', 'doi-asserted-by': 'crossref', 'first-page': '414', 'DOI': '10.1038/s41392-021-00835-6', 'article-title': 'Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating ' 'COVID-19 patients', 'volume': '6', 'author': 'Zhang', 'year': '2021', 'journal-title': 'Signal Transduct Targeted Ther'}, { 'issue': '3', 'key': '10.1016/j.eclinm.2024.102468_bib4', 'doi-asserted-by': 'crossref', 'first-page': 'e342', 'DOI': '10.1093/cid/ciac443', 'article-title': 'Effectiveness of paxlovid in reducing severe coronavirus disease 2019 ' 'and mortality in high-risk patients', 'volume': '76', 'author': 'Najjar-Debbiny', 'year': '2023', 'journal-title': 'Clin Infect Dis'}, { 'issue': '9', 'key': '10.1016/j.eclinm.2024.102468_bib5', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.heliyon.2023.e20153', 'article-title': 'Efficacy and safety of azvudine in patients with COVID-19: a systematic ' 'review and meta-analysis', 'volume': '9', 'author': 'Chen', 'year': '2023', 'journal-title': 'Heliyon'}, { 'issue': '2', 'key': '10.1016/j.eclinm.2024.102468_bib6', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/jmv.28441', 'article-title': 'Efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for COVID-19: ' 'a rapid review and meta-analysis', 'volume': '95', 'author': 'Amani', 'year': '2023', 'journal-title': 'J\xa0Med Virol'}, { 'issue': '15', 'key': '10.1016/j.eclinm.2024.102468_bib7', 'doi-asserted-by': 'crossref', 'first-page': '1397', 'DOI': '10.1056/NEJMoa2118542', 'article-title': 'Oral nirmatrelvir for high-risk, nonhospitalized adults with covid-19', 'volume': '386', 'author': 'Hammond', 'year': '2022', 'journal-title': 'N\xa0Engl J Med'}, { 'key': '10.1016/j.eclinm.2024.102468_bib8', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.eclinm.2023.101981', 'article-title': 'Oral Azvudine for hospitalised patients with COVID-19 and pre-existing ' 'conditions: a retrospective cohort study', 'volume': '59', 'author': 'Sun', 'year': '2023', 'journal-title': 'EClinicalMedicine'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2024.102468_bib9', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/jmv.28756', 'article-title': 'Real-world effectiveness of Azvudine versus nirmatrelvir-ritonavir in ' 'hospitalized patients with COVID-19: a retrospective cohort study', 'volume': '95', 'author': 'Deng', 'year': '2023', 'journal-title': 'J\xa0Med Virol'}, { 'issue': '6', 'key': '10.1016/j.eclinm.2024.102468_bib10', 'first-page': 'e158', 'article-title': 'Antiviral effect of azvudine and nirmatrelvir-ritonavir among ' 'hospitalized patients with COVID-19', 'volume': '86', 'author': 'Gao', 'year': '2023', 'journal-title': 'J\xa0Infect'}, { 'issue': '9', 'key': '10.1016/j.eclinm.2024.102468_bib11', 'article-title': 'Nirmatrelvir combined with ritonavir for preventing and treating ' 'COVID-19', 'volume': '9', 'author': 'Reis', 'year': '2022', 'journal-title': 'Cochrane Database Syst Rev'}, { 'issue': '12', 'key': '10.1016/j.eclinm.2024.102468_bib12', 'doi-asserted-by': 'crossref', 'first-page': '1681', 'DOI': '10.1016/S1473-3099(22)00507-2', 'article-title': 'Real-world effectiveness of early molnupiravir or ' 'nirmatrelvir-ritonavir in hospitalised patients with COVID-19 without ' "supplemental oxygen requirement on admission during Hong Kong's omicron " 'BA.2 wave: a retrospective cohort study', 'volume': '22', 'author': 'Wong', 'year': '2022', 'journal-title': 'Lancet Infect Dis'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2024.102468_bib13', 'doi-asserted-by': 'crossref', 'first-page': '996', 'DOI': '10.1016/j.cell.2020.09.038', 'article-title': 'Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and ' 'associations with age and disease severity', 'volume': '183', 'author': 'Rydyznski Moderbacher', 'year': '2020', 'journal-title': 'Cell'}, { 'issue': '3', 'key': '10.1016/j.eclinm.2024.102468_bib14', 'first-page': '248', 'article-title': 'Characteristics and outcomes of US Veterans at least 65 years of age at ' 'high risk of severe SARS-CoV-2 infection with or without receipt of ' 'oral antiviral agents', 'volume': '86', 'author': 'Gentry', 'year': '2023', 'journal-title': 'J\xa0Infect'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2024.102468_bib15', 'doi-asserted-by': 'crossref', 'first-page': '505', 'DOI': '10.7326/M22-3057', 'article-title': 'Effectiveness of molnupiravir and nirmatrelvir-ritonavir in ' 'hospitalized patients with COVID-19 : a target trial emulation study', 'volume': '176', 'author': 'Wan', 'year': '2023', 'journal-title': 'Ann Intern Med'}, { 'issue': '5', 'key': '10.1016/j.eclinm.2024.102468_bib16', 'doi-asserted-by': 'crossref', 'first-page': '585', 'DOI': '10.1007/s40265-022-01692-5', 'article-title': 'Nirmatrelvir plus ritonavir: first approval', 'volume': '82', 'author': 'Lamb', 'year': '2022', 'journal-title': 'Drugs'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2024.102468_bib17', 'doi-asserted-by': 'crossref', 'first-page': '133', 'DOI': '10.7326/M22-3427', 'article-title': 'Nirmatrelvir plus ritonavir for ambulatory COVID-19: expanding ' 'evidence, expanding role', 'volume': '176', 'author': 'Anesi', 'year': '2023', 'journal-title': 'Ann Intern Med'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2024.102468_bib18', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/jmv.28750', 'article-title': 'Efficacy of nirmatrelvir and ritonavir for post-acute COVID-19 sequelae ' 'beyond 3 months of SARS-CoV-2 infection', 'volume': '95', 'author': 'Chuang', 'year': '2023', 'journal-title': 'J\xa0Med Virol'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2024.102468_bib19', 'doi-asserted-by': 'crossref', 'first-page': '723', 'DOI': '10.1007/s11739-014-1124-1', 'article-title': 'Multimorbidity and polypharmacy in the elderly: lessons from REPOSI', 'volume': '9', 'author': 'Mannucci', 'year': '2014', 'journal-title': 'Internal Emerg Med'}, { 'key': '10.1016/j.eclinm.2024.102468_bib20', 'doi-asserted-by': 'crossref', 'first-page': '6053', 'DOI': '10.2147/IDR.S423725', 'article-title': 'Efficacy of nirmatrelvir-ritonavir versus azvudine for COVID-19 ' 'treatment in Tibet: a retrospective study', 'volume': '16', 'author': 'Zhao', 'year': '2023', 'journal-title': 'Infect Drug Resist'}, { 'key': '10.1016/j.eclinm.2024.102468_bib21', 'doi-asserted-by': 'crossref', 'first-page': 'm1443', 'DOI': '10.1136/bmj.m1443', 'article-title': 'Viral load dynamics and disease severity in patients infected with ' 'SARS-CoV-2 in Zhejiang province, China, January-March 2020: ' 'retrospective cohort study', 'volume': '369', 'author': 'Zheng', 'year': '2020', 'journal-title': 'BMJ'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2024.102468_bib22', 'doi-asserted-by': 'crossref', 'DOI': '10.1001/jamanetworkopen.2021.42796', 'article-title': 'Trajectory of viral RNA load among persons with incident SARS-CoV-2 ' 'G614 infection (wuhan strain) in association with COVID-19 symptom ' 'onset and severity', 'volume': '5', 'author': 'Stankiewicz Karita', 'year': '2022', 'journal-title': 'JAMA Netw Open'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2024.102468_bib23', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/microorganisms11071859', 'article-title': 'Composite interventions on outcomes of severely and critically ill ' 'patients with COVID-19 in Shanghai, China', 'volume': '11', 'author': 'Shao', 'year': '2023', 'journal-title': 'Microorganisms'}, { 'key': '10.1016/j.eclinm.2024.102468_bib24', 'article-title': 'Efficacy and safety of Paxlovid in severe adult patients with ' 'SARS-Cov-2 infection: a multicenter randomized controlled study', 'volume': '33', 'author': 'Liu', 'year': '2023', 'journal-title': 'Lancet Reg Health West Pac'}], 'container-title': 'eClinicalMedicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2589537024000476?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2589537024000476?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 3, 18]], 'date-time': '2024-03-18T09:15:51Z', 'timestamp': 1710753351000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2589537024000476'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 3]]}, 'references-count': 24, 'alternative-id': ['S2589537024000476'], 'URL': 'http://dx.doi.org/10.1016/j.eclinm.2024.102468', 'relation': {}, 'ISSN': ['2589-5370'], 'subject': ['General Medicine'], 'container-title-short': 'eClinicalMedicine', 'published': {'date-parts': [[2024, 3]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Antiviral effectiveness and survival correlation of azvudine and ' 'nirmatrelvir/ritonavir in elderly severe patients with COVID-19: a ' 'retrospective real-world study', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'eClinicalMedicine', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.eclinm.2024.102468', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2024 The Author(s). Published by Elsevier Ltd.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '102468'}