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Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral Academic Hospital in East Jakarta, Indonesia

Kurniyanto et al., Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068
Feb 2022  
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Mortality -460% Improvement Relative Risk Remdesivir  Kurniyanto et al.  LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 477 patients in Indonesia Higher mortality with remdesivir (p=0.00089) c19early.org Kurniyanto et al., J. Clinical Virolog.., Feb 2022 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 477 hospitalized patients in Indonesia, showing higher mortality with remdesivir in unadjusted results.
Gérard, Zhou, Wu show significantly increased risk of acute kidney injury with remdesivir.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; substantial unadjusted confounding by indication likely.
Study covers favipiravir and remdesivir.
risk of death, 460.0% higher, RR 5.60, p < 0.001, treatment 7 of 45 (15.6%), control 12 of 432 (2.8%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kurniyanto et al., 28 Feb 2022, retrospective, Indonesia, peer-reviewed, 11 authors.
This PaperRemdesivirAll
Factors associated with death and ICU referral among COVID-19 patients hospitalized in the secondary referral academic hospital in East Jakarta, Indonesia
Kurniyanto, Yessi Setianegari, Linggom Kurniaty, Danny E J Luhulima, Bambang S R Utomo, Louisa A Langi, Ronny, Evy S Arodes, Marwito Wiyanto, Eva Suarthana, Retno Wahyuningsih
Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Authors contribution K is responsible for the patient during their hospitalization and writing the paper. RW design of the study, analyzed the data and writing the paper. ES analyzed the data, doing statistical analysis and writing the paper, All authors read and approved the final manuscript. Consent for publications Not applicable Competing interest The authors declare that they have no competing interest
References
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Indonesia, Pedoman pencegahan dan pengendalian coronavirus disease (COVID-19) revisi ke-5
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Pouw, Van De Maat, Veerman, Oever, Janssen et al., Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study, PLoS One, doi:10.1371/journal.pone.0248713
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Suhendra, Elyazar, Djaafara, Ekawati, Saraswati et al., Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study, Lancet Reg Health West Pac, doi:10.1016/j.lanwpc.2021.100108
Tamara, Tahapary, Obesity as a predictor for a poor prognosis of COVID-19: A systematic review, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.05.020
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Zhang, Wang, Jia, Li, Hu et al., Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China, Clin Microbiol Infect, doi:10.1016/j.cmi.2020.04.012
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Late treatment
is less effective
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