Kurniyanto: Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral Academic Hospital in East Jakarta, Indonesia [Remdesivir]

Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral Academic Hospital in East Jakarta, Indonesia

Kurniyanto et al., Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068

Kurniyanto et al., Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral.., Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068

Feb 2022 Source PDF

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Retrospective 477 hospitalized patients in Indonesia, showing higher mortality with remdesivir in unadjusted results.

[Gérard, Wu, Zhou] show significantly increased risk of acute kidney injury with remdesivir. This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; substantial unadjusted confounding by indication likely.

1. Gérard et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2145, Remdesivir and Acute Renal Failure: A Potential Safety Signal From Disproportionality Analysis of the WHO Safety Database, https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2145.

2. Wu et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.692828, Acute Kidney Injury Associated With Remdesivir: A Comprehensive Pharmacovigilance Analysis of COVID-19 Reports in FAERS, https://www.frontiersin.org/articles/10.3389/fphar.2022.692828/full.

3. Zhou et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.833679, Acute Kidney Injury and Drugs Prescribed for COVID-19 in Diabetes Patients: A Real-World Disproportionality Analysis, https://www.frontiersin.org/articles/10.3389/fphar.2022.833679/full.

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risk of death, 460.0% higher, RR 5.60, p < 0.001, treatment 7 of 45 (15.6%), control 12 of 432 (2.8%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Kurniyanto et al., 28 Feb 2022, retrospective, Indonesia, peer-reviewed, 11 authors.

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Late treatment
is less effective

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