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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Unresolved fever 25% Improvement Relative Risk Unresolved fatigue 33% Unresolved cough 0% Unresolved headache 0% Unresolved loss of smell.. 25% Lactoferrin  Algahtani et al.  LATE TREATMENT  RCT Is late treatment with lactoferrin beneficial for COVID-19? RCT 54 patients in Egypt (July - September 2020) Trial underpowered to detect differences Algahtani et al., Medicina, August 2021 Favors lactoferrin Favors control

The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study

Algahtani et al., Medicina, doi:10.3390/medicina57080842
Aug 2021  
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RCT 54 hospitalized patients in Egypt, showing no significant differences in recovery with lactoferrin treatment. 200mg lactoferrin orally once daily (group 1) or 200mg lactoferrin orally twice daily (group 2).
risk of unresolved fever, 25.0% lower, RR 0.75, p = 1.00, treatment 3 of 36 (8.3%), control 2 of 18 (11.1%), NNT 36, day 7.
risk of unresolved fatigue, 33.3% lower, RR 0.67, p = 0.67, treatment 4 of 36 (11.1%), control 3 of 18 (16.7%), NNT 18, day 7.
risk of unresolved cough, no change, RR 1.00, p = 1.00, treatment 8 of 36 (22.2%), control 4 of 18 (22.2%), day 7.
risk of unresolved headache, no change, RR 1.00, p = 1.00, treatment 4 of 36 (11.1%), control 2 of 18 (11.1%), day 7.
risk of unresolved loss of smell/taste, 25.0% lower, RR 0.75, p = 0.72, treatment 6 of 36 (16.7%), control 4 of 18 (22.2%), NNT 18, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Algahtani et al., 19 Aug 2021, Randomized Controlled Trial, Egypt, peer-reviewed, 6 authors, study period 8 July, 2020 - 18 September, 2020.
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This PaperLactoferrinAll
The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study
Fahad Dhafer Algahtani, Mohamed Tharwat Elabbasy, Mai A Samak, Adeniyi A Adeboye, Rafeek A Yusuf, Mohamed E Ghoniem
Medicina, doi:10.3390/medicina57080842
Background and Objectives: Preventive, adjunctive and curative properties of lactoferrin have been evaluated since the first wave of severe acute respiratory syndrome coronavirus (SARS-CoV), a viral respiratory disease, emerged 18 years ago. Despite the discovery of new vaccine candidates, there is currently no widely approved treatment for SARS-CoV-2 (COVID-19). Strict adherence to infection prevention and control procedures, as well as vaccines, can, however, prevent the spread of SARS-CoV-2. This study aimed to evaluate the efficacy of lactoferrin treatment in improving clinical symptoms and laboratory indices among individuals with mild to moderate coronavirus disease-19 (COVID-19). Materials and Method: A randomized, prospective, interventional pilot study conducted between 8 July and 18 September 2020 used a hospital-based sample of 54 laboratoryconfirmed participants with mild to moderate symptoms of COVID-19. Randomization into a control and two treatment groups ensured all groups received the approved Egyptian COVID-19 management protocol; only treatment group participants received lactoferrin at different doses for seven days. Clinical symptoms and laboratory indices were assessed on Days 0, 2 and 7 after starting treatments. Mean values with standard deviation and one-way analysis of variance with least significant difference of demographic and laboratory data between control and treatment groups were calculated. Results: Our study showed no statistically significant difference among studied groups regarding recovery of symptoms or laboratory improvement. Conclusions: Further research into therapeutic properties particularly related to dosage, duration and follow-up after treatment with lactoferrin in individuals with COVID-19 is required.
Conflicts of Interest: The authors declare that they have no conflict of interest. Abbreviations SARS-CoV-2: severe acute respiratory syndrome coronavirus-2; COVID-19: Coronavirus disease; Lf: Lactoferrin; Fe: Iron; WHO: World Health Organization; RT-PCR: reverse transcriptase polymerase chain reaction; LDH: Lactate dehydrogenase; ACE2: Angiotensin-converting enzyme 2; HSPGs: Heparan sulfate proteoglycans; IL: Interleukin; TNF alpha: Tumor Necrosis Factor alpha; CRP: C-reactive protein.
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Late treatment
is less effective
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