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Home   COVID-19 treatment studies for Melatonin  COVID-19 treatment studies for Melatonin  C19 studies: Melatonin  Melatonin   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ ICU admission 81% Improvement Relative Risk Recovery time 49% Discharge 44% Time to discharge 43% c19early.org/j Farnoosh et al. Melatonin for COVID-19 RCT LATE TREATMENT Favors melatonin Favors control
Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial
Farnoosh et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.06.006
23 Jun 2021    Source   PDF   Share   Tweet
RCT 44 hospitalized patients in Iran, 24 treated with melatonin, showing faster recovery with treatment. There was no mortality.
risk of ICU admission, 81.5% lower, RR 0.19, p = 0.20, treatment 0 of 24 (0.0%), control 2 of 20 (10.0%), NNT 10.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
recovery time, 49.0% lower, relative time 0.51, p = 0.004, treatment 24, control 20.
risk of no hospital discharge, 44.4% lower, RR 0.56, p = 0.65, treatment 2 of 24 (8.3%), control 3 of 20 (15.0%), NNT 15.
time to discharge, 42.9% lower, relative time 0.57, p = 0.02, treatment 24, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Farnoosh et al., 23 Jun 2021, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 12 authors, average treatment delay 7.0 days.
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Late treatment
is less effective
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