Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Lactoferrin  COVID-19 treatment studies for Lactoferrin  C19 studies: Lactoferrin  Lactoferrin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality, day 28 -12% Improvement Relative Risk Mortality, day 14 -24% Ventilation -45% Death/ICU -6% Not reaching NEWS2 ≤2 o.. -34% c19early.org/lf Matino et al. NCT04847791 LAC Lactoferrin RCT LATE Is late treatment with lactoferrin beneficial for COVID-19? Double-blind RCT 218 patients in Italy Higher ventilation with lactoferrin (not stat. sig., p=0.39) Matino et al., Nutrients, doi:10.3390/nu15051285 Favors lactoferrin Favors control
Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial
Matino et al., Nutrients, doi:10.3390/nu15051285, LAC, NCT04847791 (history)
Matino et al., Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical.., Nutrients, doi:10.3390/nu15051285, LAC, NCT04847791
Mar 2023   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
RCT 218 hospitalized patients in Italy, showing no significant differences with lactoferrin treatment. Authors note that in several previous studies showing clinical improvement, lactoferrin was given at an earlier stage of disease. Authors also note that potential benefits with the late treatment in this study could be masked by other SOC medications - corticosteroids may have masked immunomodulatory effects of lactoferrin, and there may be heparin-dependent reduction in lactoferrin antiviral activity. 800mg oral bovine lactoferrin daily.
risk of death, 11.5% higher, RR 1.12, p = 0.85, treatment 18 of 113 (15.9%), control 15 of 105 (14.3%), day 28.
risk of death, 23.9% higher, RR 1.24, p = 0.69, treatment 16 of 113 (14.2%), control 12 of 105 (11.4%), day 14.
risk of mechanical ventilation, 44.5% higher, RR 1.45, p = 0.39, treatment 14 of 113 (12.4%), control 9 of 105 (8.6%).
risk of death/ICU, 6.2% higher, RR 1.06, p = 0.87, treatment 24 of 113 (21.2%), control 21 of 105 (20.0%).
not reaching NEWS2 ≤2 or discharge within 14 days, 33.6% higher, RR 1.34, p = 0.12, treatment 46 of 113 (40.7%), control 32 of 105 (30.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Matino et al., 4 Mar 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Italy, peer-reviewed, 53 authors, average treatment delay 6.0 days, trial NCT04847791 (history) (LAC).
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperLactoferrinAll
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit