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An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection

Rosa et al., BioMetals, doi:10.1007/s10534-022-00427-z

Aug 2022

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Review of the antiviral activity of lactoferrin and efficacy for SARS-CoV-2.

Reviews covering lactoferrin for COVID-19 include1-6.

Important missing comments or errors? Let us know.

1. Eker et al., The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases, Frontiers in Immunology, doi:10.3389/fimmu.2024.1402135.frontiersin.org, doi.org.

2. Manzoni et al., Lactoferrin Supplementation in Preventing and Protecting from SARS-CoV-2 Infection: Is There Any Role in General and Special Populations? An Updated Review of Literature, International Journal of Molecular Sciences, doi:10.3390/ijms251910248.mdpi.com, doi.org.

3. Rosa et al., An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection, BioMetals, doi:10.1007/s10534-022-00427-z.springer.com, doi.org.

4. Mattar et al., Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity?, PeerJ, doi:10.7717/peerj.11303.peerj.com, doi.org.

5. Chang et al., Lactoferrin as potential preventative and adjunct treatment for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106118.sciencedirect.com, doi.org.

6. Campione et al., Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation, International Journal of Molecular Sciences, doi:10.3390/ijms21144903.mdpi.com, doi.org.

Rosa et al., 3 Aug 2022, peer-reviewed, 6 authors. Contact: piera.valenti@uniroma1.it.

This Paper Lactoferrin All

An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection

Antimo Luigi Rosa, Antimo Cutone, Maria Pia Conte, Elena Campione, Luca Bianchi, Piera Valenti

BioMetals, doi:10.1007/s10534-022-00427-z

SARS-CoV-2. In vivo, Lf oral administration in early stage of SARS-CoV-2 infection counteracts COVID-19 pathogenesis. In particular, the effect of Lf on SARS-CoV-2 entry, inflammatory homeostasis, iron dysregulation, iron-proteins synthesis, reactive oxygen formation, oxidative stress, gut-lung axis regulation as well as on RNA negativization, and coagulation/fibrinolysis balance will be critically reviewed. Moreover, the molecular mechanisms underneath, including the Lf binding to HSPGs and spike glycoprotein, will be disclosed and discussed. Taken together, present data not only support the application of the oral administration of Lf alone in asymptomatic COVID-19 patients or as adjuvant of standard of care practice in symptomatic ones but also constitute the basis for enriching the limited literature on Lf effectiveness for COVID-19 treatment. Keywords Lactoferrin • SARS-CoV-2 • COVID-19 • Inflammatory and iron homeostasis • Gut-lung axis • Coagulation and fibrinolysis Lactoferrin and iron Lactoferrin (Lf), identified in 1939 in bovine milk and isolated in 1960 from both human (Johansson 1960; Montreuil et al. 1960 ) and bovine milk (Groves 1960), is constitutively synthesized by exocrine glands and secreted in human fluids. After induction,

Author contributions P.V.: conceptualization; L.R., A.C., and P.V.: writing: original Declarations Conflict of interest The authors declare no conflict of interest. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

References

Abobaker, Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?, Eur J Clin Pharmacol, doi:10.1007/s00228-020-02942-9

Actor, Hwang, Kruzel, Lactoferrin as a natural immune modulator, Curr Pharm Des, doi:10.2174/138161209788453202

Al-Samkari, Leaf, Dzik, Carlson, Fogerty et al., COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection, Blood, doi:10.1182/blood.2020006520

Algahtani, Elabbasy, Samak, Adeboye, Yusuf et al., The Prospect of lactoferrin use as adjunctive agent in management of SARS-CoV-2 patients: a randomized pilot study, Medicina (kaunas), doi:10.3390/medicina57080842

Ali, Hasan, Kow, Merchant, Lactoferrin reduces the risk of respiratory tract infections: a meta-analysis of randomized controlled trials, Clin Nutr ESPEN, doi:10.1016/j.clnesp.2021.08.019

Ammendolia, Agamennone, Pietrantoni, Lannutti, Siciliano et al., Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus, Pathog Glob Health, doi:10.1179/2047773212Y.0000000004

Andrews, Disorders of iron metabolism, N Engl J Med, doi:10.1056/NEJM199912233412607

Baker, Baker, Lactoferrin and iron: structural and dynamic aspects of binding and release, Biometals, doi:10.1023/b:biom.0000027694.40260.70

Bartley, Zhou, Kuchel, Weinstock, Haynes, Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses, Front Immunol, doi:10.3389/fimmu.2017.01164

Bektas, Schurman, Sen, Ferrucci, Aging, inflammation and the environment, Exp Gerontol, doi:10.1016/j.exger.2017.12.015

Berlutti, Pantanella, Natalizi, Frioni, Paesano et al., Antiviral properties of lactoferrin-a natural immunity molecule, Molecules, doi:10.3390/molecules16086992

Bluard-Deconinck, Masson, Osinski, Heremans, Amino acid sequence of cysteic peptides of lactoferrin and demonstration of similarities between lactoferrin and transferrin, Biochim Biophys Acta, doi:10.1016/0005-2795(74)90002-6

Broz, Dixit, Inflammasomes: mechanism of assembly, regulation and signalling, Nat Rev Immunol, doi:10.1038/nri.2016.58

Budden, Gellatly, Wood, Cooper, Morrison et al., Emerging pathogenic links between microbiota and the gut-lung axis, Nat Rev Microbiol, doi:10.1038/nrmicro.2016.142

Campione, Cosio, Rosa, Lanna, Girolamo et al., Lactoferrin as protective natural barrier of respiratory and intestinal mucosa against coronavirus infection and inflammation, Int J Mol Sci, doi:10.3390/ijms21144903

Campione, Lanna, Cosio, Rosa, Conte et al., Lactoferrin against SARS-CoV-2 in vitro and in silico evidences, Front Pharmacol, doi:10.3389/fphar.2021.666600

Campione, Lanna, Cosio, Rosa, Conte et al., Lactoferrin as antiviral treatment in COVID-19 management: preliminary evidence, Int J Environ Res Public Health, doi:10.3390/ijerph182010985

Chang, Ng, Sun, Lactoferrin as potential preventative and adjunct treatment for COVID-19, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2020.106118

Cheng, Li, Li, Liu, Yan et al., Ferritin in the coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, J Clin Lab Anal, doi:10.1002/jcla.23618

Coffey, Ganz, Iron homeostasis-an anthropocentric perspective, J Biol Chem, doi:10.1074/jbc.R117.781823

Cui, Chen, Li, Liu, Wang, Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia, J Thromb Haemost, doi:10.1111/jth.14830

Cutone, Frioni, Berlutti, Valenti, Musci et al., Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages, Biometals, doi:10.1007/s10534-014-9742-7

Cutone, Lepanto, Rosa, Scotti, Rossi et al., Aerosolized bovine lactoferrin counteracts infection, inflammation and iron dysbalance in a cystic fibrosis mouse model of Pseudomonas aeruginosa chronic lung infection, Int J Mol Sci, doi:10.3390/ijms20092128

Cutone, Rosa, Lepanto, Scotti, Berlutti et al., Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages, Front Immunol, doi:10.3389/fimmu.2017.00705

Dai, Pan, Li, Liu, Zhang et al., The antimicrobial cathelicidin peptide hlF(1-11) attenuates alveolar macrophage pyroptosis induced by Acinetobacter baumannii in vivo, Exp Cell Res, doi:10.1016/j.yexcr.2018.01.035

Dai, Teng, Wu, The Antiviral roles of hydrogen sulfide by blocking the interaction between SARS-CoV-2 and its potential cell surface receptors, Oxid Med Cell Longev, doi:10.1155/2021/7866992

Denani, Real-Hohn, De Carvalho, Gomes, Gonçalves, Lactoferrin affects rhinovirus B-14 entry into H1-HeLa cells, Arch Virol, doi:10.1007/s00705-021-04993-4

Deriu, Boxx, He, Pan, Benavidez et al., Influenza virus affects intestinal microbiota and secondary Salmonella infection in the gut through Type I Interferons, PloS Pathog, doi:10.1371/journal.ppat.1005572

Di, Cutone, Polticelli, Rosa, Lepanto et al., The ferroportinceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin, Biometals, doi:10.1007/s10534-018-0087-5

Donovan, Lima, Pinkus, Pinkus, Zon et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis, Cell Metab, doi:10.1016/j.cmet.2005.01.003

Drakesmith, Prentice, Viral infection and iron metabolism, Nat Rev Microbiol, doi:10.1038/nrmicro1930

Ehsani, COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein, Biol Direct, doi:10.1186/s13062-020-00275-2

Enaud, Prevel, Ciarlo, Beaufils, Wieërs et al., The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks, Front Cell Infect Microbiol, doi:10.3389/fcimb.2020.00009

Fda, GRN 000465 Cow's Milk-Derived Lactoferrin

Fernandez-Musoles, Salom, Martínez-Maqueda, López-Díez, Recio et al., Antihypertensive effects of lactoferrin hydrolyzates: inhibition of angiotensin-and endothelin-converting enzymes, Food Chem, doi:10.1016/j.foodchem.2012.12.049

Figueroa-Lozano, Valk-Weeber, Van Leeuwen, Dijkhuizen, De Vos, Dietary N-Glycans from bovine lactoferrin and TLR modulation, Mol Nutr Food Res, doi:10.1002/mnfr.201700389

Fox, Akmatbekov, Harbert, Li, Brown et al., Pulmonary and cardiac pathology in African American patients with COVID-19: an Vol.: (0123456789) autopsy series from New Orleans, Lancet Respir Med, doi:10.1016/S2213-2600(20)30243-5

Frazer, Anderson, The orchestration of body iron intake: How and where do enterocytes receive their cues?, Blood Cells Mol Dis, doi:10.1016/s1079-9796(03)00039-1

Frioni, Conte, Cutone, Longhi, Musci et al., Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases, Biometals, doi:10.1007/s10534-014-9740-9

Fujihara, Hayashi, Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea, Arch Virol, doi:10.1007/BF01322673

Furlund, Kristoffersen, Devold, Vegarud, Jonassen, Bovine lactoferrin digested with human gastrointestinal enzymes inhibits replication of human echovirus 5 in cell culture, Nutr Res, doi:10.1016/j.nutres.2012.06.006

Furmanski, Li, Fortuna, Swamy, Das, Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity, J Exp Med, doi:10.1084/jem.170.2.415

Giobbe, Bonfante, Jones, Gagliano, Luni et al., SARS-CoV-2 infection and replication in human gastric organoids, Nat Commun, doi:10.1038/s41467-021-26762-2

Grier, Mcdavid, Wang, Qiu, Java et al., Neonatal gut and respiratory microbiota: coordinated development through time and space, Microbiome, doi:10.1186/s40168-018-0566-5

Groot, Geijtenbeek, Sanders, Baldwin, Sanchez-Hernandez et al., Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN-gp120 interaction, J Virol, doi:10.1128/JVI.79.5.3009-3015.2005

Groves, Cuthbertson, James, Moffatt, Cox et al., Respiratory disease following viral lung infection alters the murine gut microbiota, Front Immunol, doi:10.3389/fimmu.2018.00182

Groves, The isolation of a red protein from milk, J Am Chem Soc

Gualdi, Mertz, Gomez, Ramilo, Wittke et al., Lack of effect of bovine lactoferrin in respiratory syncytial virus replication and clinical disease severity in the mouse model, Antiviral Res, doi:10.1016/j.antiviral.2013.05.013

Hanada, Pirzadeh, Carver, Deng, Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia, Front Immunol, doi:10.3389/fimmu.2018.02640

Hartenian, Nandakumar, Ly, Tucker, Glaunsinger, The molecular virology of coronaviruses, J Biol Chem, doi:10.1074/jbc.REV120.013930

Hatmal, Alshaer, Al-Hatamleh, Hatmal, Smadi et al., Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2, Cells, doi:10.3390/cells9122638

Hirashima, Orito, Ohba, Kondo, Sakamoto et al., A randomized controlled trial of consensus interferon with or without lactoferrin for chronic hepatitis C patients with genotype 1b and high viral load, Hepatol Res, doi:10.1016/j.hepres.2004.01.002

Hu, Meng, Zhang, Xiang, Wang, The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor, Emerg Microbes Infect, doi:10.1080/22221751.2021.1888660

Hunter, Fulton, Ganz, Vogel, The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis, J Biol Chem, doi:10.1074/jbc.M205305200

Hussain, Cher, Abid, Abid, Role of gut microbiome in COVID-19: an insight into pathogenesis and therapeutic potential, Front Immunol, doi:10.3389/fimmu.2021.765965

Ichinohe, Pang, Kumamoto, Peaper, Ho et al., Microbiota regulates immune defense against respiratory tract Influenza A virus infection, Proc Natl Acad Sci U S A, doi:10.1073/pnas.1019378108

Ishibashi, Takeda, Tsukidate, Miyazaki, Ohira et al., Randomized placebo-controlled trial of interferon alpha-2b plus ribavirin with and without lactoferrin for chronic hepatitis C, Hepatol Res, doi:10.1016/j.hepres.2005.03.018

Johansson, Isolation of an iron-containing red protein from human milk, Acta Chem Scand

Kalashnyk, Petrova, Lykhmus, Mikhalovska, Mikhalovsky et al., Expression, function and cooperating partners of protease-activated receptor type 3 in vascular endothelial cells and B lymphocytes studied with specific monoclonal antibody, Mol Immunol, doi:10.1016/j.molimm.2012.12.021

Ke, Oton, Qu, Cortese, Zila et al., Structures and distributions of SARS-CoV-2 spike proteins on intact virions, Nature, doi:10.1038/s41586-020-2665-2

Kell, Heyden, Pretorius, The Biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria, Front Immunol, doi:10.3389/fimmu.2020.01221

Klok, Kruip, Van Der Meer, Arbous, Gommers et al., Incidence of thrombotic complications in critically ill ICU patients with COVID-19, Thromb Res, doi:10.1016/j.thromres.2020.04.013

Krause, Neitz, Magert, Schulz, Forssmann et al., LEAP-1, a novel highly disulfidebonded human peptide, exhibits antimicrobial activity, FEBS Lett, doi:10.1016/s0014-5793(00)01920-7

Kruzel, Actor, Boldogh, Zimecki, Lactoferrin in health and disease, Postepy Hig Med Dosw

Kruzel, Zimecki, Actor, Lactoferrin in a context of inflammation-induced pathology, Front Immunol, doi:10.3389/fimmu.2017.01438

Kuhara, Yamauchi, Tamura, Okamura, Oral administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type I IFN in the small intestine, J Interferon Cytokine Res, doi:10.1089/jir.2006.26.489

Lang, Yang, Deng, Liu, Yang et al., Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans, PLoS ONE, doi:10.1371/journal.pone.0023710

Latz, Xiao, Stutz, Activation and regulation of the inflammasomes, Nat Rev Immunol, doi:10.1038/nri3452

Lee, Peng, Gelbart, Wang, Beutler, Regulation of hepcidin transcription by interleukin-1 and interleukin-6, Proc Natl Acad Sci, doi:10.1073/pnas.0409808102

Legrand, Elass, Carpentier, Mazurier, Lactoferrin: a modulator of immune and inflammatory responses, Cell Mol Life Sci, doi:10.1007/s00018-005-5370-2

Legrand, Mazurier, A critical review of the roles of host lactoferrin in immunity, Biometals, doi:10.1007/s10534-010-9297-1

Lepanto, Rosa, Cutone, Conte, Paesano et al., Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study, Front Immunol, doi:10.3389/fimmu.2018.02123

Leveugle, Mazurier, Legrand, Mazurier, Montreuil et al., Lactotransferrin binding to its platelet receptor inhibits platelet aggregation, Eur J Biochem, doi:10.1111/j.1432-1033.1993.tb17871.x

Lin, Chu, Chiu, Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro, J Infect Dis, doi:10.1086/343809

Liu, Philippou, Kolokotroni, Siakallis, Rahima et al., Gut and airway microbiota and their role in COVID-19 infection and pathogenesis: a scoping review, Infection, doi:10.1007/s15010-021-01715-5

Longstaff, Kolev, Basic mechanisms and regulation of fibrinolysis, J Thromb Haemost, doi:10.1111/jth.12935

Lu, Hangoc, Oliff, Chen, Shen et al., Protective influence of lactoferrin on mice infected with the polycythemia-inducing strain of Friend virus complex, Cancer Res

Mancinelli, Rosa, Cutone, Lepanto, Franchitto et al., Viral hepatitis and iron dysregulation: molecular pathways and the role of lactoferrin, Molecules, doi:10.3390/molecules25081997

Mangan, Olhava, Roush, Seidel, Glick et al., Targeting the NLRP3 inflammasome in inflammatory diseases, Nat Rev Drug Discov, doi:10.1038/nrd.2018.149

Marchetti, Ammendolia, Superti, Glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin, Biochimie, doi:10.1016/j.biochi.2008.04.015

Marchetti, Longhi, Conte, Pisani, Valenti et al., Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells, Antiviral Res, doi:10.1016/0166-3542(95)00840-3

Marchetti, Pisani, Antonini, Valenti, Seganti et al., Metal complexes of bovine lactoferrin inhibit in vitro replication of herpes simplex virus type 1 and 2, Biometals, doi:10.1023/a:1009217709851

Marchetti, Superti, Ammendolia, Rossi, Valenti et al., Inhibition of poliovirus type 1 infection by iron-, manganese-and zinc-saturated lactoferrin, Med Microbiol Immunol, doi:10.1007/s004300050093

Miller, Iron deficiency anemia: A common and curable disease, Cold Spring Harb Perspect Med, doi:10.1101/cshperspect.a011866

Miotto, Rienzo, Bò, Boffi, Ruocco et al., Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin, Front Mol Biosci, doi:10.3389/fmolb.2021.607443

Mirabelli, Wotring, Zhang, Mccarty, Fursmidt et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proc Natl Acad Sci U S A, doi:10.1073/pnas.2105815118

Montreuil, Tonnelat, Mullet, Preparation and properties of lactosiderophilin (lactotransferrin) of human milk, Biochim Biophys Acta

Motoki, Mizuki, Tsukahara, Miyakawa, Kubo et al., Effects of lactoferrin-fortified formula on acute gastrointestinal symptoms in children aged 12-32 months: a randomized, double-blind, Placebo-Controlled Trial Front Pediatr, doi:10.3389/fped.2020.00233

Nai, Lorè, Pagani, Lorenzo, Modica et al., Hepcidin levels predict Covid-19 severity and mortality in a cohort of hospitalized Italian patients, Am J Hematol, doi:10.1002/ajh.26027

Naidu, Clemens, Pressman, Zaigham, Davies et al., COVID-19 during pregnancy and postpartum, J Diet Suppl, doi:10.1080/19390211.2020.1834047

Nemeth, Rivera, Gabayan, Keller, Taudorf et al., IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin, J Clin Investig, doi:10.1172/JCI20945

Ng, Cheung, Wong, Wang, Ip et al., Antiviral activities of whey proteins, Appl Microbiol Biotechnol, doi:10.1007/s00253-015-6818-4

Oda, Wakabayashi, Tanaka, Yamauchi, Sugita et al., Effects of lactoferrin on infectious diseases in Japanese summer: a randomized, double-blinded, placebo-controlled trial, J Microbiol Immunol Infect, doi:10.1016/j.jmii.2020.02.010

Okada, Tanaka, Sato, Ueno, Saito et al., Dose-response trial of lactoferrin in patients with chronic hepatitis C, Jpn J Cancer Res, doi:10.1111/j.1349-7006.2002.tb02484.x

Paesano, Berlutti, Pietropaoli, Goolsbee, Pacifici et al., Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non-pregnant women, Int J Immunopathol Pharmacol, doi:10.1177/039463201002300220

Paesano, Natalizi, Berlutti, Valenti, Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries, Pathog Glob Health, doi:10.1179/2047773212Y.0000000043

Pan, Shen, Yu, Ge, Chen et al., SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation, J Biol Chem, doi:10.1074/jbc.M008922200

Pan, Zhang, Liu, Wang, Lao et al., Dengue virus M protein promotes NLRP3 Inflammasome activation to induce vascular leakage in mice, J Virol, doi:10.1128/JVI.00996-19

Perricone, Bartoloni, Bursi, Cafaro, Guidelli et al., COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy, Immunol Res, doi:10.1007/s12026-020-09145-5

Pietrantoni, Ammendolia, Superti, Bovine lactoferrin: involvement of metal saturation and carbohydrates in the inhibition of influenza virus infection, Biochem Cell Biol, doi:10.1139/o11-072

Pietrantoni, Biase, Tinari, Marchetti, Valenti et al., Bovine lactoferrin inhibits adenovirus infection by interacting with viral structural polypeptides, Antimicrob Agents Chemother, doi:10.1128/AAC.47.8.2688-2691.2003

Pietrantoni, Dofrelli, Tinari, Ammendolia, Puzelli et al., Bovine lactoferrin inhibits influenza A virus induced programmed cell death in vitro, Biometals, doi:10.1007/s10534-010-9323-3

Puddu, Borghi, Gessani, Valenti, Belardelli et al., Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection, Int J Biochem Cell Biol, doi:10.1016/s1357-2725(98)00066-1

Puddu, Latorre, Carollo, Catizone, Ricci et al., Bovine lactoferrin counteracts toll-like receptor mediated activation signals in antigen presenting cells, PLoS ONE, doi:10.1371/journal.pone.0022504

Puddu, Valenti, Gessani, Immunomodulatory effects of lactoferrin on antigen presenting cells, Biochimie, doi:10.1016/j.biochi.2008.05.005

Pérez-Cano, Marín-Gallén, Castell, Rodríguez-Palmero, Rivero et al., Supplementing suckling rats with whey protein concentrate modulates the immune response and ameliorates rat rotavirus-induced diarrhea, Nutr, doi:10.3945/jn.108.093856

Qian, Jollès, Migliore-Samour, Fiat, Isolation and characterization of sheep lactoferrin, an inhibitor of platelet aggregation and comparison with human lactoferrin, Biochim Biophys Acta, doi:10.1016/0304-4165(94)00126-i

Qiao, Sugianto, Fung, Del-Castillo-Rueda, Moran-Jimenez et al., Hepcidin-induced endocytosis of ferroportin is dependent Vol:. (1234567890) on ferroportin ubiquitination, Cell Metab, doi:10.1016/j.cmet.2012.03.018

Rosa, Cutone, Lepanto, Paesano, Valenti, Lactoferrin: a natural glycoprotein involved in iron and inflammatory homeostasis, Int J Mol Sci, doi:10.3390/ijms18091985

Rosa, Tripepi, Naldi, Aimati, Santangeli et al., Ambulatory COVID-19 patients treated with lactoferrin as a supplementary antiviral agent: a preliminary study, J Clin Med, doi:10.3390/jcm10184276

Sano, Nagai, Tsutsumi, Kuroki, Lactoferrin and surfactant protein a exhibit distinct binding specificity to F protein and differently modulate respiratory syncytial virus infection, Eur J Immunol, doi:10.1002/eji.200324218

Serrano, Kochergina, Albors, Diaz, Oroval et al., Liposomal lactoferrin as potential preventative and cure for COVID-19, Int J Res Health Sci, doi:10.5530/ijrhs.8.1.3

Sherman, Pritzl, Xia, Miller, Zaghouani et al., Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice, Biochem Biophys Res Commun, doi:10.1016/j.bbrc.2015.10.067

Shimizu, Matsuzawa, Okada, Tazume, Dosako et al., Lactoferrinmediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity, Arch Virol, doi:10.1007/BF01718201

Shin, Wakabayashi, Yamauchi, Teraguchi, Tamura et al., Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice, J Med Microbiol, doi:10.1099/jmm.0.46018-0

Sienkiewicz, Jaśkiewicz, Tarasiuk, Fichna, Lactoferrin: an overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance, Crit Rev Food Sci Nutr, doi:10.1080/10408398.2021.1895063

Simpson, Aging and inflammation: directing traffic through physical activity, Brain Behav Immun, doi:10.1016/j.bbi.2016.05.015

Skendros, Mitsios, Chrysanthopoulou, Mastellos, Metallidis et al., Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis, J Clin Invest, doi:10.1172/JCI141374

Spik, Coddeville, Mazurier, Bourne, Cambillaut et al., Primary and three-dimensional structure of lactotransferrin (lactoferrin) glycans, Adv Exp Med Biol, doi:10.1007/978-1-4615-2548-6_3

Stefanescu, Hétu, Slaughter, Shea, Shetty, A pilot study of Biotene OralBalance® gel for oral care in mechanically ventilated preterm neonates, Contemp Clin Trials, doi:10.1016/j.cct.2013.03.010

Superti, Ammendolia, Valenti, Seganti, Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29, Med Microbiol Immunol, doi:10.1007/s004300050049

Superti, Lactoferrin from bovine milk: a protective companion for Life, Nutrients, doi:10.3390/nu12092562

Superti, Siciliano, Rega, Giansanti, Valenti et al., Involvement of bovine lactoferrin metal saturation, sialic acid and protein fragments in the inhibition of rotavirus infection, Biochim Biophys Acta, doi:10.1016/s0304-4165(01)00178-7

Swart, Kuipers, Smit, Pauwels, Debéthune et al., Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro, AIDS Res Hum Retroviruses, doi:10.1089/aid.1996.12.769

Szabo, Petrasek, Inflammasome activation and function in liver disease, Nat Rev Gastroenterol Hepatol, doi:10.1038/nrgastro.2015.94

Taha, Mehrez, Sitohy, Dawood, Hamid et al., Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1), Virol J, doi:10.1186/1743-422X-7-330

Tanaka, Ikeda, Nozaki, Kato, Tsuda et al., Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study, Jpn J Cancer Res, doi:10.1111/j.1349-7006.1999.tb00756.x

Tang, Yang, Duan, Liao, Liu et al., Transferrin receptor is another receptor for SARS-CoV-2 entry, bioRxiv, doi:10.1101/2020.10.23.350348

Tian, Hu, Niu, Liu, Xu et al., Pulmonary pathology of early-phase 2019 novel Coronavirus (COVID-19) Pneumonia in two patients with lung cancer, J Thorac Oncol, doi:10.1016/j.jtho.2020.02.010

Tinari, Pietrantoni, Ammendolia, Valenti, Superti, Inhibitory activity of bovine lactoferrin against echovirus induced programmed cell death in vitro, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2005.02.011

Toldo, Bussani, Nuzzi, Bonaventura, Mauro et al., Inflammasome formation in the lungs of patients with fatal COVID-19, Inflamm Res, doi:10.1007/s00011-020-01413-2

Ueno, Sato, Yamamoto, Tanaka, Ohkawa et al., Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic

Valenti, Antonini, Lactoferrin: an important host defence against microbial and viral attack, Cell Mol Life Sci, doi:10.1007/s00018-005-5372-0

Valenti, Rosa, Capobianco, Lepanto, Schiavi et al., Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense, Front Immunol, doi:10.3389/fimmu.2018.00376

Van Splunter, Perdijk, Fick-Brinkhof, Feitsma, Vollenbroek et al., Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: results from a nutritional intervention study with bovine lactoferrin, GOS Vitamin d Front Immunol, doi:10.3389/fimmu.2018.02677

Van Veen, Geerts, Van Berkel, Nuijens, The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis, Eur J Biochem, doi:10.1111/j.1432-1033.2003.03965.x

Verga Falzacappa, Spasic, Kessler, Stolte, Hentze et al., STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, Blood, doi:10.1182/blood-2006-07-033969

Vitetta, Coulson, Beck, Gramotnev, Du et al., The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: a double blind randomized study, Complement Ther Med, doi:10.1016/j.ctim.2012.12.006

Vlahakos, Marathias, Arkadopoulos, Vlahakos, Hyperferritinemia in patients with COVID-19: an opportunity for iron chelation?, Artif Organs, doi:10.1111/aor.13812

Wakabayashi, Kurokawa, Shin, Teraguchi, Tamura et al., Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice, Biosci Biotechnol Biochem, doi:10.1271/bbb.68.537

Wakabayashi, Oda, Yamauchi, Abe, Lactoferrin for prevention of common viral infections, J Infect Chemother, doi:10.1016/j.jiac.2014.08.003

Wan, Du, Hong, Chen, Que et al., Neurological complications and infection mechanism of SARS-COV-2, Signal Transduct Target Ther, doi:10.1038/s41392-021-00818-7

Wang, Jiang, Yan, Gong, Han et al., RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway, Nat Immunol, doi:10.1038/ni.3015

Wang, Li, Wei, Lian, Sun et al., Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation, J Exp Med, doi:10.1084/jem.20140625

Wang, Yue, Dang, Yang, Chen et al., Role of sialylated glycans on bovine lactoferrin against influenza virus, Glycoconjugate J, doi:10.1007/s10719-021-10029-5

Wang, Zhang, Wu, Niu, Song et al., Structural and functional basis of SARS-CoV-2 entry by using human ACE2, Cell, doi:10.1016/j.cell.2020.03.045

Welsh, Hwang, Boyd, Kruzel, Hunter et al., Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology, Tuberculosis, doi:10.1016/j.tube.2011.10.019

Wenzhong, Hualan, COVID-19: captures iron and generates reactive oxygen species to damage the human immune system, Autoimmunity, doi:10.1080/08916934.2021.1913581

Wisgrill, Wessely, Spittler, Förster-Waldl, Berger et al., Human lactoferrin attenuates the proinflammatory response of neonatal monocyte-derived macrophages, Clin Exp Immunol, doi:10.1111/cei.13108

Wrighting, Andrews, Interleukin-6 induces hepcidin expression through STAT3, Blood, doi:10.1182/blood-2006-06-027631

Wu, Guo, Tang, Hong, Zhou et al., Prolonged presence of SARS-CoV-2 viral RNA in faecal samples, Lancet Gastroenterol Hepatol, doi:10.1016/S2468-1253(20)30083-2

Wu, Monroe, Church, Characterization of the glycosaminoglycan-binding region of lactoferrin, Arch Biochem Biophys, doi:10.1006/abbi.1995.1139

Wu, Zhao, Yu, Chen, Song et al., A new coronavirus associated with human respiratory disease in China, Nature, doi:10.1038/s41586-020-2008-3

Xu, Fan, Liu, Cheng, Tu et al., Novel anticoagulant peptide from lactoferrin binding thrombin at the active site and Exosite-I, J Agric Food Chem, doi:10.1021/acs.jafc.9b08094

Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir Med, doi:10.1016/S2213-2600(20)30076-X

Yamamoto, Ura, Tanemura, Koyama, Takano et al., Inhibitory effect of bovine lactoferrin on human parainfluenza virus type 2 infection, J Health Sci, doi:10.1248/jhs.56.613

Yen, Chiu, Huang, Lin, Effects of lactoferrin-containing formula in the prevention of enterovirus and rotavirus infection and impact on serum cytokine levels: a randomized trial, Chang Gung Med J

Yi, Kaneko, Yu, Murakami, Hepatitis C virus envelope proteins bind lactoferrin, J Virol, doi:10.1128/JVI.71.8.5997-6002.1997

Yildiz, Mazel-Sanchez, Kandasamy, Manicassamy, Schmolke, Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis, Microbiome, doi:10.1186/s40168-017-0386-z

Zhu, Zhang, Li, Yang, Song et al., China Novel Coronavirus Investigating and Research Team (2020) A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med, doi:10.1056/NEJMoa2001017

Zimecki, Actor, Kruzel, The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm, Int Immunopharmacol, doi:10.1016/j.intimp.2021.107571

Zumerle, Mathieu, Delga, Heinis, Viatte et al., Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype, Blood, doi:10.1182/blood-2014-01-550467

Zuo, Warnock, Harbaugh, Yalavarthi, Gockman et al., Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients, Sci Rep, doi:10.1038/s41598-020-80010-z

Zwirzitz, Reiter, Skrabana, Ohradanova-Repic, Majdic et al., Lactoferrin is a natural inhibitor of plasminogen activation, J Biol Chem, doi:10.1074/jbc.RA118.003145

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' 'https://doi.org/10.5530/ijrhs.8.1.3', 'journal-title': 'Int J Res Health Sci'}, { 'issue': '4', 'key': '427_CR115', 'doi-asserted-by': 'publisher', 'first-page': '766', 'DOI': '10.1016/j.bbrc.2015.10.067', 'volume': '467', 'author': 'MP Sherman', 'year': '2015', 'unstructured': 'Sherman MP, Pritzl CJ, Xia C, Miller MM, Zaghouani H, Hahm B (2015) ' 'Lactoferrin acts as an adjuvant during influenza vaccination of neonatal ' 'mice. Biochem Biophys Res Commun 467(4):766–770. 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' 'https://doi.org/10.1007/BF01718201', 'journal-title': 'Arch Virol'}, { 'issue': 'Pt 8', 'key': '427_CR117', 'doi-asserted-by': 'publisher', 'first-page': '717', 'DOI': '10.1099/jmm.0.46018-0', 'volume': '54', 'author': 'K Shin', 'year': '2005', 'unstructured': 'Shin K, Wakabayashi H, Yamauchi K, Teraguchi S, Tamura Y, Kurokawa M, ' 'Shiraki K (2005) Effects of orally administered bovine lactoferrin and ' 'lactoperoxidase on influenza virus infection in mice. J Med Microbiol ' '54(Pt 8):717–723. https://doi.org/10.1099/jmm.0.46018-0', 'journal-title': 'J Med Microbiol'}, { 'key': '427_CR118', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1080/10408398.2021.1895063', 'volume': '8', 'author': 'M Sienkiewicz', 'year': '2021', 'unstructured': 'Sienkiewicz M, Jaśkiewicz A, Tarasiuk A, Fichna J (2021) Lactoferrin: an ' 'overview of its main functions, immunomodulatory and antimicrobial role, ' 'and clinical significance. Crit Rev Food Sci Nutr 8:1–18. ' 'https://doi.org/10.1080/10408398.2021.1895063', 'journal-title': 'Crit Rev Food Sci Nutr'}, { 'key': '427_CR119', 'doi-asserted-by': 'publisher', 'first-page': '10', 'DOI': '10.1016/j.bbi.2016.05.015', 'volume': '56', 'author': 'RJ Simpson', 'year': '2016', 'unstructured': 'Simpson RJ (2016) Aging and inflammation: directing traffic through ' 'physical activity. Brain Behav Immun 56:10–11. ' 'https://doi.org/10.1016/j.bbi.2016.05.015', 'journal-title': 'Brain Behav Immun'}, { 'issue': '11', 'key': '427_CR120', 'doi-asserted-by': 'publisher', 'first-page': '6151', 'DOI': '10.1172/JCI141374', 'volume': '130', 'author': 'P Skendros', 'year': '2020', 'unstructured': 'Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, ' 'Rafailidis P, Ntinopoulou M, Sertaridou E, Tsironidou V, Tsigalou C, ' 'Tektonidou M, Konstantinidis T, Papagoras C, Mitroulis I, Germanidis G, ' 'Lambris JD, Ritis K (2020) Complement and tissue factor-enriched ' 'neutrophil extracellular traps are key drivers in COVID-19 ' 'immunothrombosis. J Clin Invest 130(11):6151–6157. ' 'https://doi.org/10.1172/JCI141374', 'journal-title': 'J Clin Invest'}, { 'key': '427_CR121', 'doi-asserted-by': 'publisher', 'first-page': '21', 'DOI': '10.1007/978-1-4615-2548-6_3', 'volume': '357', 'author': 'G Spik', 'year': '1994', 'unstructured': 'Spik G, Coddeville B, Mazurier J, Bourne Y, Cambillaut C, Montreuil J ' '(1994) Primary and three-dimensional structure of lactotransferrin ' '(lactoferrin) glycans. Adv Exp Med Biol 357:21–32. ' 'https://doi.org/10.1007/978-1-4615-2548-6_3', 'journal-title': 'Adv Exp Med Biol'}, { 'issue': '2', 'key': '427_CR122', 'doi-asserted-by': 'publisher', 'first-page': '33', 'DOI': '10.1016/j.cct.2013.03.010', 'volume': '35', 'author': 'BM Stefanescu', 'year': '2013', 'unstructured': 'Stefanescu BM, Hétu C, Slaughter JC, O’Shea TM, Shetty AK (2013) A pilot ' 'study of Biotene OralBalance® gel for oral care in mechanically ' 'ventilated preterm neonates. Contemp Clin Trials 35(2):33–39. ' 'https://doi.org/10.1016/j.cct.2013.03.010', 'journal-title': 'Contemp Clin Trials'}, { 'issue': '9', 'key': '427_CR123', 'doi-asserted-by': 'publisher', 'first-page': '2562', 'DOI': '10.3390/nu12092562', 'volume': '12', 'author': 'F Superti', 'year': '2020', 'unstructured': 'Superti F (2020) Lactoferrin from bovine milk: a protective companion ' 'for Life. Nutrients 12(9):2562. https://doi.org/10.3390/nu12092562', 'journal-title': 'Nutrients'}, { 'issue': '2–3', 'key': '427_CR124', 'doi-asserted-by': 'publisher', 'first-page': '83', 'DOI': '10.1007/s004300050049', 'volume': '186', 'author': 'F Superti', 'year': '1997', 'unstructured': 'Superti F, Ammendolia MG, Valenti P, Seganti L (1997) Antirotaviral ' 'activity of milk proteins: lactoferrin prevents rotavirus infection in ' 'the enterocyte-like cell line HT-29. Med Microbiol Immunol ' '186(2–3):83–91. https://doi.org/10.1007/s004300050049', 'journal-title': 'Med Microbiol Immunol'}, { 'issue': '2–3', 'key': '427_CR125', 'doi-asserted-by': 'publisher', 'first-page': '107', 'DOI': '10.1016/s0304-4165(01)00178-7', 'volume': '1528', 'author': 'F Superti', 'year': '2001', 'unstructured': 'Superti F, Siciliano R, Rega B, Giansanti F, Valenti P, Antonini G ' '(2001) Involvement of bovine lactoferrin metal saturation, sialic acid ' 'and protein fragments in the inhibition of rotavirus infection. Biochim ' 'Biophys Acta 1528(2–3):107–115. ' 'https://doi.org/10.1016/s0304-4165(01)00178-7', 'journal-title': 'Biochim Biophys Acta'}, { 'issue': '9', 'key': '427_CR126', 'doi-asserted-by': 'publisher', 'first-page': '769', 'DOI': '10.1089/aid.1996.12.769', 'volume': '12', 'author': 'PJ Swart', 'year': '1996', 'unstructured': 'Swart PJ, Kuipers ME, Smit C, Pauwels R, deBéthune MP, de Clercq E, ' 'Meijer DK, Huisman JG (1996) Antiviral effects of milk proteins: ' 'acylation results in polyanionic compounds with potent activity against ' 'human immunodeficiency virus types 1 and 2 in vitro. AIDS Res Hum ' 'Retroviruses 12(9):769–775. https://doi.org/10.1089/aid.1996.12.769', 'journal-title': 'AIDS Res Hum Retroviruses'}, { 'issue': '7', 'key': '427_CR127', 'doi-asserted-by': 'publisher', 'first-page': '387', 'DOI': '10.1038/nrgastro.2015.94', 'volume': '12', 'author': 'G Szabo', 'year': '2015', 'unstructured': 'Szabo G, Petrasek J (2015) Inflammasome activation and function in liver ' 'disease. Nat Rev Gastroenterol Hepatol 12(7):387–400. ' 'https://doi.org/10.1038/nrgastro.2015.94', 'journal-title': 'Nat Rev Gastroenterol Hepatol'}, { 'key': '427_CR128', 'doi-asserted-by': 'publisher', 'first-page': '330', 'DOI': '10.1186/1743-422X-7-330', 'volume': '7', 'author': 'SH Taha', 'year': '2010', 'unstructured': 'Taha SH, Mehrez MA, Sitohy MZ, Abou Dawood AG, Abd-El Hamid MM, Kilany ' 'WH (2010) Effectiveness of esterified whey proteins fractions against ' 'Egyptian Lethal Avian Influenza A (H5N1). Virol J 7:330. ' 'https://doi.org/10.1186/1743-422X-7-330', 'journal-title': 'Virol J'}, { 'issue': '4', 'key': '427_CR129', 'doi-asserted-by': 'publisher', 'first-page': '367', 'DOI': '10.1111/j.1349-7006.1999.tb00756.x', 'volume': '90', 'author': 'K Tanaka', 'year': '1999', 'unstructured': 'Tanaka K, Ikeda M, Nozaki A, Kato N, Tsuda H, Saito S, Sekihara H (1999) ' 'Lactoferrin inhibits hepatitis C virus viremia in patients with chronic ' 'hepatitis C: a pilot study. Jpn J Cancer Res 90(4):367–371. ' 'https://doi.org/10.1111/j.1349-7006.1999.tb00756.x', 'journal-title': 'Jpn J Cancer Res'}, { 'key': '427_CR130', 'doi-asserted-by': 'publisher', 'author': 'X Tang', 'year': '2020', 'unstructured': 'Tang X, Yang M, Duan Z, Liao Z, Liu L, Cheng R, Fang M, Wang G, Liu H, ' 'Xu J, Kamau PM, Zhang Z, Yang L, Zhao X, Peng X, Lai R (2020) ' 'Transferrin receptor is another receptor for SARS-CoV-2 entry. bioRxiv. ' 'https://doi.org/10.1101/2020.10.23.350348', 'journal-title': 'bioRxiv', 'DOI': '10.1101/2020.10.23.350348'}, { 'issue': '5', 'key': '427_CR131', 'doi-asserted-by': 'publisher', 'first-page': '700', 'DOI': '10.1016/j.jtho.2020.02.010', 'volume': '15', 'author': 'S Tian', 'year': '2020', 'unstructured': 'Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY (2020) Pulmonary pathology of ' 'early-phase 2019 novel Coronavirus (COVID-19) Pneumonia in two patients ' 'with lung cancer. J Thorac Oncol 15(5):700–704. ' 'https://doi.org/10.1016/j.jtho.2020.02.010', 'journal-title': 'J Thorac Oncol'}, { 'issue': '5', 'key': '427_CR132', 'doi-asserted-by': 'publisher', 'first-page': '433', 'DOI': '10.1016/j.ijantimicag.2005.02.011', 'volume': '25', 'author': 'A Tinari', 'year': '2005', 'unstructured': 'Tinari A, Pietrantoni A, Ammendolia MG, Valenti P, Superti F (2005) ' 'Inhibitory activity of bovine lactoferrin against echovirus induced ' 'programmed cell death in vitro. Int J Antimicrob Agents 25(5):433–438. ' 'https://doi.org/10.1016/j.ijantimicag.2005.02.011', 'journal-title': 'Int J Antimicrob Agents'}, { 'issue': '1', 'key': '427_CR133', 'doi-asserted-by': 'publisher', 'first-page': '7', 'DOI': '10.1007/s00011-020-01413-2', 'volume': '70', 'author': 'S Toldo', 'year': '2021', 'unstructured': 'Toldo S, Bussani R, Nuzzi V, Bonaventura A, Mauro AG, Cannatà A, ' 'Pillappa R, Sinagra G, Nana-Sinkam P, Sime P, Abbate A (2021) ' 'Inflammasome formation in the lungs of patients with fatal COVID-19. ' 'Inflamm Res 70(1):7–10. https://doi.org/10.1007/s00011-020-01413-2', 'journal-title': 'Inflamm Res'}, { 'issue': '10', 'key': '427_CR134', 'doi-asserted-by': 'publisher', 'first-page': '1105', 'DOI': '10.1111/j.1349-7006.2006.00274.x', 'volume': '97', 'author': 'H Ueno', 'year': '2006', 'unstructured': 'Ueno H, Sato T, Yamamoto S, Tanaka K, Ohkawa S, Takagi H, Yokosuka O, ' 'Furuse J, Saito H, Sawaki A, Kasugai H, Osaki Y, Fujiyama S, Sato K, ' 'Wakabayashi K, Okusaka T (2006) Randomized, double-blind, ' 'placebo-controlled trial of bovine lactoferrin in patients with chronic ' 'hepatitis C. Cancer Sci 97(10):1105–1110. ' 'https://doi.org/10.1111/j.1349-7006.2006.00274.x', 'journal-title': 'Cancer Sci'}, { 'issue': '22', 'key': '427_CR135', 'doi-asserted-by': 'publisher', 'first-page': '2576', 'DOI': '10.1007/s00018-005-5372-0', 'volume': '62', 'author': 'P Valenti', 'year': '2005', 'unstructured': 'Valenti P, Antonini G (2005) Lactoferrin: an important host defence ' 'against microbial and viral attack. Cell Mol Life Sci 62(22):2576–2587. ' 'https://doi.org/10.1007/s00018-005-5372-0', 'journal-title': 'Cell Mol Life Sci'}, { 'key': '427_CR136', 'doi-asserted-by': 'publisher', 'first-page': '376', 'DOI': '10.3389/fimmu.2018.00376', 'volume': '9', 'author': 'P Valenti', 'year': '2018', 'unstructured': 'Valenti P, Rosa L, Capobianco D, Lepanto MS, Schiavi E, Cutone A, ' 'Paesano R, Mastromarino P (2018) Role of Lactobacilli and Lactoferrin in ' 'the Mucosal Cervicovaginal Defense. Front Immunol 9:376. ' 'https://doi.org/10.3389/fimmu.2018.00376', 'journal-title': 'Front Immunol'}, { 'key': '427_CR137', 'doi-asserted-by': 'publisher', 'first-page': '2677', 'DOI': '10.3389/fimmu.2018.02677', 'volume': '9', 'author': 'M van Splunter', 'year': '2018', 'unstructured': 'van Splunter M, Perdijk O, Fick-Brinkhof H, Feitsma AL, ' 'Floris-Vollenbroek EG, Meijer B, Brugman S, Savelkoul HFJ, van Hoffen E, ' 'van Neerven RJJ (2018) Bovine lactoferrin enhances TLR7-mediated ' 'responses in plasmacytoid dendritic cells in elderly women: results from ' 'a nutritional intervention study with bovine lactoferrin. GOS Vitamin d ' 'Front Immunol 9:2677. https://doi.org/10.3389/fimmu.2018.02677', 'journal-title': 'GOS Vitamin d Front Immunol'}, { 'issue': '4', 'key': '427_CR138', 'doi-asserted-by': 'publisher', 'first-page': '678', 'DOI': '10.1111/j.1432-1033.2003.03965.x', 'volume': '271', 'author': 'HA van Veen', 'year': '2004', 'unstructured': 'van Veen HA, Geerts ME, van Berkel PH, Nuijens JH (2004) The role of ' 'N-linked glycosylation in the protection of human and bovine lactoferrin ' 'against tryptic proteolysis. Eur J Biochem 271(4):678–684. ' 'https://doi.org/10.1111/j.1432-1033.2003.03965.x', 'journal-title': 'Eur J Biochem'}, { 'issue': '1', 'key': '427_CR139', 'doi-asserted-by': 'publisher', 'first-page': '353', 'DOI': '10.1182/blood-2006-07-033969', 'volume': '109', 'author': 'MV Verga Falzacappa', 'year': '2007', 'unstructured': 'Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, ' 'Muckenthaler MU (2007) STAT3 mediates hepatic hepcidin expression and ' 'its inflammatory stimulation. Blood 109(1):353–358. ' 'https://doi.org/10.1182/blood-2006-07-033969', 'journal-title': 'Blood'}, { 'issue': '3', 'key': '427_CR140', 'doi-asserted-by': 'publisher', 'first-page': '164', 'DOI': '10.1016/j.ctim.2012.12.006', 'volume': '21', 'author': 'L Vitetta', 'year': '2013', 'unstructured': 'Vitetta L, Coulson S, Beck SL, Gramotnev H, Du S, Lewis S (2013) The ' 'clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction ' '(Lf/IgF) for the common cold: a double blind randomized study. ' 'Complement Ther Med 21(3):164–171. ' 'https://doi.org/10.1016/j.ctim.2012.12.006', 'journal-title': 'Complement Ther Med'}, { 'issue': '2', 'key': '427_CR141', 'doi-asserted-by': 'publisher', 'first-page': '163', 'DOI': '10.1111/aor.13812', 'volume': '45', 'author': 'VD Vlahakos', 'year': '2021', 'unstructured': 'Vlahakos VD, Marathias KP, Arkadopoulos N, Vlahakos DV (2021) ' 'Hyperferritinemia in patients with COVID-19: an opportunity for iron ' 'chelation? Artif Organs 45(2):163–167. https://doi.org/10.1111/aor.13812', 'journal-title': 'Artif Organs'}, { 'issue': '3', 'key': '427_CR142', 'doi-asserted-by': 'publisher', 'first-page': '537', 'DOI': '10.1271/bbb.68.537', 'volume': '68', 'author': 'H Wakabayashi', 'year': '2004', 'unstructured': 'Wakabayashi H, Kurokawa M, Shin K, Teraguchi S, Tamura Y, Shiraki K ' '(2004) Oral lactoferrin prevents body weight loss and increases cytokine ' 'responses during herpes simplex virus type 1 infection of mice. Biosci ' 'Biotechnol Biochem 68(3):537–544. https://doi.org/10.1271/bbb.68.537', 'journal-title': 'Biosci Biotechnol Biochem'}, { 'key': '427_CR143', 'doi-asserted-by': 'publisher', 'first-page': '666', 'DOI': '10.1016/j.jiac.2014.08.003', 'volume': '20', 'author': 'H Wakabayashi', 'year': '2014', 'unstructured': 'Wakabayashi H, Oda H, Yamauchi K, Abe F (2014) Lactoferrin for ' 'prevention of common viral infections. J Infect Chemother 20:666–671. ' 'https://doi.org/10.1016/j.jiac.2014.08.003', 'journal-title': 'J Infect Chemother'}, { 'issue': '1', 'key': '427_CR144', 'doi-asserted-by': 'publisher', 'first-page': '406', 'DOI': '10.1038/s41392-021-00818-7', 'volume': '6', 'author': 'D Wan', 'year': '2021', 'unstructured': 'Wan D, Du T, Hong W, Chen L, Que H, Lu S, Peng X (2021) Neurological ' 'complications and infection mechanism of SARS-COV-2. Signal Transduct ' 'Target Ther 6(1):406. https://doi.org/10.1038/s41392-021-00818-7', 'journal-title': 'Signal Transduct Target Ther'}, { 'issue': '12', 'key': '427_CR145', 'doi-asserted-by': 'publisher', 'first-page': '2397', 'DOI': '10.1084/jem.20140625', 'volume': '211', 'author': 'J Wang', 'year': '2014', 'unstructured': 'Wang J, Li F, Wei H, Lian ZX, Sun R, Tian Z (2014a) Respiratory ' 'influenza virus infection induces intestinal immune injury via ' 'microbiota-mediated Th17 cell-dependent inflammation. J Exp Med ' '211(12):2397–2410. https://doi.org/10.1084/jem.20140625', 'journal-title': 'J Exp Med'}, { 'issue': '12', 'key': '427_CR146', 'doi-asserted-by': 'publisher', 'first-page': '1126', 'DOI': '10.1038/ni.3015', 'volume': '15', 'author': 'X Wang', 'year': '2014', 'unstructured': 'Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R (2014b) RNA ' 'viruses promote activation of the NLRP3 inflammasome through a ' 'RIP1-RIP3-DRP1 signaling pathway. Nat Immunol 15(12):1126–1133. ' 'https://doi.org/10.1038/ni.3015', 'journal-title': 'Nat Immunol'}, { 'issue': '4', 'key': '427_CR147', 'doi-asserted-by': 'publisher', 'first-page': '894', 'DOI': '10.1016/j.cell.2020.03.045', 'volume': '181', 'author': 'Q Wang', 'year': '2020', 'unstructured': 'Wang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen ' 'KY, Wang Q, Zhou H, Yan J, Qi J (2020) Structural and functional basis ' 'of SARS-CoV-2 entry by using human ACE2. Cell 181(4):894-904.e9. ' 'https://doi.org/10.1016/j.cell.2020.03.045', 'journal-title': 'Cell'}, { 'issue': '6', 'key': '427_CR148', 'doi-asserted-by': 'publisher', 'first-page': '689', 'DOI': '10.1007/s10719-021-10029-5', 'volume': '38', 'author': 'X Wang', 'year': '2021', 'unstructured': 'Wang X, Yue L, Dang L, Yang J, Chen Z, Wang X, Shu J, Li Z (2021) Role ' 'of sialylated glycans on bovine lactoferrin against influenza virus. ' 'Glycoconjugate J 38(6):689–696. ' 'https://doi.org/10.1007/s10719-021-10029-5', 'journal-title': 'Glycoconjugate J'}, { 'issue': 'Suppl 1', 'key': '427_CR149', 'doi-asserted-by': 'publisher', 'first-page': 'S105', 'DOI': '10.1016/j.tube.2011.10.019', 'volume': '91', 'author': 'KJ Welsh', 'year': '2011', 'unstructured': 'Welsh KJ, Hwang SA, Boyd S, Kruzel ML, Hunter RL, Actor JK (2011) ' 'Influence of oral lactoferrin on Mycobacterium tuberculosis induced ' 'immunopathology. Tuberculosis (edinb) 91(Suppl 1):S105-113. ' 'https://doi.org/10.1016/j.tube.2011.10.019', 'journal-title': 'Tuberculosis (edinb)'}, { 'issue': '4', 'key': '427_CR150', 'doi-asserted-by': 'publisher', 'first-page': '213', 'DOI': '10.1080/08916934.2021.1913581', 'volume': '54', 'author': 'L Wenzhong', 'year': '2021', 'unstructured': 'Wenzhong L, Hualan L (2021) COVID-19: captures iron and generates ' 'reactive oxygen species to damage the human immune system. 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' 'https://doi.org/10.1038/s41586-020-2008-3', 'journal-title': 'Nature'}, { 'issue': '5', 'key': '427_CR155', 'doi-asserted-by': 'publisher', 'first-page': '434', 'DOI': '10.1016/S2468-1253(20)30083-2', 'volume': '5', 'author': 'Y Wu', 'year': '2020', 'unstructured': 'Wu Y, Guo C, Tang L, Hong Z, Zhou J, Dong X, Yin H, Xiao Q, Tang Y, Qu ' 'X, Kuang L, Fang X, Mishra N, Lu J, Shan H, Jiang G, Huang X (2020b) ' 'Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet ' 'Gastroenterol Hepatol 5(5):434–435. ' 'https://doi.org/10.1016/S2468-1253(20)30083-2', 'journal-title': 'Lancet Gastroenterol Hepatol'}, { 'issue': '10', 'key': '427_CR156', 'doi-asserted-by': 'publisher', 'first-page': '3132', 'DOI': '10.1021/acs.jafc.9b08094', 'volume': '68', 'author': 'S Xu', 'year': '2020', 'unstructured': 'Xu S, Fan F, Liu H, Cheng S, Tu M, Du M (2020a) Novel anticoagulant ' 'peptide from lactoferrin binding thrombin at the active site and ' 'Exosite-I. J Agric Food Chem 68(10):3132–3139. ' 'https://doi.org/10.1021/acs.jafc.9b08094', 'journal-title': 'J Agric Food Chem'}, { 'issue': '4', 'key': '427_CR157', 'doi-asserted-by': 'publisher', 'first-page': '420', 'DOI': '10.1016/S2213-2600(20)30076-X', 'volume': '8', 'author': 'Z Xu', 'year': '2020', 'unstructured': 'Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, ' 'Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS ' '(2020b) Pathological findings of COVID-19 associated with acute ' 'respiratory distress syndrome. Lancet Respir Med 8(4):420–422. ' 'https://doi.org/10.1016/S2213-2600(20)30076-X', 'journal-title': 'Lancet Respir Med'}, { 'key': '427_CR158', 'doi-asserted-by': 'publisher', 'first-page': '613', 'DOI': '10.1248/jhs.56.613', 'volume': '54', 'author': 'H Yamamoto', 'year': '2010', 'unstructured': 'Yamamoto H, Ura Y, Tanemura M, Koyama A, Takano S, Uematsu J, Kawano M, ' 'Tsurudome M, O’Brien M, Komada H (2010) Inhibitory effect of bovine ' 'lactoferrin on human parainfluenza virus type 2 infection. J Health Sci ' '54:613–617. https://doi.org/10.1248/jhs.56.613', 'journal-title': 'J Health Sci'}, { 'issue': '4', 'key': '427_CR159', 'first-page': '395', 'volume': '34', 'author': 'MH Yen', 'year': '2011', 'unstructured': 'Yen MH, Chiu CH, Huang YC, Lin TY (2011) Effects of ' 'lactoferrin-containing formula in the prevention of enterovirus and ' 'rotavirus infection and impact on serum cytokine levels: a randomized ' 'trial. 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Sci Rep 11(1):1580. https://doi.org/10.1038/s41598-020-80010-z', 'journal-title': 'Sci Rep'}, { 'issue': '22', 'key': '427_CR166', 'doi-asserted-by': 'publisher', 'first-page': '8600', 'DOI': '10.1074/jbc.RA118.003145', 'volume': '293', 'author': 'A Zwirzitz', 'year': '2018', 'unstructured': 'Zwirzitz A, Reiter M, Skrabana R, Ohradanova-Repic A, Majdic O, Gutekova ' 'M, Cehlar O, Petrovčíková E, Kutejova E, Stanek G, Stockinger H, Leksa V ' '(2018) Lactoferrin is a natural inhibitor of plasminogen activation. 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