Hasan: The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

Hasan et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012

Hasan et al., The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012

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RCT 158 severe condition patients in Iraq, 82 treated with melatonin, showing lower mortality, thrombosis, and sepsis with treatment.

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risk of death, 92.9% lower, RR 0.07, p < 0.001, treatment 1 of 82 (1.2%), control 13 of 76 (17.1%), NNT 6.3.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Hasan et al., 12 Oct 2021, Randomized Controlled Trial, Iraq, peer-reviewed, 3 authors.

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The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

Zainab Thanon Hasan, Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji, Dr. Ahmed Kayes Mehuaiden

International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.10.012

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ethical approval The patients provided informed consent to provide specimen and clinical data, and the study received approval by the ethical committee of Baghdad University /college of medicine.

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Slominski, Hardeland, Zmijewski, Slominski, Reiter et al., Melatonin: A cutaneous perspective on its production, metabolism, and functions, J. Invest. Dermatol

Soy, Keser, Atagündüz, Tabak, Atagündüz et al., Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment, Clin. Rheumatol, doi:10.1007/s10067-020-05190-5

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 Qin, Zhou, Hu, Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect

Late treatment
is less effective

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