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c19early.org COVID-19 treatment researchBamlanivimab/etesevimabBamlaniv../e.. (more..)
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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -61% Improvement Relative Risk ICU admission -51% Hospitalization 49% Progression 39% Bamlanivimab/e..  Nagler et al.  EARLY TREATMENT Is early treatment with bamlanivimab/etesevimab beneficial for COVID-19? PSM retrospective 2,688 patients in the USA (Nov 2020 - May 2021) Lower hospitalization (p<0.0001) and progression (p<0.0001) c19early.org Nagler et al., American J. Health-Syst.., Oct 2022 Favors bamlanivimab/e.. Favors control

The impact of COVID-19 monoclonal antibodies on clinical outcomes: A retrospective cohort study

Nagler et al., American Journal of Health-System Pharmacy, doi:10.1093/ajhp/zxac295
Oct 2022  
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23rd treatment shown to reduce risk in June 2021
 
*, now known with p = 0.0005 from 17 studies, recognized in 3 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
PSM retrospective 1,344 patients in the USA, showing lower hospitalization with monoclonal antibody treatment. Authors combine patients treated with bamlanivimab, bamlanivimab/etesevimab, or casirivimab/imdevimab.
Efficacy is highly variant dependent. In Vitro research suggests a lack of efficacy for omicron Haars, Liu, Pochtovyi, Sheward, VanBlargan.
This study is excluded in meta analysis: results are only provided for use of one or more treatments within a class of treatments, results for each treatment are not provided.
Study covers casirivimab/imdevimab and bamlanivimab/etesevimab.
risk of death, 61.0% higher, RR 1.61, p = 0.40, treatment 1,344, control 1,344, propensity score matching.
risk of ICU admission, 51.0% higher, RR 1.51, p = 0.50, treatment 1,344, control 1,344, propensity score matching.
risk of hospitalization, 49.0% lower, RR 0.51, p < 0.001, treatment 1,344, control 1,344, propensity score matching.
risk of progression, 39.0% lower, RR 0.61, p < 0.001, treatment 1,344, control 1,344, ER visit, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nagler et al., 15 Oct 2022, retrospective, USA, peer-reviewed, mean age 59.5, 14 authors, study period 24 November, 2020 - 15 May, 2021. Contact: arielle.nagler@nyumc.org.
This PaperBamlaniv../e..All
Abstract: The impact of COVID-19 monoclonal antibodies on clinical outcomes: A retrospective cohort study Arielle R. Nagler, MD, The Ronald O. Perelman Department of Dermatology, NYU Grossman t us cr ip Leora I. Horwitz, MD, MHS, Department of Medicine and Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA Simon Jones, PhD, Department of Population Health, NYU Grossman School of Medicine, M an New York, NY, USA d Christopher M. Petrilli, MD, NYU Grossman School of Medicine, New York, NY, USA ce York, NY, USA pt e Eduardo Iturrate, MD, Department of Medicine, NYU Grossman School of Medicine, New Ac Jennifer L. Lighter, MD, Division of Pediatric Infectious Diseases, Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA Michael Phillips, MD, Division of Infectious Disease, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA © American Society of Health-System Pharmacists 2022. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. School of Medicine, New York, NY, USA Brian P. Bosworth, MD, Department of Medicine, NYU Grossman School of Medicine, New York, NY, and NYU Langone Health, New York, NY, USA Bruce Polsky, MD, Department of Medicine, NYU Long Island School of Medicine, New York, t us cr ip Frank M. Volpicelli, MD, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA an Isaac Dapkins, MD, Family Health Centers at NYU Langone, Brooklyn, NY, USA M Anand Viswanathan, MD, Department of Medicine, NYU Grossman School of Medicine, pt e d New York, NY, USA Fritz François, MD, Department of Medicine, NYU Grossman School of Medicine, New York, ce NY, and NYU Langone Health, New York, NY, USA Ac Gary Kalkut, MD, MPH, Division of Infectious Disease, Department of Medicine, NYU Grossman School of Medicine, New York, NY, and NYU Langone Health, New York, NY, USA Address correspondence to Dr. Nagler (Arielle.Nagler@nyumc.org). Twitter: @ArielleNaglerMD NY, USA Purpose: Despite progress in the treatment of coronavirus disease 2019 (COVID-19), including the development of monoclonal antibodies (mAbs), more clinical data to support the use of mAbs in outpatients with COVID-19 is needed. This study is designed to determine the impact of bamlanivimab, bamlanivimab/etesevimab, or t Methods: A retrospective cohort study was conducted at a single academic medical center us cr ip with 3 campuses in Manhattan, Brooklyn, and Long Island, NY. Patients 12 years of age or older who tested positive for COVID-19 or were treated with a COVID-19–specific therapy, including COVID-19 mAb therapies, at the study site between November 24, 2020, and May 15, 2021, were included. The primary outcomes included rates of emergency department M from the date of COVID-19 diagnosis. an (ED) visit, inpatient admission, intensive care unit (ICU) admission, or death within 30 days Results: A total of 1,344 mAb-treated patients were propensity matched to 1,344 patients d with COVID-19 patients who were not treated with mAb therapy. Within 30 days of pt e diagnosis, among the patients who received mAb therapy, 101 (7.5%) presented to the ED and 79 (5.9%) were admitted...
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