DOI record:
{
"DOI": "10.1016/j.virol.2023.109865",
"ISSN": [
"0042-6822"
],
"URL": "http://dx.doi.org/10.1016/j.virol.2023.109865",
"alternative-id": [
"S0042682223001782"
],
"article-number": "109865",
"assertion": [
{
"label": "This article is maintained by",
"name": "publisher",
"value": "Elsevier"
},
{
"label": "Article Title",
"name": "articletitle",
"value": "Molnupiravir, a ribonucleoside antiviral prodrug against SARS-CoV-2, alters the voltage-gated sodium current and causes adverse events"
},
{
"label": "Journal Title",
"name": "journaltitle",
"value": "Virology"
},
{
"label": "CrossRef DOI link to publisher maintained version",
"name": "articlelink",
"value": "https://doi.org/10.1016/j.virol.2023.109865"
},
{
"label": "Content Type",
"name": "content_type",
"value": "article"
},
{
"label": "Copyright",
"name": "copyright",
"value": "© 2023 Elsevier Inc. All rights reserved."
}
],
"author": [
{
"affiliation": [],
"family": "Shiau",
"given": "Ai-Li",
"sequence": "first"
},
{
"affiliation": [],
"family": "Lee",
"given": "Kuan-Hsien",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Cho",
"given": "Hsin-Yen",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Chuang",
"given": "Tzu-Hsien",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Yu",
"given": "Meng-Cheng",
"sequence": "additional"
},
{
"ORCID": "http://orcid.org/0000-0001-7821-9406",
"affiliation": [],
"authenticated-orcid": false,
"family": "Wu",
"given": "Chao-Liang",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Wu",
"given": "Sheng-Nan",
"sequence": "additional"
}
],
"container-title": "Virology",
"container-title-short": "Virology",
"content-domain": {
"crossmark-restriction": true,
"domain": [
"clinicalkey.fr",
"clinicalkey.jp",
"clinicalkey.com.au",
"clinicalkey.es",
"clinicalkey.com",
"elsevier.com",
"sciencedirect.com"
]
},
"created": {
"date-parts": [
[
2023,
8,
8
]
],
"date-time": "2023-08-08T00:36:35Z",
"timestamp": 1691454995000
},
"deposited": {
"date-parts": [
[
2023,
8,
8
]
],
"date-time": "2023-08-08T00:36:59Z",
"timestamp": 1691455019000
},
"indexed": {
"date-parts": [
[
2023,
8,
8
]
],
"date-time": "2023-08-08T04:25:14Z",
"timestamp": 1691468714904
},
"is-referenced-by-count": 0,
"issued": {
"date-parts": [
[
2023,
8
]
]
},
"language": "en",
"license": [
{
"URL": "https://www.elsevier.com/tdm/userlicense/1.0/",
"content-version": "tdm",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
},
{
"URL": "https://doi.org/10.15223/policy-017",
"content-version": "stm-asf",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
},
{
"URL": "https://doi.org/10.15223/policy-037",
"content-version": "stm-asf",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
},
{
"URL": "https://doi.org/10.15223/policy-012",
"content-version": "stm-asf",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
},
{
"URL": "https://doi.org/10.15223/policy-029",
"content-version": "stm-asf",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
},
{
"URL": "https://doi.org/10.15223/policy-004",
"content-version": "stm-asf",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
8,
1
]
],
"date-time": "2023-08-01T00:00:00Z",
"timestamp": 1690848000000
}
}
],
"link": [
{
"URL": "https://api.elsevier.com/content/article/PII:S0042682223001782?httpAccept=text/xml",
"content-type": "text/xml",
"content-version": "vor",
"intended-application": "text-mining"
},
{
"URL": "https://api.elsevier.com/content/article/PII:S0042682223001782?httpAccept=text/plain",
"content-type": "text/plain",
"content-version": "vor",
"intended-application": "text-mining"
}
],
"member": "78",
"original-title": [],
"page": "109865",
"prefix": "10.1016",
"published": {
"date-parts": [
[
2023,
8
]
]
},
"published-print": {
"date-parts": [
[
2023,
8
]
]
},
"publisher": "Elsevier BV",
"reference": [
{
"DOI": "10.1523/JNEUROSCI.5204-05.2006",
"article-title": "Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons",
"author": "Akemann",
"doi-asserted-by": "crossref",
"first-page": "4602",
"issue": "17",
"journal-title": "J. Neurosci.",
"key": "10.1016/j.virol.2023.109865_bib1",
"volume": "26",
"year": "2006"
},
{
"DOI": "10.1177/1756283X11415892",
"article-title": "Targeting ion channels for the treatment of gastrointestinal motility disorders",
"author": "Beyder",
"doi-asserted-by": "crossref",
"first-page": "5",
"issue": "1",
"journal-title": "Therap Adv Gastroenterol",
"key": "10.1016/j.virol.2023.109865_bib2",
"volume": "5",
"year": "2012"
},
{
"DOI": "10.1053/j.gastro.2014.02.054",
"article-title": "Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome",
"author": "Beyder",
"doi-asserted-by": "crossref",
"first-page": "1659",
"issue": "7",
"journal-title": "Gastroenterology",
"key": "10.1016/j.virol.2023.109865_bib3",
"volume": "146",
"year": "2014"
},
{
"DOI": "10.1146/annurev-pharmtox-010818-021757",
"article-title": "Structure and pharmacology of voltage-gated sodium and calcium channels",
"author": "Catterall",
"doi-asserted-by": "crossref",
"first-page": "133",
"journal-title": "Annu. Rev. Pharmacol. Toxicol.",
"key": "10.1016/j.virol.2023.109865_bib4",
"volume": "60",
"year": "2020"
},
{
"DOI": "10.3389/fphar.2020.01091",
"article-title": "Evidence for the effectiveness of remdesivir (GS-5734), a nucleoside-analog anti-viral drug in the inhibition of Ik(M) or Ik(DR) and in the stimulation of IMEP",
"author": "Chang",
"doi-asserted-by": "crossref",
"first-page": "1091",
"journal-title": "Front. Pharmacol.",
"key": "10.1016/j.virol.2023.109865_bib5",
"volume": "11",
"year": "2020"
},
{
"DOI": "10.3390/biomedicines9050549",
"article-title": "Characterization of direct perturbations on voltage-gated sodium current by esaxerenone, a nonsteroidal mineralocorticoid receptor blocker",
"author": "Chang",
"doi-asserted-by": "crossref",
"issue": "5",
"journal-title": "Biomedicines",
"key": "10.1016/j.virol.2023.109865_bib6",
"volume": "9",
"year": "2021"
},
{
"DOI": "10.1254/jphs.09018FP",
"article-title": "Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells",
"author": "Chen",
"doi-asserted-by": "crossref",
"first-page": "295",
"issue": "3",
"journal-title": "J. Pharmacol. Sci.",
"key": "10.1016/j.virol.2023.109865_bib7",
"volume": "110",
"year": "2009"
},
{
"DOI": "10.1093/bja/aep107",
"article-title": "Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current",
"author": "Chen",
"doi-asserted-by": "crossref",
"first-page": "244",
"issue": "2",
"journal-title": "Br. J. Anaesth.",
"key": "10.1016/j.virol.2023.109865_bib8",
"volume": "103",
"year": "2009"
},
{
"DOI": "10.3390/biomedicines10030721",
"article-title": "Activation of voltage-gated Na(+) current by GV-58, a known activator of Ca(V) channels",
"author": "Cho",
"doi-asserted-by": "crossref",
"issue": "3",
"journal-title": "Biomedicines",
"key": "10.1016/j.virol.2023.109865_bib9",
"volume": "10",
"year": "2022"
},
{
"DOI": "10.3390/biomedicines10010086",
"article-title": "The evidence for sparsentan-mediated inhibition of I(Na) and I(K(erg)): possibly unlinked to its antagonism of angiotensin II or endothelin type a receptor",
"author": "Chuang",
"doi-asserted-by": "crossref",
"issue": "1",
"journal-title": "Biomedicines",
"key": "10.1016/j.virol.2023.109865_bib10",
"volume": "10",
"year": "2021"
},
{
"article-title": "Ionic mechanisms maintaining action potential conduction velocity at high firing frequencies in an unmyelinated axon",
"author": "Cross",
"issue": "10",
"journal-title": "Phys. Rep.",
"key": "10.1016/j.virol.2023.109865_bib11",
"volume": "4",
"year": "2016"
},
{
"DOI": "10.1016/j.lfs.2011.05.016",
"article-title": "Resurgent Na+ current: a new avenue to neuronal excitability control",
"author": "Cruz",
"doi-asserted-by": "crossref",
"first-page": "564",
"issue": "15–16",
"journal-title": "Life Sci.",
"key": "10.1016/j.virol.2023.109865_bib12",
"volume": "89",
"year": "2011"
},
{
"DOI": "10.1021/jm501981g",
"article-title": "Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications",
"author": "de Lera Ruiz",
"doi-asserted-by": "crossref",
"first-page": "7093",
"issue": "18",
"journal-title": "J. Med. Chem.",
"key": "10.1016/j.virol.2023.109865_bib13",
"volume": "58",
"year": "2015"
},
{
"DOI": "10.1002/jnr.24134",
"article-title": "Development of resurgent and persistent sodium currents in mesencephalic trigeminal neurons",
"author": "Enomoto",
"doi-asserted-by": "crossref",
"first-page": "305",
"issue": "2",
"journal-title": "J. Neurosci. Res.",
"key": "10.1016/j.virol.2023.109865_bib14",
"volume": "96",
"year": "2018"
},
{
"DOI": "10.1016/j.celrep.2021.108940",
"article-title": "Anti-viral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication",
"author": "Garcia",
"doi-asserted-by": "crossref",
"issue": "1",
"journal-title": "Cell Rep.",
"key": "10.1016/j.virol.2023.109865_bib15",
"volume": "35",
"year": "2021"
},
{
"DOI": "10.1016/j.neulet.2009.01.066",
"article-title": "mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons",
"author": "Hashimoto",
"doi-asserted-by": "crossref",
"first-page": "62",
"issue": "1",
"journal-title": "Neurosci. Lett.",
"key": "10.1016/j.virol.2023.109865_bib16",
"volume": "453",
"year": "2009"
},
{
"DOI": "10.1113/JP275083",
"article-title": "Resurgent sodium current promotes action potential firing in the avian auditory brainstem",
"author": "Hong",
"doi-asserted-by": "crossref",
"first-page": "423",
"issue": "3",
"journal-title": "J. Physiol.",
"key": "10.1016/j.virol.2023.109865_bib17",
"volume": "596",
"year": "2018"
},
{
"DOI": "10.3390/biomedicines10061318",
"article-title": "Inhibitory effectiveness in delayed-rectifier potassium current caused by vortioxetine, known to Be a novel antidepressant",
"author": "Hsiao",
"doi-asserted-by": "crossref",
"first-page": "1318",
"issue": "6",
"journal-title": "Biomedicines",
"key": "10.1016/j.virol.2023.109865_bib18",
"volume": "10",
"year": "2022"
},
{
"DOI": "10.1016/j.neuroscience.2014.12.026",
"article-title": "The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents",
"author": "Huang",
"doi-asserted-by": "crossref",
"first-page": "125",
"journal-title": "Neuroscience",
"key": "10.1016/j.virol.2023.109865_bib19",
"volume": "287",
"year": "2015"
},
{
"DOI": "10.3390/molecules26195795",
"article-title": "Discovery, development, and patent trends on molnupiravir: a prospective oral treatment for COVID-19",
"author": "Imran",
"doi-asserted-by": "crossref",
"issue": "19",
"journal-title": "Molecules",
"key": "10.1016/j.virol.2023.109865_bib20",
"volume": "26",
"year": "2021"
},
{
"DOI": "10.1056/NEJMoa2116044",
"article-title": "Molnupiravir for oral treatment of covid-19 in nonhospitalized patients",
"author": "Jayk Bernal",
"doi-asserted-by": "crossref",
"first-page": "509",
"issue": "6",
"journal-title": "N. Engl. J. Med.",
"key": "10.1016/j.virol.2023.109865_bib21",
"volume": "386",
"year": "2022"
},
{
"DOI": "10.2174/09298673113206660257",
"article-title": "Isoform selective voltage-gated sodium channel modulators and the therapy of pain",
"author": "Jukič",
"doi-asserted-by": "crossref",
"first-page": "164",
"issue": "2",
"journal-title": "Curr. Med. Chem.",
"key": "10.1016/j.virol.2023.109865_bib22",
"volume": "21",
"year": "2014"
},
{
"DOI": "10.1523/JNEUROSCI.17-17-06639.1997",
"article-title": "Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons",
"author": "Jung",
"doi-asserted-by": "crossref",
"first-page": "6639",
"issue": "17",
"journal-title": "J. Neurosci.",
"key": "10.1016/j.virol.2023.109865_bib23",
"volume": "17",
"year": "1997"
},
{
"DOI": "10.1038/s41594-021-00651-0",
"article-title": "Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis",
"author": "Kabinger",
"doi-asserted-by": "crossref",
"first-page": "740",
"issue": "9",
"journal-title": "Nat. Struct. Mol. Biol.",
"key": "10.1016/j.virol.2023.109865_bib24",
"volume": "28",
"year": "2021"
},
{
"DOI": "10.1124/mol.113.088492",
"article-title": "Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels",
"author": "Kahlig",
"doi-asserted-by": "crossref",
"first-page": "162",
"issue": "1",
"journal-title": "Mol. Pharmacol.",
"key": "10.1016/j.virol.2023.109865_bib25",
"volume": "85",
"year": "2014"
},
{
"DOI": "10.1523/JNEUROSCI.23-12-04899.2003",
"article-title": "The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study",
"author": "Khaliq",
"doi-asserted-by": "crossref",
"first-page": "4899",
"issue": "12",
"journal-title": "J. Neurosci.",
"key": "10.1016/j.virol.2023.109865_bib26",
"volume": "23",
"year": "2003"
},
{
"DOI": "10.1038/s41467-019-10280-3",
"article-title": "Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors",
"author": "Kirchdoerfer",
"doi-asserted-by": "crossref",
"first-page": "2342",
"issue": "1",
"journal-title": "Nat. Commun.",
"key": "10.1016/j.virol.2023.109865_bib27",
"volume": "10",
"year": "2019"
},
{
"DOI": "10.1113/jphysiol.2014.277582",
"article-title": "Resurgent current of voltage-gated Na(+) channels",
"author": "Lewis",
"doi-asserted-by": "crossref",
"first-page": "4825",
"issue": "22",
"journal-title": "J. Physiol.",
"key": "10.1016/j.virol.2023.109865_bib28",
"volume": "592",
"year": "2014"
},
{
"DOI": "10.1113/jphysiol.2006.106682",
"article-title": "Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: an electrophysiological and modelling study",
"author": "Magistretti",
"doi-asserted-by": "crossref",
"first-page": "83",
"issue": "Pt 1",
"journal-title": "J. Physiol.",
"key": "10.1016/j.virol.2023.109865_bib29",
"volume": "573",
"year": "2006"
},
{
"article-title": "Efficacy and safety of Molnupiravir in COVID-19 patients: a systematic review",
"author": "Mali",
"first-page": "1",
"journal-title": "Ir. J. Med. Sci.",
"key": "10.1016/j.virol.2023.109865_bib30",
"year": "2022"
},
{
"DOI": "10.3390/antiox10060979",
"article-title": "Electron donor-acceptor capacity of selected pharmaceuticals against COVID-19",
"author": "Martínez",
"doi-asserted-by": "crossref",
"issue": "6",
"journal-title": "Antioxidants",
"key": "10.1016/j.virol.2023.109865_bib31",
"volume": "10",
"year": "2021"
},
{
"DOI": "10.1016/j.jbc.2021.100867",
"article-title": "Decoding molnupiravir-induced mutagenesis in SARS-CoV-2",
"author": "Menéndez-Arias",
"doi-asserted-by": "crossref",
"issue": "1",
"journal-title": "J. Biol. Chem.",
"key": "10.1016/j.virol.2023.109865_bib32",
"volume": "297",
"year": "2021"
},
{
"DOI": "10.7554/eLife.54940",
"article-title": "Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing",
"author": "Navarro",
"doi-asserted-by": "crossref",
"journal-title": "Elife",
"key": "10.1016/j.virol.2023.109865_bib33",
"volume": "9",
"year": "2020"
},
{
"article-title": "Aconitine-induced modification of single sodium channels in neuroblastoma cell membrane",
"author": "Negulyaev Yu",
"first-page": "167",
"issue": "2",
"journal-title": "Gen. Physiol. Biophys.",
"key": "10.1016/j.virol.2023.109865_bib34",
"volume": "9",
"year": "1990"
},
{
"DOI": "10.1016/j.coviro.2021.06.003",
"article-title": "Developing a direct acting, orally available anti-viral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19",
"author": "Painter",
"doi-asserted-by": "crossref",
"first-page": "17",
"journal-title": "Curr Opin Virol",
"key": "10.1016/j.virol.2023.109865_bib35",
"volume": "50",
"year": "2021"
},
{
"DOI": "10.1128/AAC.02428-20",
"article-title": "Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral anti-viral agent with activity against SARS-CoV-2",
"author": "Painter",
"doi-asserted-by": "crossref",
"issue": "5",
"journal-title": "Antimicrob. Agents Chemother.",
"key": "10.1016/j.virol.2023.109865_bib36",
"volume": "65",
"year": "2021"
},
{
"DOI": "10.3389/fncel.2021.760610",
"article-title": "Resurgent sodium current in neurons of the cerebral cortex",
"author": "Quattrocolo",
"doi-asserted-by": "crossref",
"journal-title": "Front. Cell. Neurosci.",
"key": "10.1016/j.virol.2023.109865_bib37",
"volume": "15",
"year": "2021"
},
{
"DOI": "10.1038/nrn1430",
"article-title": "The neurobiology of antiepileptic drugs",
"author": "Rogawski",
"doi-asserted-by": "crossref",
"first-page": "553",
"issue": "7",
"journal-title": "Nat. Rev. Neurosci.",
"key": "10.1016/j.virol.2023.109865_bib38",
"volume": "5",
"year": "2004"
},
{
"DOI": "10.1016/j.dsx.2021.102329",
"article-title": "Molnupiravir in COVID-19: a systematic review of literature",
"author": "Singh",
"doi-asserted-by": "crossref",
"issue": "6",
"journal-title": "Diabetes Metabol. Syndr.",
"key": "10.1016/j.virol.2023.109865_bib39",
"volume": "15",
"year": "2021"
},
{
"DOI": "10.1016/j.toxlet.2018.01.002",
"article-title": "Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3)",
"author": "So",
"doi-asserted-by": "crossref",
"first-page": "104",
"journal-title": "Toxicol. Lett.",
"key": "10.1016/j.virol.2023.109865_bib40",
"volume": "285",
"year": "2018"
},
{
"DOI": "10.1159/000475436",
"article-title": "Synergistic inhibition of delayed rectifier K+ and voltage-gated Na+ currents by artemisinin in pituitary tumor (GH3) cells",
"author": "So",
"doi-asserted-by": "crossref",
"first-page": "2053",
"issue": "5",
"journal-title": "Cell. Physiol. Biochem.",
"key": "10.1016/j.virol.2023.109865_bib41",
"volume": "41",
"year": "2017"
},
{
"DOI": "10.1210/er.2010-0005",
"article-title": "Ion channels and signaling in the pituitary gland",
"author": "Stojilkov",
"doi-asserted-by": "crossref",
"first-page": "845",
"journal-title": "Endocr. Rev.",
"key": "10.1016/j.virol.2023.109865_bib42",
"volume": "31",
"year": "2010"
},
{
"DOI": "10.1016/j.molcel.2020.12.048",
"article-title": "A tamoxifen receptor within a voltage-gated sodium channel",
"author": "Sula",
"doi-asserted-by": "crossref",
"first-page": "1160",
"issue": "6",
"journal-title": "Mol. Cell",
"key": "10.1016/j.virol.2023.109865_bib43",
"volume": "81",
"year": "2021"
},
{
"DOI": "10.2119/molmed.2016.00131",
"article-title": "A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia",
"author": "Tanaka",
"doi-asserted-by": "crossref",
"first-page": "338",
"journal-title": "Mol. Med.",
"key": "10.1016/j.virol.2023.109865_bib44",
"volume": "22",
"year": "2016"
},
{
"DOI": "10.3748/wjg.v28.i3.275",
"article-title": "Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs",
"author": "Tarnawski",
"doi-asserted-by": "crossref",
"first-page": "275",
"issue": "3",
"journal-title": "World J. Gastroenterol.",
"key": "10.1016/j.virol.2023.109865_bib45",
"volume": "28",
"year": "2022"
},
{
"DOI": "10.3389/fimmu.2022.855496",
"article-title": "Molnupiravir and its anti-viral activity against COVID-19",
"author": "Tian",
"doi-asserted-by": "crossref",
"journal-title": "Front. Immunol.",
"key": "10.1016/j.virol.2023.109865_bib46",
"volume": "13",
"year": "2022"
},
{
"DOI": "10.1016/j.antiviral.2022.105252",
"article-title": "Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern",
"author": "Vangeel",
"doi-asserted-by": "crossref",
"journal-title": "Antivir. Res.",
"key": "10.1016/j.virol.2023.109865_bib47",
"volume": "198",
"year": "2022"
},
{
"DOI": "10.1371/journal.pcbi.1007154",
"article-title": "Resurgent Na+ current offers noise modulation in bursting neurons",
"author": "Venugopal",
"doi-asserted-by": "crossref",
"issue": "6",
"journal-title": "PLoS Comput. Biol.",
"key": "10.1016/j.virol.2023.109865_bib48",
"volume": "15",
"year": "2019"
},
{
"DOI": "10.3390/ijms23073845",
"article-title": "The evidence for effective inhibition of I(Na) produced by mirogabalin ((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid), a known blocker of Ca(V) channels",
"author": "Wu",
"doi-asserted-by": "crossref",
"issue": "7",
"journal-title": "Int. J. Mol. Sci.",
"key": "10.1016/j.virol.2023.109865_bib49",
"volume": "23",
"year": "2022"
},
{
"DOI": "10.1002/jcp.25788",
"article-title": "Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels",
"author": "Wu",
"doi-asserted-by": "crossref",
"first-page": "3409",
"issue": "12",
"journal-title": "J. Cell. Physiol.",
"key": "10.1016/j.virol.2023.109865_bib50",
"volume": "232",
"year": "2017"
},
{
"DOI": "10.3390/ijms22062956",
"article-title": "Editorial to the special issue \"electrophysiology",
"author": "Wu",
"doi-asserted-by": "crossref",
"issue": "6",
"journal-title": "Int. J. Mol. Sci.",
"key": "10.1016/j.virol.2023.109865_bib51",
"volume": "22",
"year": "2021"
},
{
"DOI": "10.1016/j.tox.2009.01.009",
"article-title": "Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons",
"author": "Wu",
"doi-asserted-by": "crossref",
"first-page": "70",
"issue": "1",
"journal-title": "Toxicology",
"key": "10.1016/j.virol.2023.109865_bib52",
"volume": "258",
"year": "2009"
},
{
"DOI": "10.1111/j.1748-1716.2012.02438.x",
"article-title": "Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells",
"author": "Wu",
"doi-asserted-by": "crossref",
"first-page": "120",
"issue": "2",
"journal-title": "Acta Physiol.",
"key": "10.1016/j.virol.2023.109865_bib53",
"volume": "206",
"year": "2012"
},
{
"article-title": "Molnupiravir, favipiravir and other anti-viral drugs with proposed potentials for management of COVID-19: a concern on antioxidant aspect",
"author": "Yasri",
"first-page": "1",
"issue": "1",
"journal-title": "Int J Biochem Mol Biol",
"key": "10.1016/j.virol.2023.109865_bib54",
"volume": "13",
"year": "2022"
},
{
"article-title": "Review on molnupiravir as a promising oral drug for the treatment of COVID-19",
"author": "Zarenezhad",
"first-page": "1",
"journal-title": "Med. Chem. Res.",
"key": "10.1016/j.virol.2023.109865_bib55",
"year": "2022"
},
{
"DOI": "10.1038/s41467-021-26521-3",
"article-title": "Resurgent Na(+) currents promote ultrafast spiking in projection neurons that drive fine motor control",
"author": "Zemel",
"doi-asserted-by": "crossref",
"first-page": "6762",
"issue": "1",
"journal-title": "Nat. Commun.",
"key": "10.1016/j.virol.2023.109865_bib56",
"volume": "12",
"year": "2021"
},
{
"DOI": "10.1038/s41392-021-00837-4",
"article-title": "A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastrophe",
"author": "Zhao",
"doi-asserted-by": "crossref",
"first-page": "410",
"issue": "1",
"journal-title": "Signal Transduct. Targeted Ther.",
"key": "10.1016/j.virol.2023.109865_bib57",
"volume": "6",
"year": "2021"
}
],
"reference-count": 57,
"references-count": 57,
"relation": {},
"resource": {
"primary": {
"URL": "https://linkinghub.elsevier.com/retrieve/pii/S0042682223001782"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [
"Virology"
],
"subtitle": [],
"title": "Molnupiravir, a ribonucleoside antiviral prodrug against SARS-CoV-2, alters the voltage-gated sodium current and causes adverse events",
"type": "journal-article",
"update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy"
}