Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All melatonin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchMelatoninMelatonin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 93% Improvement Relative Risk Melatonin  Hasan et al.  LATE TREATMENT  RCT Is late treatment with melatonin beneficial for COVID-19? RCT 158 patients in Iraq (December 2020 - June 2021) Lower mortality with melatonin (p=0.0004) c19early.org Hasan et al., Int. J. Infectious Disea.., Oct 2021 Favors melatonin Favors control

The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

Hasan et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012
Oct 2021  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
RCT 158 severe condition patients in Iraq, 82 treated with melatonin, showing lower mortality, thrombosis, and sepsis with treatment.
risk of death, 92.9% lower, RR 0.07, p < 0.001, treatment 1 of 82 (1.2%), control 13 of 76 (17.1%), NNT 6.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hasan et al., 12 Oct 2021, Randomized Controlled Trial, Iraq, peer-reviewed, 3 authors, study period 1 December, 2020 - 1 June, 2021.
This PaperMelatoninAll
The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
Zainab Thanon Hasan, Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji, Dr. Ahmed Kayes Mehuaiden
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ethical approval The patients provided informed consent to provide specimen and clinical data, and the study received approval by the ethical committee of Baghdad University /college of medicine.
References
Ali Ameri, Frouz, Manoochehr, Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: A structured summary of a study protocol for a randomized registration: 10
Konrad, Ron, Niranjan, Flavia, Raymond et al., Recognizing Sepsis as a Global Health Priority -A WHO Resolution, N Engl J Med
Phua, Ngerng, See, Characteristics and outcomes of culture-negative versus culture-positive severe sepsis, Crit Care
Singer, Deutschman, Seymour, The Third International Consensus definitions for sepsis and septic shock (Sepsis-3), JAMA
Slominski, Hardeland, Zmijewski, Slominski, Reiter et al., Melatonin: A cutaneous perspective on its production, metabolism, and functions, J. Invest. Dermatol
Soy, Keser, Atagündüz, Tabak, Atagündüz et al., Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment, Clin. Rheumatol, doi:10.1007/s10067-020-05190-5
Steven, Thompson, None, Sampling
Varga, Flammer, Steiger, Endothelial cell infection and endotheliitis in COVID-19, Lancet
 Qin, Zhou, Hu, Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect
{ 'DOI': '10.1016/j.ijid.2021.10.012', 'ISSN': ['1201-9712'], 'URL': 'http://dx.doi.org/10.1016/j.ijid.2021.10.012', 'alternative-id': ['S1201971221007980'], 'assertion': [ {'label': 'This article is maintained by', 'name': 'publisher', 'value': 'Elsevier'}, { 'label': 'Article Title', 'name': 'articletitle', 'value': 'The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 ' 'Patients'}, { 'label': 'Journal Title', 'name': 'journaltitle', 'value': 'International Journal of Infectious Diseases'}, { 'label': 'CrossRef DOI link to publisher maintained version', 'name': 'articlelink', 'value': 'https://doi.org/10.1016/j.ijid.2021.10.012'}, {'label': 'Content Type', 'name': 'content_type', 'value': 'article'}, { 'label': 'Copyright', 'name': 'copyright', 'value': '© 2021 The Authors. Published by Elsevier Ltd on behalf of International ' 'Society for Infectious Diseases.'}], 'author': [ {'affiliation': [], 'family': 'Hasan', 'given': 'Zainab Thanon', 'sequence': 'first'}, { 'ORCID': 'http://orcid.org/0000-0001-5047-5854', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Atrakji', 'given': 'Dr. Mohammed Qasim Yahya Mal Allah Al', 'sequence': 'additional'}, { 'affiliation': [], 'family': 'Mehuaiden', 'given': 'Dr. Ahmed Kayes', 'sequence': 'additional'}], 'container-title': 'International Journal of Infectious Diseases', 'container-title-short': 'International Journal of Infectious Diseases', 'content-domain': { 'crossmark-restriction': True, 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.com', 'ijidonline.com', 'elsevier.com', 'sciencedirect.com']}, 'created': { 'date-parts': [[2021, 10, 13]], 'date-time': '2021-10-13T13:22:29Z', 'timestamp': 1634131349000}, 'deposited': { 'date-parts': [[2022, 5, 31]], 'date-time': '2022-05-31T21:32:21Z', 'timestamp': 1654032741000}, 'indexed': {'date-parts': [[2024, 4, 3]], 'date-time': '2024-04-03T17:14:22Z', 'timestamp': 1712164462302}, 'is-referenced-by-count': 47, 'issued': {'date-parts': [[2022, 1]]}, 'language': 'en', 'license': [ { 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2022, 1, 1]], 'date-time': '2022-01-01T00:00:00Z', 'timestamp': 1640995200000}}, { 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 10, 7]], 'date-time': '2021-10-07T00:00:00Z', 'timestamp': 1633564800000}}], 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1201971221007980?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1201971221007980?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'member': '78', 'original-title': [], 'page': '79-84', 'prefix': '10.1016', 'published': {'date-parts': [[2022, 1]]}, 'published-print': {'date-parts': [[2022, 1]]}, 'publisher': 'Elsevier BV', 'reference': [ { 'article-title': 'Evaluation of the effect of melatonin in patients with COVID-19-induced ' 'pneumonia admitted to the Intensive Care Unit: A structured summary of ' 'a study protocol for a randomized controlled trial', 'author': 'Ameri', 'journal-title': 'Iranian registry of clinical trial', 'key': '10.1016/j.ijid.2021.10.012_bib0001', 'year': '2021'}, { 'article-title': 'Targeting potential drivers of COVID-19: Neutrophil extracellular traps', 'author': 'Barnes', 'first-page': '217', 'issue': '6', 'journal-title': 'J Exp Med', 'key': '10.1016/j.ijid.2021.10.012_bib0002', 'year': '2020'}, { 'DOI': '10.21037/jtd.2019.12.85', 'article-title': 'Melatonin for the treatment of sepsis: The scientific rationale', 'author': 'Biancatelli', 'doi-asserted-by': 'crossref', 'first-page': '54', 'issue': 'Suppl 1', 'journal-title': 'J Thorac Dis', 'key': '10.1016/j.ijid.2021.10.012_bib0003', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1016/j.jacc.2020.04.031', 'article-title': 'COVID-19 and thrombotic or thromboembolic disease: implications for ' 'prevention, antithrombotic therapy, and follow-up', 'author': 'Bikdeli', 'doi-asserted-by': 'crossref', 'first-page': '2950', 'journal-title': 'J Am Coll Cardiol', 'key': '10.1016/j.ijid.2021.10.012_bib0004', 'volume': '75', 'year': '2020'}, { 'DOI': '10.1172/JCI137244', 'article-title': 'Clinical and immunological features of severe and moderate coronavirus ' 'disease 2019', 'author': 'Chen', 'doi-asserted-by': 'crossref', 'first-page': '2620', 'journal-title': 'J Clin Invest', 'key': '10.1016/j.ijid.2021.10.012_bib0005', 'volume': '130', 'year': '2020'}, { 'DOI': '10.1111/jth.14830', 'article-title': 'Prevalence of venous thromboembolism in patients with severe novel ' 'coronavirus pneumonia', 'author': 'Cui', 'doi-asserted-by': 'crossref', 'first-page': '1421', 'journal-title': 'J Thromb Haemost', 'key': '10.1016/j.ijid.2021.10.012_bib0006', 'volume': '18', 'year': '2020'}, { 'article-title': 'Clinical trial to test the efficacy of melatonin in COVID-19', 'author': 'Dario', 'first-page': '83', 'journal-title': 'J Pineal Res', 'key': '10.1016/j.ijid.2021.10.012_bib0007', 'volume': '20', 'year': '2020'}, { 'author': 'Garson', 'first-page': '1', 'key': '10.1016/j.ijid.2021.10.012_bib0008', 'series-title': 'Logistic Regression: Binary & Multinomial', 'year': '2013'}, { 'key': '10.1016/j.ijid.2021.10.012_bib0009', 'unstructured': 'Gholamreza, Mostafa, Taleb, et\xa0al. Efficacy of a Low Dose of ' 'Melatonin as an Adjunctive Therapy in Hospitalized Patients with ' 'COVID-19: A Randomized, Double-blind Clinical Trial. (2020) Clinical ' 'Trials.gov Identifier: NCT0440952'}, { 'DOI': '10.2174/1568026616666160824120338', 'article-title': 'Melatonin and respiratory diseases: a review', 'author': 'Habtemariam', 'doi-asserted-by': 'crossref', 'first-page': '467', 'journal-title': 'Curr Top Med Chem', 'key': '10.1016/j.ijid.2021.10.012_bib0010', 'volume': '17', 'year': '2017'}, { 'article-title': 'Responses of endothelial cells towards ischemic conditioning following ' 'acute myocardial infarction', 'author': 'Hernández-Reséndiz', 'first-page': '247', 'issue': '5', 'journal-title': 'Cond Med', 'key': '10.1016/j.ijid.2021.10.012_bib0011', 'volume': '1', 'year': '2018'}, { 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan', 'author': 'Huang', 'doi-asserted-by': 'crossref', 'first-page': '497', 'journal-title': 'China. Lancet', 'key': '10.1016/j.ijid.2021.10.012_bib0012', 'volume': '95', 'year': '2020'}, { 'DOI': '10.1148/radiol.2020201561', 'article-title': 'Acute pulmonary embolism in COVID-19 patients on CT angiography and ' 'relationship to D-dimer levels', 'author': 'Leonard-Lorant', 'doi-asserted-by': 'crossref', 'issue': '3', 'journal-title': 'Radiology', 'key': '10.1016/j.ijid.2021.10.012_bib0013', 'volume': '296', 'year': '2020'}, { 'DOI': '10.1016/j.ejphar.2006.01.050', 'article-title': 'Melatonin effect on endothelial cells reduces vascular permeability ' 'increase induced by leukotriene B4', 'author': 'Lotufo', 'doi-asserted-by': 'crossref', 'first-page': '258', 'journal-title': 'Eur J Pharmacol', 'key': '10.1016/j.ijid.2021.10.012_bib0014', 'year': '2006'}, { 'DOI': '10.3389/fimmu.2019.01037', 'article-title': 'Role of neutrophil extracellular traps and vesicles in regulating ' 'vascular endothelial permeability', 'author': 'Ma', 'doi-asserted-by': 'crossref', 'first-page': '1037', 'journal-title': 'Front Immunol', 'key': '10.1016/j.ijid.2021.10.012_bib0015', 'volume': '10', 'year': '2019'}, { 'DOI': '10.1186/cc12896', 'article-title': 'Characteristics and outcomes of culture-negative versus ' 'culture-positive severe sepsis', 'author': 'Phua', 'doi-asserted-by': 'crossref', 'first-page': '202', 'journal-title': 'Crit Care', 'key': '10.1016/j.ijid.2021.10.012_bib0016', 'volume': '17', 'year': '2013'}, { 'article-title': 'Dysregulation of immune response in patients with COVID-19 in Wuhan', 'author': 'Qin', 'first-page': '248', 'journal-title': 'China. Clin Infect.', 'key': '10.1016/j.ijid.2021.10.012_bib0017', 'volume': '10', 'year': '2020'}, { 'DOI': '10.1056/NEJMp1707170', 'article-title': 'Recognizing Sepsis as a Global Health Priority - A WHO Resolution', 'author': 'Reinhart', 'doi-asserted-by': 'crossref', 'first-page': '414', 'journal-title': 'N Engl J Med', 'key': '10.1016/j.ijid.2021.10.012_bib0018', 'volume': '377', 'year': '2017'}, { 'DOI': '10.1186/s13063-020-04632-4', 'doi-asserted-by': 'crossref', 'key': '10.1016/j.ijid.2021.10.012_bib0019', 'unstructured': 'Rodríguez-Rubio M, Figueira JC, et\xa0al. A phase II, single-center, ' 'double-blind, randomized placebo-controlled trial to explore the ' 'efficacy and safety of intravenous melatonin in patients with COVID-19 ' 'admitted to the intensive care unit (MelCOVID study): a structured ' 'summary of a study protocol for a randomized controlled trial. EU ' 'Clinical Trials Register. Date of trial registration: 10 July 2020. URL: ' 'https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001808-42/ES.'}, { 'DOI': '10.1001/jama.2016.0287', 'article-title': 'The Third International Consensus definitions for sepsis and septic ' 'shock (Sepsis-3)', 'author': 'Singer', 'doi-asserted-by': 'crossref', 'first-page': '801', 'journal-title': 'JAMA', 'key': '10.1016/j.ijid.2021.10.012_bib0020', 'volume': '315', 'year': '2016'}, { 'DOI': '10.1016/j.jid.2017.10.025', 'article-title': 'Melatonin: A cutaneous perspective on its production, metabolism, and ' 'functions', 'author': 'Slominski', 'doi-asserted-by': 'crossref', 'first-page': '490', 'journal-title': 'J Invest Dermatol', 'key': '10.1016/j.ijid.2021.10.012_bib0021', 'volume': '138', 'year': '2018'}, { 'DOI': '10.1007/s10067-020-05190-5', 'article-title': 'Cytokine storm in COVID-19: pathogenesis and overview of ' 'anti-inflammatory agents used in treatment', 'author': 'Soy', 'doi-asserted-by': 'crossref', 'first-page': '2085', 'journal-title': 'Clin Rheumatol', 'key': '10.1016/j.ijid.2021.10.012_bib0022', 'volume': '39', 'year': '2020'}, { 'author': 'Thompson', 'first-page': '59', 'journal-title': 'Sampling', 'key': '10.1016/j.ijid.2021.10.012_bib0023', 'volume': '3', 'year': '2012'}, { 'DOI': '10.1016/S0140-6736(20)30937-5', 'article-title': 'Endothelial cell infection and endotheliitis in COVID-19', 'author': 'Varga', 'doi-asserted-by': 'crossref', 'first-page': '1417', 'journal-title': 'Lancet', 'key': '10.1016/j.ijid.2021.10.012_bib0024', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1111/j.1600-079X.2007.00499.x', 'article-title': 'Oral melatonin reduces blood coagulation activity: a placebo-controlled ' 'study in healthy young men', 'author': 'Wirtz', 'doi-asserted-by': 'crossref', 'first-page': '127', 'issue': '2', 'journal-title': 'J. Pineal Res.', 'key': '10.1016/j.ijid.2021.10.012_bib0025', 'volume': '44', 'year': '2008'}, { 'key': '10.1016/j.ijid.2021.10.012_bib0026', 'unstructured': 'Worldometer. COVID-19 Coronavirus Pandemic. Available at: ' 'https://www.worldometers.info/coronavirus /. Accessed 1 June 2021.'}, { 'article-title': 'COVID-19: Melatonin as a potential adjuvant treatment', 'author': 'Zhang', 'journal-title': 'Life Sci', 'key': '10.1016/j.ijid.2021.10.012_bib0028', 'year': '2020'}, { 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'author': 'Zhou', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'issue': '10229', 'journal-title': 'Lancet', 'key': '10.1016/j.ijid.2021.10.012_bib0029', 'volume': '395', 'year': '2020'}], 'reference-count': 28, 'references-count': 28, 'relation': {}, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1201971221007980'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['Infectious Diseases', 'Microbiology (medical)', 'General Medicine'], 'subtitle': [], 'title': 'The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'volume': '114'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit