Efficacy of melatonin in the treatment of patients with COVID‐19: A systematic review and meta‐analysis of randomized controlled trials
Shao‐huan Lan, Hong‐zin Lee, Chien‐ming Chao, Shen‐peng Chang, Li‐chin Lu, Chih‐cheng Lai
Journal of Medical Virology, doi:10.1002/jmv.27595
This study investigated the effect of melatonin on clinical outcomes in patients with COVID-19. We searched PubMed, the Web of Science, the Cochrane Library, Ovid MEDLINE, and Clinicaltrials.gov for randomized controlled trials (RCTs) published before September 11, 2021. Only RCTs that compared the clinical efficacy of melatonin with a placebo in the treatment of patients with COVID-19 was included. The primary outcome measure was the clinical recovery rate. We included 3 RCTs in this meta-analysis. Melatonin 3 mg thrice daily was administered in one RCT, and 3 or 6 mg daily before bedtime in other two trials. Treatment duration was 14 days in two RCTs and 7 days in one trial. The clinical recovery rates were 94.2% (81/86) and 82.4% (70/85) in the melatonin and control groups, respectively. Overall, patients receiving melatonin had a higher clinical recovery rate than did the controls (odds ratio [OR], 3.67; 95% CI, 1.21-11.12; I 2 = 0%, P = .02). The risk of intensive care unit admission was numerically lower in the melatonin group than in the control group (8.3% [6/72] vs 17.6% [12/68], OR, 0.45; 95% CI, 0.16-1.25; I 2 = 0%, P = .13), and the risk of mortality was numerically lower in the melatonin group than in the control group (1.4% [1/72] vs 4.4% [3/68], OR, 0.32; 95% CI, 0.03-3.18; I 2 = 0%, P = .33). In conclusion, melatonin may help improve the clinical outcomes of patients with COVID-19.
Accepted
Article in the treatment of COVID-19. Finally, because the definition of the rate of clinical recovery was not comprehensively described in the original studies, we were unable to make imprecise statement regarding this outcome. In conclusion, this meta-analysis revealed that melatonin may help improve the clinical outcomes of patients with COVID-19 and suggested its potential role. However, further large-scale research is required to confirm our findings.
Conflict of
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