Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral Academic Hospital in East Jakarta, Indonesia

Kurniyanto et al., Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068

Feb 2022

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Retrospective 477 hospitalized patients in Indonesia, showing lower mortality with favipiravir in unadjusted results, not reaching statistical significance.

Potential risks of favipiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-5.

This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.

Important missing comments or errors? Let us know.

Study covers favipiravir and remdesivir.

risk of death, 48.0% lower, RR 0.52, p = 0.21, treatment 10 of 325 (3.1%), control 9 of 152 (5.9%), NNT 35.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. Zhirnov et al., Favipiravir: the hidden threat of mutagenic action, Journal of microbiology, epidemiology and immunobiology, doi:10.36233/0372-9311-114.elpub.ru, doi.org.

2. Waters et al., Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir, Environmental and Molecular Mutagenesis, doi:10.1002/em.22471.wiley.com, doi.org.

3. Hadj Hassine et al., Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity, Viruses, doi:10.3390/v14040841.mdpi.com, doi.org.

4. Shum, C., An investigational study into the drug-associated mutational signature in SARS-CoV-2 viruses, The University of Hong Kong, PhD Thesis, hub.hku.hk/handle/10722/344396.hku.hk.

5. Shiraki et al., Convenient screening of the reproductive toxicity of favipiravir and antiviral drugs in Caenorhabditis elegans, Heliyon, doi:10.1016/j.heliyon.2024.e35331.sciencedirect.com, doi.org.

Kurniyanto et al., 28 Feb 2022, retrospective, Indonesia, peer-reviewed, 11 authors.

This Paper Favipiravir All

Factors associated with death and ICU referral among COVID-19 patients hospitalized in the secondary referral academic hospital in East Jakarta, Indonesia

Kurniyanto, Yessi Setianegari, Linggom Kurniaty, Danny E J Luhulima, Bambang S R Utomo, Louisa A Langi, Ronny, Evy S Arodes, Marwito Wiyanto, Eva Suarthana, Retno Wahyuningsih

Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Authors contribution K is responsible for the patient during their hospitalization and writing the paper. RW design of the study, analyzed the data and writing the paper. ES analyzed the data, doing statistical analysis and writing the paper, All authors read and approved the final manuscript. Consent for publications Not applicable Competing interest The authors declare that they have no competing interest

References

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Chen, Liang, Jiang, Guan, Zhan et al., Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China, Chest, doi:10.1016/j.chest.2020.04.010

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Guan, Ni, Yu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med, doi:10.1056/NEJMoa2002032

Indonesia, Pedoman pencegahan dan pengendalian coronavirus disease (COVID-19) revisi ke-5

Jia, Yin, Lu, Chen, Liu et al., Two things about COVID-19 might need attention, Preprints, doi:10.20944/preprints202002.0315.v1

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Peron, Nakaya, Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2

Pouw, Van De Maat, Veerman, Oever, Janssen et al., Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study, PLoS One, doi:10.1371/journal.pone.0248713

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Suhendra, Elyazar, Djaafara, Ekawati, Saraswati et al., Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study, Lancet Reg Health West Pac, doi:10.1016/j.lanwpc.2021.100108

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Zhang, Wang, Jia, Li, Hu et al., Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China, Clin Microbiol Infect, doi:10.1016/j.cmi.2020.04.012

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Late treatment
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