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Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity?

Mattar et al., PeerJ, doi:10.7717/peerj.11303
Apr 2021  
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Review of the mechanisms of action and evidence for beneficial effects of lactoferrin for COVID-19.
Reviews covering lactoferrin for COVID-19 include1-4.
Mattar et al., 14 Apr 2021, peer-reviewed, 5 authors.
This PaperLactoferrinAll
{ 'indexed': { 'date-parts': [[2021, 12, 19]], 'date-time': '2021-12-19T09:45:11Z', 'timestamp': 1639907111786}, 'reference-count': 100, 'publisher': 'PeerJ', 'license': [ { 'start': { 'date-parts': [[2021, 4, 14]], 'date-time': '2021-04-14T00:00:00Z', 'timestamp': 1618358400000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': ''}], 'funder': [ { 'name': 'The Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia', 'award': ['838']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': [], 'abstract': '<jats:p>The world population is still facing the second wave of the COVID-19 pandemic. Such a ' 'challenge requires complicated tools to control, namely vaccines, effective cures, and ' 'complementary agents. Here we present one candidate for the role of an effective cure and/or ' 'complementary agent: lactoferrin. It is the cross-talking mediator between many ' 'organs/cellular systems in the body. It serves as a physiological, immunological, and ' 'anti-microbial barrier, and acts as a regulator molecule. Furthermore, lactoferrin has ' 'receptors on most tissues cells, and is a rich source for bioactive peptides, particularly in ' 'the digestive system. In the past months, in vitro and in vivo evidence has accumulated ' 'regarding lactoferrin’s ability to control SARS-CoV-2 infectivity in different indicated ' 'scenarios. Also, lactoferrin or whey milk (of human or other mammal’s origin) is a cheap, ' 'easily available, and safe agent, the use of which can produce promising results. ' 'Pharmaceutical and/or food supplementary formulas of lactoferrin could be particularly ' 'effective in controlling the gastrointestinal COVID-19-associated symptoms and could limit ' 'the fecal-oral viral infection transmission, through mechanisms that mimic that of norovirus ' 'infection control by lactoferrin via induction of intestinal innate immunity. This natural ' 'avenue may be effective not only in symptomatic patients, but could also be more helpful in ' 'asymptomatic patients as a main or adjuvant treatment.</jats:p>', 'DOI': '10.7717/peerj.11303', 'type': 'journal-article', 'created': {'date-parts': [[2021, 4, 14]], 'date-time': '2021-04-14T07:31:23Z', 'timestamp': 1618385483000}, 'page': 'e11303', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': ['Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity?'], 'prefix': '10.7717', 'volume': '9', 'author': [ { 'given': 'Ehab H.', 'family': 'Mattar', 'sequence': 'first', 'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King ' 'Abdulaziz University, Jeddah, Saudi Arabia'}]}, { 'given': 'Fatma', 'family': 'Elrashdy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Endemic Medicine and Hepatogastroenterology, Cairo ' 'University, Cairo, Egypt'}]}, { 'given': 'Hussein A.', 'family': 'Almehdar', 'sequence': 'additional', 'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King ' 'Abdulaziz University, Jeddah, Saudi Arabia'}]}, { 'ORCID': '', 'authenticated-orcid': True, 'given': 'Vladimir N.', 'family': 'Uversky', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Molecular Medicine, University of South Florida, ' 'Tampa, Florida, United States'}]}, { 'ORCID': '', 'authenticated-orcid': True, 'given': 'Elrashdy M.', 'family': 'Redwan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Biological Science Department, Faculty of Science, King ' 'Abdulaziz University, Jeddah, Saudi Arabia'}]}], 'member': '4443', 'published-online': {'date-parts': [[2021, 4, 14]]}, 'reference': [ { 'issue': '1', 'key': '10.7717/peerj.11303/ref-1', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1080/87559129.2012.692137', 'article-title': 'Bioactive peptides of buffalo, camel, goat, sheep mare, and yak milks ' 'and milk products', 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