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Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis

Taha et al., Advances in Medical Sciences, doi:10.1016/j.advms.2023.09.007
Sep 2023  
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Systematic review and meta analysis of 11 COVID-19 studies showing significantly higher clinical improvement and shorter hospitalization and mechanical ventilation time with melatonin treatment.
5 meta analyses show significant improvements with melatonin for mortality Pilia, Tóth, mechanical ventilation Taha, hospitalization Taha, improvement Taha, and recovery Lan, Wang.
Currently there are 18 melatonin for COVID-19 studies, showing 48% lower mortality [27‑63%], 29% lower ventilation [14‑40%], 6% lower ICU admission [-4‑15%], 19% lower hospitalization [-9‑40%], and 38% fewer cases [-6‑64%].
Taha et al., 22 Sep 2023, peer-reviewed, 8 authors.
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