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All Studies   Meta Analysis    Recent:   

Can Zn Be a Critical Element in COVID-19 Treatment?

Rahman et al., Biological Trace Element Research, doi:10.1007/s12011-020-02194-9
May 2020  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Review of the potential benefits of zinc treatment for COVID-19. Zinc plays important roles in enhancing both innate and adaptive immunity against viral infections. The authors propose that zinc could inhibit SARS-CoV-2 replication by directly inhibiting the activity of the viral RNA-dependent RNA polymerase. Furthermore, chloroquine acts as an ionophore for zinc, allowing it to enter cells and exert antiviral effects. Authors also highlight how zinc treatment could work synergistically with other antiviral drugs being investigated for COVID-19 treatment. While acknowledging potential toxicity issues with excessive zinc intake, the authors argue that appropriate zinc treatment may be beneficial as part of COVID-19 treatment protocols.
Reviews covering zinc for COVID-19 include Arora, Briassoulis, Derwand, DiGuilio, Foshati, Jin, Joachimiak, Schloss, Sethuram, Wessels.
Review covers zinc and HCQ.
Rahman et al., 26 May 2020, peer-reviewed, 2 authors. Contact: m.tariqur.rahman@gmail.com, tarique@um.edu.my, syedzahir@iium.edu.my, szidid@gmail.com.
This PaperZincAll
Can Zn Be a Critical Element in COVID-19 Treatment?
Mohammad Tariqur Rahman, Syed Zahir Idid
Biological Trace Element Research, doi:10.1007/s12011-020-02194-9
The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective antiviral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. Furthermore, Zn has the ability to enhance innate and adaptive immunity in the course of a viral infection. Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the infected cell can stop SARS-CoV-2 replication. Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19.
Compliance with Ethical Standards Conflict of Interest The authors declare that they have no competing interests. Ethics Approval Not applicable. Consent to Participate (Include Appropriate Statements) Not applicable. Code Availability Not applicable. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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