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'abstract': '<jats:p>The world population is still facing the second wave of the COVID-19 pandemic. Such a '
'challenge requires complicated tools to control, namely vaccines, effective cures, and '
'complementary agents. Here we present one candidate for the role of an effective cure and/or '
'complementary agent: lactoferrin. It is the cross-talking mediator between many '
'organs/cellular systems in the body. It serves as a physiological, immunological, and '
'anti-microbial barrier, and acts as a regulator molecule. Furthermore, lactoferrin has '
'receptors on most tissues cells, and is a rich source for bioactive peptides, particularly in '
'the digestive system. In the past months, in vitro and in vivo evidence has accumulated '
'regarding lactoferrin’s ability to control SARS-CoV-2 infectivity in different indicated '
'scenarios. Also, lactoferrin or whey milk (of human or other mammal’s origin) is a cheap, '
'easily available, and safe agent, the use of which can produce promising results. '
'Pharmaceutical and/or food supplementary formulas of lactoferrin could be particularly '
'effective in controlling the gastrointestinal COVID-19-associated symptoms and could limit '
'the fecal-oral viral infection transmission, through mechanisms that mimic that of norovirus '
'infection control by lactoferrin via induction of intestinal innate immunity. This natural '
'avenue may be effective not only in symptomatic patients, but could also be more helpful in '
'asymptomatic patients as a main or adjuvant treatment.</jats:p>',
'DOI': '10.7717/peerj.11303',
'type': 'journal-article',
'created': {'date-parts': [[2021, 4, 14]], 'date-time': '2021-04-14T07:31:23Z', 'timestamp': 1618385483000},
'page': 'e11303',
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'title': ['Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity?'],
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'author': [ { 'given': 'Ehab H.',
'family': 'Mattar',
'sequence': 'first',
'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King '
'Abdulaziz University, Jeddah, Saudi Arabia'}]},
{ 'given': 'Fatma',
'family': 'Elrashdy',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Endemic Medicine and Hepatogastroenterology, Cairo '
'University, Cairo, Egypt'}]},
{ 'given': 'Hussein A.',
'family': 'Almehdar',
'sequence': 'additional',
'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King '
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'given': 'Vladimir N.',
'family': 'Uversky',
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'affiliation': [ { 'name': 'Department of Molecular Medicine, University of South Florida, '
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'given': 'Elrashdy M.',
'family': 'Redwan',
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'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King '
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'General Neuroscience'],
'published': {'date-parts': [[2021, 4, 14]]},
'article-number': 'e11303'}
