Evaluation of the mutagenic effects of Molnupiravir and N4-hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
et al., Environmental and Molecular Mutagenesis, doi:10.1002/em.22510, Oct 2022
In vitro genotoxocity study of molnupiravir showing dose dependent increased genome-wide mutation frequencies with mouse lymphoma L5178Y and human lymphoblastoid TK6 cells.
Potential risks of molnupiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-15. Multiple analyses have identified variants potentially created by molnupiravir16-20.
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Miranda et al., 1 Oct 2022, peer-reviewed, 4 authors.
In vitro studies are an important part of preclinical research, however results may be very different in vivo.
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