The efficacy of Zafirlukast as a SARS-CoV-2 helicase inhibitor in adult patients with moderate COVID-19 Pneumonia (pilot randomized clinical trial)

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"year": "2018" }, { "key": "10.1016/j.jiph.2022.11.016_bib8", "unstructured": "World Health Organization. WHO R&D Blueprint Novel Coronavirus COVID-19 Therapeutic Trial Synopsis 2020a, available at https://www.who.int/publications/i/item/covid-19-therapeutic-trial-synopsis." }, { "DOI": "10.1002/cbic.200800491", "article-title": "Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase", "author": "Shum", "doi-asserted-by": "crossref", "first-page": "3037", "journal-title": "Chembiochem", "key": "10.1016/j.jiph.2022.11.016_bib9", "volume": "9", "year": "2008" }, { "DOI": "10.1016/j.bbrc.2007.12.020", "article-title": "Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase", "author": "Jang", "doi-asserted-by": "crossref", "first-page": "738", "journal-title": "Biochem Biophys Res Commun", "key": "10.1016/j.jiph.2022.11.016_bib10", "volume": "366", "year": "2008" }, { "DOI": "10.1056/NEJMoa2019014", "article-title": "Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19", "author": "Cavalcanti", "doi-asserted-by": "crossref", "first-page": "2041", "journal-title": "N Engl J Med", "key": "10.1016/j.jiph.2022.11.016_bib11", "volume": "383", "year": "2020" }, { "key": "10.1016/j.jiph.2022.11.016_bib12", "unstructured": "Horby P., Mafham M., Linsell L., et al.; RECOVERY Collaborative Group. Effect of hydroxychloroquine in hospitalized patients with COVID-19. N Engl J Med. 2020." }, { "DOI": "10.1001/jama.2020.22240", "article-title": "Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial", "author": "Self", "doi-asserted-by": "crossref", "first-page": "2165", "issue": "21", "journal-title": "JAMA", "key": "10.1016/j.jiph.2022.11.016_bib13", "volume": "324", "year": "2020" }, { "DOI": "10.1056/NEJMc2001737", "doi-asserted-by": "crossref", "key": "10.1016/j.jiph.2022.11.016_bib14", "unstructured": "Zou L., Ruan F., Huang M., Liang L. , Huang H. , Hong Z. , et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. DOI: 10.1056/NEJMc2001737." }, { "DOI": "10.1183/13993003.01190-2020", "article-title": "Risk factors for viral RNA shedding in COVID-19 patients", "author": "Fu", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Eur Respir J", "key": "10.1016/j.jiph.2022.11.016_bib15", "volume": "56", "year": "2020" }, { "DOI": "10.1038/s41591-020-0869-5", "article-title": "Temporal dynamics in viral shedding and transmissibility of COVID-19", "author": "He", "doi-asserted-by": "crossref", "first-page": "672", "journal-title": "Nat Med", "key": "10.1016/j.jiph.2022.11.016_bib16", "volume": "26", "year": "2020" }, { "DOI": "10.1016/j.healun.2020.03.012", "article-title": "COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal", "author": "Siddiqi", "doi-asserted-by": "crossref", "first-page": "405", "journal-title": "J Heart Lung Transpl", "key": "10.1016/j.jiph.2022.11.016_bib17", "volume": "39", "year": "2020" }, { "DOI": "10.1016/j.bbrc.2004.04.083", "article-title": "HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus", "author": "Yamamoto", "doi-asserted-by": "crossref", "journal-title": "Biochem Biophys Res Commun", "key": "10.1016/j.jiph.2022.11.016_bib18", "year": "2004" }, { "article-title": "Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study", "author": "Chan", "journal-title": "Hong Kong Med J", "key": "10.1016/j.jiph.2022.11.016_bib19", "year": "2003" }, { "DOI": "10.1186/s13063-017-2427-0", "article-title": "Treatment of middle east respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial", "author": "Arabi", "doi-asserted-by": "crossref", "journal-title": "Trials", "key": "10.1016/j.jiph.2022.11.016_bib20", "volume": "19", "year": "2018" }, { "DOI": "10.1016/S0140-6736(20)31042-4", "article-title": "Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial", "author": "Hung", "doi-asserted-by": "crossref", "first-page": "1695", "journal-title": "Lancet", "key": "10.1016/j.jiph.2022.11.016_bib21", "volume": "395", "year": "2020" } ], "reference-count": 21, "references-count": 21, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1876034122003094" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "The efficacy of Zafirlukast as a SARS-CoV-2 helicase inhibitor in adult patients with moderate COVID-19 Pneumonia (pilot randomized clinical trial)", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "volume": "15" }