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0 0.5 1 1.5 2+ Mortality -168% Improvement Relative Risk Favipiravir for COVID-19  Saito et al.  LATE TREATMENT Is late treatment with favipiravir beneficial for COVID-19? Retrospective 132 patients in Japan (February 2020 - June 2021) Higher mortality with favipiravir (not stat. sig., p=0.063) c19early.org Saito et al., Infection Prevention in .., Jan 2024 Favors favipiravir Favors control

Predictors of in-hospital mortality in elderly unvaccinated patients during SARS-CoV-2 Alpha variants epidemic

Saito et al., Infection Prevention in Practice, doi:10.1016/j.infpip.2024.100341
Jan 2024  
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Retrospective 132 hospitalized COVID-19 patients over age 65 in Japan during the Alpha variant surge, showing higher mortality with favipiravir in unadjusted results, without statistical significance.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 168.3% higher, RR 2.68, p = 0.06, treatment 7 of 40 (17.5%), control 6 of 92 (6.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saito et al., 28 Jan 2024, retrospective, Japan, peer-reviewed, 6 authors, study period February 2020 - June 2021, average treatment delay 6.9 days. Contact: zyst_0404@yahoo.co.jp.
This PaperFavipiravirAll
Predictors of in-hospital mortality in elderly unvaccinated patients during SARS-CoV-2 Alpha variants epidemic
Zenya Saito, Shota Uchiyama, Saiko Nishioka, Kentaro Tamura, Nobumasa Tamura, Kazuyoshi Kuwano
Infection Prevention in Practice, doi:10.1016/j.infpip.2024.100341
Background: COVID-19, caused by SARS-CoV-2, has caused a global pandemic. This study aimed to identify predictors of in-hospital mortality in unvaccinated elderly patients with COVID-19 by comparing various predictive factors between the survivors and nonsurvivors. Methods: We retrospectively selected 132 unvaccinated patients aged over 65 years with COVID-19 at a hospital in Kanagawa, Japan, during SARS-CoV-2 Alpha variants epidemic. We compared the clinical characteristics, laboratory and radiological findings, treatment, and complications of the survivors and non-survivors. In logistic regression analysis, variables that were significant in the univariate analysis were subjected to multivariate analysis using the variable increase method. Results: There were 119 and 13 patients in the survivor and non-survivor groups, respectively. Multivariate regression revealed increasing odds with the presence of ARDS and DIC (odd ratio (OR) ¼ 16.35, 34.36; P¼0.002, 0.001, respectively) and prolonged hospital stay (OR ¼ 1.17; P¼0.004). Conclusions: We found the complications of ARDS and DIC and hospital length of stay to be independent predictors of in-hospital mortality in elderly unvaccinated patients with COVID-19. Establishing treatments and prevention methods for ARDS and DIC could result in lower mortality rates.
Credit author statement Zenya Saito: Conceptualization, Original draft, Writing, Reviewing and Editing. Shota Uchiyama: Data collection, investigation, reviewing final manuscript. Saiko Nishioka: Data collection, investigation, reviewing final manuscript. Kentaro Tamura: Data collection, investigation, reviewing final manuscript. Nobumasa Tamura: Data collection, investigation, reviewing final manuscript. Kazuyoshi Kuwano: Validation, Methodology, Data analysis, Supervision. Conflict of interest statement The authors declare that they have no competing interests.
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Late treatment
is less effective
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