Top
Main
 
All Outcomes
 
RCT vs. Obs.
 
Feedback
Home
c19early.org COVID-19 treatment researchAlkalinizationAlkalinization (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

Loading...
More

Supplementary Data — Alkalinization for COVID-19: real-time meta analysis of 14 studies

@CovidAnalysis, December 2024, Version 13V13
 
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Yilmaz (SB RCT) 86% 0.14 [0.01-2.65] hosp. 0/30 3/30 alkaline solution Improvement, RR [CI] Treatment Control Yilmaz (SB RCT) 62% 0.4 [0.00-2e+04] viral load 30 (n) 30 (n) alkaline solution Yilmaz (SB RCT) 43% 0.6 [0.00-2e+06] viral load 30 (n) 30 (n) alkaline solution Baxter (RCT) 65% 0.35 [0.01-8.27] hosp. 0/37 1/42 sodium bicarb. OT​1 SeaCare de Gabory (RCT) 75% 0.25 [0.12-0.54] progression 7/82 31/91 alkaline seawater SeaCare de Gabory (RCT) 68% 0.32 [0.15-0.71] progression 7/82 24/91 alkaline seawater SeaCare de Gabory (RCT) 35% 0.65 [0.27-1.57] progression 7/82 12/91 alkaline seawater SeaCare de Gabory (RCT) 24% 0.76 [0.60-0.96] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 17% 0.83 [0.76-0.91] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 26% 0.74 [0.57-0.97] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 29% 0.71 [0.57-0.87] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 26% 0.74 [0.61-0.92] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 14% 0.86 [0.68-1.09] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 11% 0.89 [0.70-1.13] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) -2% 1.02 [0.80-1.29] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 25% 0.75 [0.56-0.99] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 3% 0.97 [0.77-1.21] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 14% 0.86 [0.68-1.09] recov. time 82 (n) 91 (n) alkaline seawater SeaCare de Gabory (RCT) 37% 0.63 [0.19-2.09] viral+ 4/82 7/91 alkaline seawater Mody (RCT) 64% 0.36 [0.19-0.68] no improv. 8/30 22/30 sodium bicarb. Salva 45% 0.55 [0.35-0.85] death 35/327 34/174 alkaline ibuprofen CT​2 Salva 76% 0.24 [0.14-0.43] death 11/56 17/21 alkaline ibuprofen CT​2 Salva 14% 0.86 [0.83-0.90] hosp. time 327 (n) 174 (n) alkaline ibuprofen CT​2 Salva 18% 0.82 [0.74-0.91] hosp. time 56 (n) 21 (n) alkaline ibuprofen CT​2 Soares (ICU) 76% 0.24 [0.11-0.54] death 6/44 18/32 ICU patients sodium bicarb. Delić (RCT) 23% 0.77 [0.56-1.06] death 23/42 37/52 Intubated patients sodium bicarb. Delić (RCT) 20% 0.80 [0.54-1.18] death 20/42 31/52 Intubated patients sodium bicarb. Calonico 49% 0.51 [0.31-0.85] death 1,019 (n) 3,303 (n) alkaline ibuprofen CT​2 El-Badrawy 57% 0.43 [0.09-2.08] death 3/127 3/55 sodium bicarb. El-Badrawy 39% 0.61 [0.20-1.83] progression 7/127 5/55 sodium bicarb. El-Badrawy 19% 0.81 [0.68-0.96] no recov. 84/127 45/55 sodium bicarb. El-Badrawy 73% 0.27 [0.14-0.52] no recov. 127 (n) 55 (n) sodium bicarb. El-Badrawy 66% 0.34 [0.25-0.47] recov. time 127 (n) 55 (n) sodium bicarb. El-Badrawy (RCT) 23% 0.77 [0.50-1.18] death 32/272 42/274 sodium bicarb. El-Badrawy (RCT) 55% 0.45 [0.23-0.87] death 12/247 27/251 sodium bicarb. El-Badrawy (RCT) 79% 0.21 [0.02-1.76] death 1/125 5/130 sodium bicarb. El-Badrawy (RCT) 53% 0.47 [0.25-0.88] death 11/63 22/59 sodium bicarb. El-Badrawy (RCT) -23% 1.23 [0.86-1.75] death 20/25 15/23 sodium bicarb. El-Badrawy (RCT) 28% 0.72 [0.66-0.80] recov. time 272 (n) 274 (n) sodium bicarb. El-Badrawy (RCT) 33% 0.67 [0.52-0.85] no recov. 238 (n) 229 (n) sodium bicarb. Kalayan 79% 0.21 [0.07-0.65] death 3/37 24/62 alkaline ibuprofen CT​2 Wang (RCT) 39% 0.61 [0.46-0.82] hosp. time 23 (n) 32 (n) sodium bicarb. Pantazop.. (SB RCT) 67% 0.33 [0.01-7.85] death 0/28 1/28 alkaline seawater Pantazop.. (SB RCT) 67% 0.33 [0.01-7.85] ICU 0/28 1/28 alkaline seawater Pantazop.. (SB RCT) 80% 0.20 [0.01-3.99] oxygen 0/28 2/28 alkaline seawater Pantazop.. (SB RCT) 42% 0.58 [0.34-0.98] viral+ 11/28 19/28 alkaline seawater Karami (DB RCT) 45% 0.55 [0.24-1.22] symptoms 40 (n) 40 (n) sodium bicarb. Karami (DB RCT) 43% 0.57 [0.17-1.99] symptoms 36 (n) 40 (n) sodium bicarb. Karami (DB RCT) 42% 0.58 [0.22-1.51] symptoms 36 (n) 40 (n) sodium bicarb. Karami (DB RCT) 79% 0.21 [0.04-0.97] symptoms 36 (n) 40 (n) sodium bicarb. Karami (DB RCT) 18% 0.82 [0.22-2.96] symptoms 36 (n) 40 (n) sodium bicarb. Karami (DB RCT) 39% 0.61 [0.33-1.12] cases 11/40 18/40 sodium bicarb. Alkalinization COVID-19 outcomes c19early.org December 2024 1 OT: comparison with other treatment2 CT: study uses combined treatment Favors alkalinization Favors control
Figure S1. All outcomes.
Loading..
Figure S2. Comparison of results for RCTs versus observational studies. For COVID-19 treatments, there is no significant difference between the results of RCTs and observational studies. Observational studies do not systematically over or underestimate efficacy. For high-cost treatments, there is a non-significant trend towards RCTs showing greater efficacy.
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit