Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel: An Open-Label, Blank-Controlled Study — Hohhot City, Inner Mongolia Autonomous Region, China, 2022

DOI record: { "DOI": "10.46234/ccdcw2023.040", "ISSN": [ "2096-7071" ], "URL": "http://dx.doi.org/10.46234/ccdcw2023.040", "author": [ { "affiliation": [], "family": "Si", "given": "Shujie", "sequence": "first" }, { "affiliation": [], "name": "Pharmacy Department, Inner Mongolia Fourth Hospital, Hohhot City, Inner Mongolia Autonomous Region, China", "sequence": "first" }, { "affiliation": [], "family": "Jin", "given": "Canrui", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Jianping", "sequence": "additional" }, { "affiliation": [], "family": "Cao", "given": "Yunlong", "sequence": "additional" }, { "affiliation": [], "family": "Kan", "given": "Biao", "sequence": "additional" }, { "affiliation": [], "family": "Xue", "given": "Feng", "sequence": "additional" }, { "affiliation": [], "family": "Sunney Xie", "given": "Xiaoliang", "sequence": "additional" }, { "affiliation": [], "family": "Fang", "given": "Liang", "sequence": "additional" }, { "affiliation": [], "family": "Zeng", "given": "Gang", "sequence": "additional" }, { "affiliation": [], "family": "Zhang", "given": "Shuo", "sequence": "additional" }, { "affiliation": [], "family": "Hu", "given": "Yaling", "sequence": "additional" }, { "affiliation": [], "family": "Dong", "given": "Xiaoping", "sequence": "additional" }, { "affiliation": [], "name": "Clinical Research and Development Department, Sinovac Biotech Co., Ltd., Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "Changping Laboratory, Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "State Key Laboratory for Infectious Disease Prevention and Control, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "Research and Development Department, Sinovac Life Sciences Co., Ltd., Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "Inner Mongolia Blood Center, Hohhot City, Inner Mongolia Autonomous Region, China", "sequence": "additional" }, { "affiliation": [], "name": "Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan City, Hubei Province, China", "sequence": "additional" }, { "affiliation": [], "name": "China Academy of Chinese Medical Sciences, Beijing, China", "sequence": "additional" }, { "affiliation": [], "name": "Shanghai Institute of Infectious Diseases and Biosafety, Shanghai, China", "sequence": "additional" } ], "container-title": "China CDC Weekly", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2023, 3, 10 ] ], "date-time": "2023-03-10T14:19:05Z", "timestamp": 1678457945000 }, "deposited": { "date-parts": [ [ 2023, 3, 10 ] ], "date-time": "2023-03-10T14:19:11Z", "timestamp": 1678457951000 }, "indexed": { "date-parts": [ [ 2025, 5, 13 ] ], "date-time": "2025-05-13T13:10:12Z", "timestamp": 1747141812915, "version": "3.37.3" }, "is-referenced-by-count": 5, "issue": "10", "issued": { "date-parts": [ [ 2023 ] ] }, "journal-issue": { "issue": "10", "published-print": { "date-parts": [ [ 2023 ] ] } }, "language": "en", "link": [ { "URL": "https://weekly.chinacdc.cn/en/article/pdf/preview/10.46234/ccdcw2023.040", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "25413", "original-title": [], "page": "218-222", "prefix": "10.46234", "published": { "date-parts": [ [ 2023 ] ] }, "published-print": { "date-parts": [ [ 2023 ] ] }, "publisher": "Chinese Center for Disease Control and Prevention", "reference": [ { "DOI": "10.1111/joim.13372", "doi-asserted-by": "crossref", "key": "1", "unstructured": "Castro Dopico X, Ols S, Loré K, Karlsson Hedestam GB. Immunity to SARS-CoV-2 induced by infection or vaccination. J Intern Med 2022;291(1):32 − 50. http://dx.doi.org/10.1111/joim.13372." }, { "DOI": "10.1038/s41586-022-04980-y", "doi-asserted-by": "crossref", "key": "2", "unstructured": "Cao YL, Yisimayi A, Jian FC, Song WL, Xiao TH, Wang L, et al. BA. 2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 2022;608(7923):593 − 602. http://dx.doi.org/10.1038/s41586-022-04980-y." }, { "DOI": "10.1038/s41586-021-04385-3", "doi-asserted-by": "crossref", "key": "3", "unstructured": "Cao YL, Wang J, Jian FC, Xiao TH, Song WL, Yisimayi A, et al. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature 2022;602(7898):657 − 63. http://dx.doi.org/10.1038/s41586-021-04385-3." }, { "DOI": "10.1016/j.cell.2020.05.025", "doi-asserted-by": "crossref", "key": "4", "unstructured": "Cao YL, Su B, Guo XH, Sun WJ, Deng YQ, Bao LL, et al. Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells. Cell 2020;182(1):73 − 84.e16. http://dx.doi.org/10.1016/j.cell.2020.05.025." }, { "DOI": "10.1016/j.celrep.2022.111845", "doi-asserted-by": "crossref", "key": "5", "unstructured": "Cao YL, Jian FC, Zhang ZY, Yisimayi A, Hao XH, Bao LL, et al. Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep 2022;41(12):111845. http://dx.doi.org/10.1016/j.celrep.2022.111845." }, { "DOI": "10.1016/j.cell.2020.09.035", "doi-asserted-by": "crossref", "key": "6", "unstructured": "Du S, Cao YL, Zhu QY, Yu P, Qi FF, Wang GP, et al. Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 2020;183(4):1013 − 23.e13. http://dx.doi.org/10.1016/j.cell.2020.09.035." }, { "DOI": "10.1016/S0140-6736(22)00462-7", "doi-asserted-by": "crossref", "key": "7", "unstructured": "Nyberg T, Ferguson NM, Nash SG, Webster HH, Flaxman S, Andrews N, et al. Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B. 1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet 2022;399(10332):1303 − 12. http://dx.doi.org/10.1016/S0140-6736(22)00462-7." }, { "DOI": "10.1016/S0140-6736(22)01656-7", "doi-asserted-by": "crossref", "key": "8", "unstructured": "Agrawal U, Bedston S, McCowan C, Oke J, Patterson L, Robertson C, et al. Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. Lancet 2022;400(10360):1305 − 20. http://dx.doi.org/10.1016/S0140-6736(22)01656-7." }, { "DOI": "10.1016/S1473-3099(22)00345-0", "doi-asserted-by": "crossref", "key": "9", "unstructured": "McMenamin ME, Nealon J, Lin Y, Wong JY, Cheung JK, Lau EHY, et al. Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study. Lancet Infect Dis 2022;22(10):1435 − 43. http://dx.doi.org/10.1016/S1473-3099(22)00345-0." } ], "reference-count": 9, "references-count": 9, "relation": {}, "resource": { "primary": { "URL": "https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2023.040" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel: An Open-Label, Blank-Controlled Study — Hohhot City, Inner Mongolia Autonomous Region, China, 2022", "type": "journal-article", "volume": "5" }