Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis

Taha et al., Advances in Medical Sciences, doi:10.1016/j.advms.2023.09.007, Sep 2023

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Melatonin for COVID-19

11th treatment shown to reduce risk in December 2020, now with p = 0.000000047 from 19 studies.

Lower risk for mortality, ventilation, and recovery.

No treatment is 100% effective. Protocols combine treatments.

5,700+ studies for 169 treatments. c19early.org

Systematic review and meta analysis of 11 COVID-19 studies showing significantly higher clinical improvement and shorter hospitalization and mechanical ventilation time with melatonin treatment.

7 meta analyses show significant improvements with melatonin for mortality1-4, mechanical ventilation5, hospitalization3,5, improvement5, and recovery6,7.

Currently there are 19 melatonin for COVID-19 studies, showing 48% lower mortality [28‑62%], 29% lower ventilation [14‑40%], 6% lower ICU admission [-4‑15%], 19% lower hospitalization [-9‑40%], and 38% fewer cases [-6‑64%].

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1. Pilia et al., Does melatonin reduce mortality in COVID-19?, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103817.sciencedirect.com, doi.org.

2. Tóth et al., Melatonin as adjuvant treatment in COVID-19 patients. A meta-analysis of randomized and propensity matched studies, Signa Vitae, doi:10.22514/sv.2023.076.signavitae.com, doi.org.

3. Amin et al., Role of Melatonin in Management of COVID-19: A Systematic Review, Microbes, Infection and Chemotherapy, doi:10.54034/mic.e1982.edu.pe, doi.org.

4. Qin et al., Benefits of melatonin on mortality in severe-to-critical COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials, Clinics, doi:10.1016/j.clinsp.2025.100638.sciencedirect.com, doi.org.

5. Taha et al., Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis, Advances in Medical Sciences, doi:10.1016/j.advms.2023.09.007.sciencedirect.com, doi.org.

6. Lan et al., Efficacy of Melatonin in the Treatment of Patients With COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Medical Virology, doi:10.1002/jmv.27595.wiley.com, doi.org.

7. Wang et al., The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis, Medicine, doi:10.1097/MD.0000000000030874.lww.com, doi.org.

Taha et al., 22 Sep 2023, peer-reviewed, 8 authors.

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.

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