The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
Zainab Thanon Hasan, Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji, Dr. Ahmed Kayes Mehuaiden
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012
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Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Ethical approval The patients provided informed consent to provide specimen and clinical data, and the study received approval by the ethical committee of Baghdad University /college of medicine.
References
Ali Ameri, Frouz, Manoochehr, Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: A structured summary of a study protocol for a randomized registration: 10
Konrad, Ron, Niranjan, Flavia, Raymond et al., Recognizing Sepsis as a Global Health Priority -A WHO Resolution, N Engl J Med
Phua, Ngerng, See, Characteristics and outcomes of culture-negative versus culture-positive severe sepsis, Crit Care
Singer, Deutschman, Seymour, The Third International Consensus definitions for sepsis and septic shock (Sepsis-3), JAMA
Slominski, Hardeland, Zmijewski, Slominski, Reiter et al., Melatonin: A cutaneous perspective on its production, metabolism, and functions, J. Invest. Dermatol
Soy, Keser, Atagündüz, Tabak, Atagündüz et al., Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment, Clin. Rheumatol,
doi:10.1007/s10067-020-05190-5
Steven, Thompson, None, Sampling
Varga, Flammer, Steiger, Endothelial cell infection and endotheliitis in COVID-19, Lancet
Qin, Zhou, Hu, Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect
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'prevention, antithrombotic therapy, and follow-up',
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'DOI': '10.1172/JCI137244',
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'disease 2019',
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'author': 'Chen',
'year': '2020',
'journal-title': 'J Clin Invest'},
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'first-page': '1421',
'DOI': '10.1111/jth.14830',
'article-title': 'Prevalence of venous thromboembolism in patients with severe novel '
'coronavirus pneumonia',
'volume': '18',
'author': 'Cui',
'year': '2020',
'journal-title': 'J Thromb Haemost'},
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'first-page': '83',
'article-title': 'Clinical trial to test the efficacy of melatonin in COVID-19',
'volume': '20',
'author': 'Dario',
'year': '2020',
'journal-title': 'J Pineal Res'},
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'series-title': 'Logistic Regression: Binary & Multinomial',
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'year': '2013'},
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'Melatonin as an Adjunctive Therapy in Hospitalized Patients with '
'COVID-19: A Randomized, Double-blind Clinical Trial. (2020) Clinical '
'Trials.gov Identifier: NCT0440952'},
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'DOI': '10.2174/1568026616666160824120338',
'article-title': 'Melatonin and respiratory diseases: a review',
'volume': '17',
'author': 'Habtemariam',
'year': '2017',
'journal-title': 'Curr Top Med Chem'},
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'first-page': '247',
'article-title': 'Responses of endothelial cells towards ischemic conditioning following '
'acute myocardial infarction',
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'author': 'Hernández-Reséndiz',
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'doi-asserted-by': 'crossref',
'first-page': '497',
'DOI': '10.1016/S0140-6736(20)30183-5',
'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in '
'Wuhan',
'volume': '95',
'author': 'Huang',
'year': '2020',
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'doi-asserted-by': 'crossref',
'DOI': '10.1148/radiol.2020201561',
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'relationship to D-dimer levels',
'volume': '296',
'author': 'Leonard-Lorant',
'year': '2020',
'journal-title': 'Radiology'},
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'doi-asserted-by': 'crossref',
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'article-title': 'Melatonin effect on endothelial cells reduces vascular permeability '
'increase induced by leukotriene B4',
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'year': '2006',
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'volume': '10',
'author': 'Ma',
'year': '2019',
'journal-title': 'Front Immunol'},
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'year': '2013',
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'year': '2020',
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'year': '2017',
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'double-blind, randomized placebo-controlled trial to explore the '
'efficacy and safety of intravenous melatonin in patients with COVID-19 '
'admitted to the intensive care unit (MelCOVID study): a structured '
'summary of a study protocol for a randomized controlled trial. EU '
'Clinical Trials Register. Date of trial registration: 10 July 2020. URL: '
'https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001808-42/ES.',
'DOI': '10.1186/s13063-020-04632-4'},
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'doi-asserted-by': 'crossref',
'first-page': '801',
'DOI': '10.1001/jama.2016.0287',
'article-title': 'The Third International Consensus definitions for sepsis and septic '
'shock (Sepsis-3)',
'volume': '315',
'author': 'Singer',
'year': '2016',
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'functions',
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'author': 'Slominski',
'year': '2018',
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'volume': '39',
'author': 'Soy',
'year': '2020',
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'article-title': 'Oral melatonin reduces blood coagulation activity: a placebo-controlled '
'study in healthy young men',
'volume': '44',
'author': 'Wirtz',
'year': '2008',
'journal-title': 'J. Pineal Res.'},
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