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c19early.org COVID-19 treatment researchAzvudineAzvudine (more..)
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Association of Azvudine with severe outcomes among hospitalized patients with COVID-19 during an omicron-dominance period in Wuhan, China: a single-center, retrospective, matched cohort study

Guo et al., BMC Infectious Diseases, doi:10.1186/s12879-025-11625-8, ChiCTR2300072963, Oct 2025
https://c19early.org/guo4.html
Mortality 56% improvement lower risk ← → higher risk ICU/mechanical ventil.. 62% Viral clearance 34% Azvudine for COVID-19  Guo et al.  EARLY TREATMENT Is early treatment with azvudine beneficial for COVID-19? PSM retrospective 1,406 patients in China (December 2022 - May 2023) Lower mortality (p=0.0047) and progression (p<0.0001) c19early.org Guo et al., BMC Infectious Diseases, Oct 2025 0 0.5 1 1.5 2+ RR
Azvudine for COVID-19
47th treatment shown to reduce risk in January 2023, now with p = 0.000000017 from 39 studies.
No treatment is 100% effective. Protocols combine treatments.
6,200+ studies for 180 treatments. c19early.org
Retrospective 1,406 hospitalized COVID-19 patients (703 matched pairs) in China showing significantly lower mortality and mechanical ventilation/ICU admission, and faster viral clearance with azvudine.
Liver injury. Studies show significantly increased risk of liver injury1,2.
Standard of Care (SOC) for COVID-19 in the study country, China, is poor with low average efficacy for approved treatments3.
risk of death, 56.0% lower, HR 0.44, p = 0.005, treatment 703, control 703, propensity score matching.
ICU/mechanical ventilation, 62.0% lower, HR 0.38, p < 0.001, treatment 703, control 703, propensity score matching.
risk of no viral clearance, 34.2% lower, HR 0.66, p < 0.001, treatment 703, control 703, inverted to make HR<1 favor treatment, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Guo et al., 14 Oct 2025, retrospective, China, peer-reviewed, mean age 65.4, 12 authors, study period 1 December, 2022 - 31 May, 2023, trial ChiCTR2300072963. Contact: sunfeng@bjmu.edu.cn, zhaoshi.cmsa@gmail.com, chenghong@znhospital.cn.
Association of Azvudine with severe outcomes among hospitalized patients with COVID-19 during an omicron-dominance period in Wuhan, China: a single-center, retrospective, matched cohort study
Zihao Guo, Wenjing Li, Kailu Wang, Yun Lu, Suyu Gao, Xinping Wang, Yanji Zhao, Ziyu Zhai, Boqiang Chen, Feng Sun, Shi Zhao, Hong Cheng
BMC Infectious Diseases, doi:10.1186/s12879-025-11625-8
Background Constantly emerging SARS-CoV-2 genetic variants with potent immune escape kept the COVID-19 pandemic ongoing. Apart from vaccination, effective antiviral drug is necessary to achieve clinical improvement, especially for hospitalized patients. To date, there was limited data on the clinical effectiveness of Azvudine. This study aimed to provide a comprehensive assessment of the effectiveness of Azvudine among hospitalized COVID-19 patients in a real-world healthcare setting. Method In this single-center, retrospective cohort study, hospitalized patients with laboratory-confirmed SARS-CoV-2 infection from Dec 1, 2022 to May 31, 2023 were recruited in a tertiary hospital in Wuhan, China. Azvudine recipients and controls were propensity-score matched with a ratio of 1:1, based on age, sex, baseline Charlson comorbidity index, time from symptom onset to treatment exposure, initiation of concomitant treatment at admission, and abnormality of chest computed tomography image. The primary outcomes included a composite measure of severe outcomes (ICU admission and invasive mechanical ventilation), and all-cause death, and the secondary outcome was the time to negative nucleic acid conversion. Subgroup analyses were performed according to the matching covariates. The incidence rate was computed, and the hazard ratio (HR) was estimated by using the Cox proportional hazards regression model for each outcome.
Declarations Ethics approval and consent to participate This study was approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University (No.: 2023013 K). The need for obtaining informed consent to participate was waived by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University. This study adhered to the Declaration of Helsinki. Consent for publication Not applicable. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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