Molnupiravir, a ribonucleoside antiviral prodrug against SARS-CoV-2, alters the voltage-gated sodium current and causes adverse events
et al., Virology, doi:10.1016/j.virol.2023.109865, Aug 2023
In vitro study showing that molnupiravir inhibited sodium channel currents by altering channel gating kinetics, which may explain some of the neurological and gastrointestinal side effects.
Potential risks of molnupiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-15. Multiple analyses have identified variants potentially created by molnupiravir16-20.
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Shiau et al., 7 Aug 2023, peer-reviewed, 7 authors.
In vitro studies are an important part of preclinical research, however results may be very different in vivo.
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