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Does melatonin reduce mortality in COVID-19?

Pilia et al., Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103817 (meta analysis)
Pilia et al., Does melatonin reduce mortality in COVID-19?, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103817 (meta analysis)
May 2022   Source   PDF  
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Meta analysis of 3 melatonin RCTs showing significantly lower mortality with treatment. Authors note the small sample size in RCTs reporting mortality results to date.
Currently there are 18 melatonin studies and meta analysis shows:
OutcomeImprovement
Mortality48% lower [27‑63%]
Ventilation29% lower [14‑40%]
ICU admission6% lower [-4‑15%]
Hospitalization19% lower [-9‑40%]
Cases38% fewer [-6‑64%]
Pilia et al., 18 May 2022, Italy, peer-reviewed, 3 authors.
Contact: dotterospilia@gmail.com.
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Does melatonin reduce mortality in COVID-19?
MD Eros Pilia, MD Ettore Alborino, Remo Daniel Covello
Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103817
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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References
Farnoosh, Akbariqomi, Badri, Bagheri, Izadi et al., Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial, Arch Med Res, doi:10.1016/j.arcmed.2021.06.006
Hasan, Atrakji, Mehuaiden, The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients, Int J Infect Dis, doi:10.1016/j.ijid.2021.10.012
Mousavi, Heydari, Mehravaran, Saeedi, Alizadeh-Navaei et al., Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial, J Med Virol, doi:10.1002/jmv.27312
Shneider, Kudriavtsev, Vakhrusheva, Can melatonin reduce the severity of COVID-19 pandemic?, Int Rev Immunol, doi:10.1080/08830185.2020.1756284
Sánchez-Rico, De La Muela, Herrera-Morueco, Geoffroy, Limosin et al., Université de Paris/INSERM COVID-19 Research Collaboration/AP-HP COVID CDR Initiative/Entrepôt de Données de Santé AP-HP Consortium. Melatonin does not reduce mortality in adult hospitalized patients with COVID-19: a multicenter retrospective observational study, J Travel Med, doi:10.1093/jtm/taab195
Zhou, Hou, Shen, Huang, Martin et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discov, doi:10.1038/s41421-020-0153-3
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