Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All casirivimab/imdevimab..
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchCasirivimab/imdevimabCasirivimab/i.. (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The impact of COVID-19 monoclonal antibodies on clinical outcomes: A retrospective cohort study

Nagler et al., American Journal of Health-System Pharmacy, doi:10.1093/ajhp/zxac295
Oct 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality -61% Improvement Relative Risk ICU admission -51% Hospitalization 49% Progression 39% Casirivimab/i..  Nagler et al.  EARLY TREATMENT Is early treatment with casirivimab/imdevimab beneficial for COVID-19? PSM retrospective 2,688 patients in the USA (Nov 2020 - May 2021) Lower hospitalization (p<0.0001) and progression (p<0.0001) c19early.org Nagler et al., American J. Health-Syst.., Oct 2022 Favorscasirivimab/im.. Favorscontrol 0 0.5 1 1.5 2+
17th treatment shown to reduce risk in March 2021
 
*, now with p = 0.000055 from 29 studies, recognized in 45 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
PSM retrospective 1,344 patients in the USA, showing lower hospitalization with monoclonal antibody treatment. Authors combine patients treated with bamlanivimab, bamlanivimab/etesevimab, or casirivimab/imdevimab.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants1-6.
This study is excluded in meta analysis: results are only provided for use of one or more treatments within a class of treatments, results for each treatment are not provided.
Study covers casirivimab/imdevimab and bamlanivimab/etesevimab.
risk of death, 61.0% higher, RR 1.61, p = 0.40, treatment 1,344, control 1,344, propensity score matching.
risk of ICU admission, 51.0% higher, RR 1.51, p = 0.50, treatment 1,344, control 1,344, propensity score matching.
risk of hospitalization, 49.0% lower, RR 0.51, p < 0.001, treatment 1,344, control 1,344, propensity score matching.
risk of progression, 39.0% lower, RR 0.61, p < 0.001, treatment 1,344, control 1,344, ER visit, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nagler et al., 15 Oct 2022, retrospective, USA, peer-reviewed, mean age 59.5, 14 authors, study period 24 November, 2020 - 15 May, 2021. Contact: arielle.nagler@nyumc.org.
This PaperCasirivimab/i..All
Abstract: The impact of COVID-19 monoclonal antibodies on clinical outcomes: A retrospective cohort study Arielle R. Nagler, MD, The Ronald O. Perelman Department of Dermatology, NYU Grossman t us cr ip Leora I. Horwitz, MD, MHS, Department of Medicine and Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA Simon Jones, PhD, Department of Population Health, NYU Grossman School of Medicine, M an New York, NY, USA d Christopher M. Petrilli, MD, NYU Grossman School of Medicine, New York, NY, USA ce York, NY, USA pt e Eduardo Iturrate, MD, Department of Medicine, NYU Grossman School of Medicine, New Ac Jennifer L. Lighter, MD, Division of Pediatric Infectious Diseases, Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA Michael Phillips, MD, Division of Infectious Disease, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA © American Society of Health-System Pharmacists 2022. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. School of Medicine, New York, NY, USA Brian P. Bosworth, MD, Department of Medicine, NYU Grossman School of Medicine, New York, NY, and NYU Langone Health, New York, NY, USA Bruce Polsky, MD, Department of Medicine, NYU Long Island School of Medicine, New York, t us cr ip Frank M. Volpicelli, MD, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA an Isaac Dapkins, MD, Family Health Centers at NYU Langone, Brooklyn, NY, USA M Anand Viswanathan, MD, Department of Medicine, NYU Grossman School of Medicine, pt e d New York, NY, USA Fritz François, MD, Department of Medicine, NYU Grossman School of Medicine, New York, ce NY, and NYU Langone Health, New York, NY, USA Ac Gary Kalkut, MD, MPH, Division of Infectious Disease, Department of Medicine, NYU Grossman School of Medicine, New York, NY, and NYU Langone Health, New York, NY, USA Address correspondence to Dr. Nagler (Arielle.Nagler@nyumc.org). Twitter: @ArielleNaglerMD NY, USA Purpose: Despite progress in the treatment of coronavirus disease 2019 (COVID-19), including the development of monoclonal antibodies (mAbs), more clinical data to support the use of mAbs in outpatients with COVID-19 is needed. This study is designed to determine the impact of bamlanivimab, bamlanivimab/etesevimab, or t Methods: A retrospective cohort study was conducted at a single academic medical center us cr ip with 3 campuses in Manhattan, Brooklyn, and Long Island, NY. Patients 12 years of age or older who tested positive for COVID-19 or were treated with a COVID-19–specific therapy, including COVID-19 mAb therapies, at the study site between November 24, 2020, and May 15, 2021, were included. The primary outcomes included rates of emergency department M from the date of COVID-19 diagnosis. an (ED) visit, inpatient admission, intensive care unit (ICU) admission, or death within 30 days Results: A total of 1,344 mAb-treated patients were propensity matched to 1,344 patients d with COVID-19 patients who were not treated with mAb therapy. Within 30 days of pt e diagnosis, among the patients who received mAb therapy, 101 (7.5%) presented to the ED and 79 (5.9%) were admitted...
{ 'indexed': { 'date-parts': [[2022, 10, 15]], 'date-time': '2022-10-15T17:42:43Z', 'timestamp': 1665855763377}, 'reference-count': 0, 'publisher': 'Oxford University Press (OUP)', 'license': [ { 'start': { 'date-parts': [[2022, 10, 15]], 'date-time': '2022-10-15T00:00:00Z', 'timestamp': 1665792000000}, 'content-version': 'am', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/pages/standard-publication-reuse-rights'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Disclaimer</jats:title>\n' ' <jats:p>In an effort to expedite the publication of articles, AJHP is ' 'posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have ' 'been peer-reviewed and copyedited, but are posted online before technical formatting and ' 'author proofing. These manuscripts are not the final version of record and will be replaced ' 'with the final article (formatted per AJHP style and proofed by the authors) at a later ' 'time.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Purpose</jats:title>\n' ' <jats:p>Despite progress in the treatment of coronavirus disease 2019 ' '(COVID-19), including the development of monoclonal antibodies (mAbs), more clinical data to ' 'support the use of mAbs in outpatients with COVID-19 is needed. This study is designed to ' 'determine the impact of bamlanivimab, bamlanivimab/etesevimab, or casirivimab/imdevimab on ' 'clinical outcomes within 30 days of COVID-19 diagnosis.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A retrospective cohort study was conducted at a single academic ' 'medical center with 3 campuses in Manhattan, Brooklyn, and Long Island, NY. Patients 12 years ' 'of age or older who tested positive for COVID-19 or were treated with a COVID-19–specific ' 'therapy, including COVID-19 mAb therapies, at the study site between November 24, 2020, and ' 'May 15, 2021, were included. The primary outcomes included rates of emergency department (ED) ' 'visit, inpatient admission, intensive care unit (ICU) admission, or death within 30 days from ' 'the date of COVID-19 diagnosis.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>A total of 1,344 mAb-treated patients were propensity matched to ' '1,344 patients with COVID-19 patients who were not treated with mAb therapy. Within 30 days ' 'of diagnosis, among the patients who received mAb therapy, 101 (7.5%) presented to the ED and ' '79 (5.9%) were admitted. Among the patients who did not receive mAb therapy, 165 (12.3%) ' 'presented to the ED and 156 (11.6%) were admitted (relative risk [RR], 0.61 [95% CI, ' '0.50-0.75] and 0.51 [95% CI, 0.40-0.64], respectively). Four mAb patients (0.3%) and 2.64 ' 'control patients (0.2%) were admitted to the ICU (RR, 01.51; 95% CI, 0.45-5.09). Six ' 'mAb-treated patients (0.4%) and 3.37 controls (0.3%) died and/or were admitted to hospice ' '(RR, 1.61; 95% CI, 0.54-4.83). mAb therapy in ambulatory patients with COVID-19 decreases the ' 'risk of ED presentation and hospital admission within 30 days of diagnosis.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/ajhp/zxac295', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 10, 15]], 'date-time': '2022-10-15T17:06:42Z', 'timestamp': 1665853602000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The impact of COVID-19 monoclonal antibodies on clinical outcomes: A retrospective cohort study', 'prefix': '10.1093', 'author': [ { 'given': 'Arielle R', 'family': 'Nagler', 'sequence': 'first', 'affiliation': [ { 'name': 'The Ronald O. Perelman Department of Dermatology, NYU Grossman ' 'School of Medicine, New York , NY, USA'}]}, { 'given': 'Leora I', 'family': 'Horwitz', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine and Department of Population Health, NYU ' 'Grossman School of Medicine, New York , NY, USA'}]}, { 'given': 'Simon', 'family': 'Jones', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Population Health, NYU Grossman School of ' 'Medicine, New York , NY, USA'}]}, { 'given': 'Christopher M', 'family': 'Petrilli', 'sequence': 'additional', 'affiliation': [{'name': 'NYU Grossman School of Medicine, New York , NY, USA'}]}, { 'given': 'Eduardo', 'family': 'Iturrate', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Grossman School of Medicine, New ' 'York , NY, USA'}]}, { 'given': 'Jennifer L', 'family': 'Lighter', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Pediatric Infectious Diseases, Department of ' 'Pediatrics, NYU Grossman School of Medicine, New York , NY, ' 'USA'}]}, { 'given': 'Michael', 'family': 'Phillips', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Infectious Disease, Department of Medicine, NYU ' 'Grossman School of Medicine, New York , NY, USA'}]}, { 'given': 'Brian P', 'family': 'Bosworth', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Grossman School of Medicine, New ' 'York , NY, andNYU Langone Health, New York, NY, USA'}]}, { 'given': 'Bruce', 'family': 'Polsky', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Long Island School of Medicine, New ' 'York , NY, USA'}]}, { 'given': 'Frank M', 'family': 'Volpicelli', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Grossman School of Medicine, New ' 'York , NY, USA'}]}, { 'given': 'Isaac', 'family': 'Dapkins', 'sequence': 'additional', 'affiliation': [{'name': 'Family Health Centers at NYU Langone, Brooklyn , NY, USA'}]}, { 'given': 'Anand', 'family': 'Viswanathan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Grossman School of Medicine, New ' 'York , NY, USA'}]}, { 'given': 'Fritz', 'family': 'François', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, NYU Grossman School of Medicine, New ' 'York , NY, and NYU Langone Health, New York, NY, USA'}]}, { 'given': 'Gary', 'family': 'Kalkut', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Infectious Disease, Department of Medicine, NYU ' 'Grossman School of Medicine, New York , NY, and NYU Langone ' 'Health, New York, NY, USA'}]}], 'member': '286', 'published-online': {'date-parts': [[2022, 10, 15]]}, 'container-title': 'American Journal of Health-System Pharmacy', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/ajhp/advance-article-pdf/doi/10.1093/ajhp/zxac295/46539445/zxac295.pdf', 'content-type': 'application/pdf', 'content-version': 'am', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/ajhp/advance-article-pdf/doi/10.1093/ajhp/zxac295/46539445/zxac295.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 10, 15]], 'date-time': '2022-10-15T17:06:43Z', 'timestamp': 1665853603000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://academic.oup.com/ajhp/advance-article/doi/10.1093/ajhp/zxac295/6761664'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 10, 15]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.1093/ajhp/zxac295', 'relation': {}, 'ISSN': ['1079-2082', '1535-2900'], 'subject': ['Health Policy', 'Pharmacology'], 'published': {'date-parts': [[2022, 10, 15]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit