An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection
Antimo Luigi Rosa, Antimo Cutone, Maria Pia Conte, Elena Campione, Luca Bianchi, Piera Valenti
BioMetals, doi:10.1007/s10534-022-00427-z
SARS-CoV-2. In vivo, Lf oral administration in early stage of SARS-CoV-2 infection counteracts COVID-19 pathogenesis. In particular, the effect of Lf on SARS-CoV-2 entry, inflammatory homeostasis, iron dysregulation, iron-proteins synthesis, reactive oxygen formation, oxidative stress, gut-lung axis regulation as well as on RNA negativization, and coagulation/fibrinolysis balance will be critically reviewed. Moreover, the molecular mechanisms underneath, including the Lf binding to HSPGs and spike glycoprotein, will be disclosed and discussed. Taken together, present data not only support the application of the oral administration of Lf alone in asymptomatic COVID-19 patients or as adjuvant of standard of care practice in symptomatic ones but also constitute the basis for enriching the limited literature on Lf effectiveness for COVID-19 treatment.
Keywords Lactoferrin • SARS-CoV-2 • COVID-19 • Inflammatory and iron homeostasis • Gut-lung axis • Coagulation and fibrinolysis
Lactoferrin and iron Lactoferrin (Lf), identified in 1939 in bovine milk and isolated in 1960 from both human (Johansson 1960; Montreuil et al. 1960 ) and bovine milk (Groves 1960), is constitutively synthesized by exocrine glands and secreted in human fluids. After induction,
Author contributions P.V.: conceptualization; L.R., A.C., and P.V.: writing: original
Declarations
Conflict of interest The authors declare no conflict of interest. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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'C (2021) Gut and airway microbiota and their role in COVID-19 infection '
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'Protective influence of lactoferrin on mice infected with the '
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'(1999) Inhibition of poliovirus type 1 infection by iron-, manganese- '
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'Y, Wang W, Wan P, Zhang J, Chen W, Lei Z, Chen X, Luo Z, Zhang Q, Xu M, '
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'C, Donatelli I, Superti F (2010) Bovine lactoferrin inhibits influenza A '
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'involvement of metal saturation and carbohydrates in the inhibition of '
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'characterization of sheep lactoferrin, an inhibitor of platelet '
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'T (2012) Nemeth E (2012) Hepcidin-induced endocytosis of ferroportin is '
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'natural glycoprotein involved in iron and inflammatory homeostasis. Int '
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'protein a exhibit distinct binding specificity to F protein and '
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