Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis

Taha et al., Advances in Medical Sciences, doi:10.1016/j.advms.2023.09.007

Sep 2023

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Systematic review and meta analysis of 11 COVID-19 studies showing significantly higher clinical improvement and shorter hospitalization and mechanical ventilation time with melatonin treatment.

5 meta analyses show significant improvements with melatonin for mortality Pilia, Tóth, mechanical ventilation Taha, hospitalization Taha, improvement Taha, and recovery Lan, Wang.

Currently there are 18 melatonin for COVID-19 studies, showing 48% lower mortality [27‑63%], 29% lower ventilation [14‑40%], 6% lower ICU admission [-4‑15%], 19% lower hospitalization [-9‑40%], and 38% fewer cases [-6‑64%].

1. Lan et al., Efficacy of Melatonin in the Treatment of Patients With COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Medical Virology, doi:10.1002/jmv.27595.wiley.com, doi.org.

2. Pilia et al., Does melatonin reduce mortality in COVID-19?, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103817.sciencedirect.com, doi.org.

3. Taha et al., Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis, Advances in Medical Sciences, doi:10.1016/j.advms.2023.09.007.sciencedirect.com, doi.org.

4. Tóth et al., Melatonin as adjuvant treatment in COVID-19 patients. A meta-analysis of randomized and propensity matched studies, Signa Vitae, doi:10.22514/sv.2023.076.signavitae.com, doi.org.

5. Wang et al., The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis, Medicine, doi:10.1097/MD.0000000000030874.lww.com, doi.org.

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Taha et al., 22 Sep 2023, peer-reviewed, 8 authors.

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