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All Studies   Meta Analysis    Recent:   

Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?

Saponaro et al., Frontiers in Immunology, doi:10.3389/fimmu.2021.745713
Jan 2022  
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ARDS 36% Improvement Relative Risk Vitamin D for COVID-19  Saponaro et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 93 patients in Italy (March - May 2020) Lower ARDS with higher vitamin D levels (not stat. sig., p=0.43) c19early.org Saponaro et al., Frontiers in Immunology, Jan 2022 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 93 COVID-19 pneumonia patients in Italy, showing low vitamin D levels associated with severe ARDS, and significantly lower vitamin D levels for non-survivors.
This is the 115th of 199 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
risk of ARDS, 36.5% lower, RR 0.64, p = 0.43, high D levels (≥20ng/ml) 5 of 32 (15.6%), low D levels (<20ng/ml) 15 of 61 (24.6%), NNT 11, severe ARDS.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saponaro et al., 24 Jan 2022, retrospective, Italy, peer-reviewed, 13 authors, study period March 2020 - May 2020.
This PaperVitamin DAll
Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?
Federica Saponaro, Maria Franzini, Chukwuma Okoye, Rachele Antognoli, Beatrice Campi, Marco Scalese, Tommaso Neri, Laura Carrozzi, Fabio Monzani, Riccardo Zucchi, Alessandro Celi, Aldo Paolicchi, Alessandro Saba
Frontiers in Immunology, doi:10.3389/fimmu.2021.745713
Background: Hypovitaminosis D has been suggested to play a possible role in coronavirus disease 2019 (COVID-19) infection. Methods: The aim of this study is to analyze the relationship between vitamin D status and a biochemical panel of inflammatory markers in a cohort of patients with COVID-19. A secondary endpoint was to evaluate the correlation between 25OHD levels and the severity of the disease. Ninety-three consecutive patients with COVID-19-related pneumonia were evaluated from March to May 2020 in two hospital units in Pisa, in whom biochemical inflammatory markers, 25OHD levels, P/F ratio at nadir during hospitalization, and complete clinical data were available. Results: Sixty-five percent of patients presented hypovitaminosis D (25OHD ≤ 20 ng/ml) and showed significantly higher IL
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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A secondary endpoint was to ' 'evaluate the correlation between 25OHD levels and the severity of the disease. Ninety-three ' 'consecutive patients with COVID-19-related pneumonia were evaluated from March to May 2020 in ' 'two hospital units in Pisa, in whom biochemical inflammatory markers, 25OHD levels, P/F ratio ' 'at nadir during hospitalization, and complete clinical data were ' 'available.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Sixty-five ' 'percent of patients presented hypovitaminosis D (25OHD ≤ 20 ng/ml) and showed significantly ' 'higher IL-6 [20.8 (10.9–45.6) vs. 12.9 (8.7–21.1) pg/ml, <jats:italic>p</jats:italic> = ' '0.02], CRP [10.7 (4.2–19.2) vs. 5.9 (1.6–8.1) mg/dl, <jats:italic>p</jats:italic> = 0.003], ' 'TNF-α [8.9 (6.0–14.8) vs. 4.4 (1.5–10.6) pg/ml, <jats:italic>p</jats:italic> = 0.01], D-dimer ' '[0.53 (0.25–0.72) vs. 0.22 (0.17–0.35) mg/l, <jats:italic>p</jats:italic> = 0.002], and IL-10 ' '[3.7 (1.8–6.9) vs. 2.3 (0.5–5.8) pg/ml, <jats:italic>p</jats:italic> = 0.03]. A significant ' 'inverse correlation was found between 25OHD and all these markers, even adjusted for age and ' 'sex. Hypovitaminosis D was prevalent in patients with severe ARDS, compared with the other ' 'groups (75% vs. 68% vs. 55%, <jats:italic>p</jats:italic> &amp;lt; 0.001), and 25OHD levels ' 'were lower in non-survivor ' 'patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The ' 'relationship between 25OHD levels and inflammatory markers suggests that vitamin D status ' 'needs to be taken into account in the management of these patients. 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Expert Panel', 'volume': '72', 'author': 'Ulivieri', 'year': '2021', 'journal-title': 'Endocrine'}], 'container-title': ['Frontiers in Immunology'], 'original-title': [], 'link': [ { 'URL': 'https://www.frontiersin.org/articles/10.3389/fimmu.2021.745713/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 1, 24]], 'date-time': '2022-01-24T06:12:25Z', 'timestamp': 1643004745000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 1, 24]]}, 'references-count': 60, 'alternative-id': ['10.3389/fimmu.2021.745713'], 'URL': 'http://dx.doi.org/10.3389/fimmu.2021.745713', 'relation': {}, 'ISSN': ['1664-3224'], 'issn-type': [{'value': '1664-3224', 'type': 'electronic'}], 'subject': ['Immunology', 'Immunology and Allergy'], 'published': {'date-parts': [[2022, 1, 24]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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